11/10/2025
It’s true! Your gut health has a direct impact on your hormonal health through something called the estrobolome.
Certain microbes in your gut play a huge role in your body’s metabolism of estrogen. These microorganisms are collectively referred to as the estrobolome. Many of these microbes produced an enzyme in your gut called beta-glucuronidase that is key to regulating estrogen levels in your body.
Let’s back up and run through the steps of estrogen metabolism real quick: estrogen is produced by the ovaries, circulates in your blood stream, and then needs to be detoxified by the liver and excreted. The main pathway for excreting estrogen is through the gut, meaning you have to 💩 it out. By the time that estrogen makes it to the gut, it has been altered by the liver to become inactive and bound to something called glucuronic acid.
Alright, now back to the role to the gut microbiome here! Beta-glucuronidase breaks this bond between estrogen and glucuronic acid, which then makes it possible for your body to reabsorb estrogen before it is fully excreted.
If you have lots of bacteria in your gut that make beta-glucuronidase, you will reabsorb more estrogen, allowing it to recirculate, and causing high estrogen symptoms like breast tenderness, menstrual cramps, heavy periods, PMS/PMDD, and even uterine fibroids. Additionally, if you aren’t have a bowel movement daily, this gives your body more time to reabsorb this estrogen from your gut as well.
Like or leave a comment if you want some tips on how to improve your hormones through your gut health!