972 Dean

02/02/2026

How CBG added with CBD Boosts Anti-Seizure Effects.

Antiseizure Effects of CBD in Combination With CBG

✔️ Study Purpose

• Examine whether combining cannabidiol (CBD) with cannabigerol (CBG) improves seizure control

• Use the maximal electroshock seizure model in mice, a standard preclinical epilepsy model

• Address unmet need as roughly one third of epilepsy patients remain drug resistant

✔️ Methods

• CBD alone, CBG alone, and CBD plus CBG were administered prior to seizure induction

• Dose effectiveness and dose related toxicity were quantified

• ED₅₀ and TD₅₀ values were calculated to assess therapeutic window

✔️ Key Findings

• CBG alone demonstrated measurable antiseizure activity

• Combining CBD with CBG reduced the effective CBD dose by over 50 percent

• The combination lowered the CBD toxicity threshold by approximately 40 percent

• Effects were additive rather than unpredictable or synergistically toxic

✔️ Clinical Significance

• CBG may act as both an independent antiseizure compound and a potentiator of CBD

• Lower required CBD doses may reduce side effect burden

• Supports exploration of cannabinoid combinations for drug resistant epilepsy

✔️ Conclusion

• This study provides the first detailed dose–response and dose–toxicity characterization of CBG and CBD combinations in a seizure model.

• Non-psychoactive cannabinoids like CBG may have meaningful roles in enhancing existing antiseizure compounds such as CBD.

• Future research should explore mechanisms, optimal ratios, and translation to clinical contexts.

January 2026
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Truong M Nguyen
Truong M Nguyen

01/31/2026

Meanwhile, Roger Adams turned out to have a whimsical side. During a lecture to the National Academy of Sciences, detailing his work, he remarked casually that ‘ma*****na,’ when smoked, had “pleasant effects.” This remark caused a major uproar. Anslinger snarled at Adams, and the Office of Naval Intelligence (ONI) wanted him labeled a security risk. Members of his team argued that they could not do without him. They called upon the FBI’s J. Edgar Hoover to intervene. Hoover lied. He told ONI that Adams was a very common name, and they must have gotten the wrong guy. Adams was placed, after this event, on a list of “people to be watched.”



Unrepentant, he became an equal opportunity supplier. If you read the La Guardia Report, you will come across this statement. “We are indebted to Dr. Roger Adams at the University of Illinois, and to Dr. H. J. Wollner, consulting chemist of the US Treasury, who supplied some of the active principles of ma*****na which were used in the study.”4 Anslinger was enraged, called the study unscientific, roared at the chemists, and the rest is history. It is hard to fathom the selective bias that has coloured so many historical accounts. But the next time they tell you that THC was discovered in 1964, don’t believe it. It just ain’t so.

01/30/2026

01/27/2026

01/27/2026

Long-Term Study Shows Cannabis Improves Sleep, Mood, and Pain in Insomnia Patients
Cannabis-based medical products have been shown to improve sleep quality, mood, and pain management in insomnia patients, according to a long-term study.
Published in PLOS Mental Health, the research followed 124 participants aged 18 and older over an 18-month period. Results revealed that patients experienced steady benefits throughout the study.
The improvements were linked to the effects of tetrahydrocannabinol (THC), one of cannabis's key compounds. Participants reported better sleep quality, reduced pain levels, and improved overall mood across the entire study duration.
What makes this research significant is the long-term nature of the findings. Many sleep aids lose effectiveness over time or come with worsening side effects. This study showed sustained benefits without diminishing returns over 18 months.
These findings suggest cannabis may offer a safe and effective option for managing chronic insomnia, particularly for patients who haven't found relief through traditional medications or who want to avoid the dependency risks associated with standard sleep aids.
However, it's important to note that this research examined medical cannabis products under controlled conditions. The quality, dosing, and formulation matter significantly for safety and effectiveness.
If you struggle with chronic insomnia, this research adds to the growing evidence that medical cannabis might be worth discussing with your healthcare provider as part of a comprehensive treatment plan.
Reference: PLOS Mental Health - "Long-term effects of cannabis-based products on insomnia patients"

01/27/2026

The 4 Horsemen…

01/26/2026

Cannabis Compounds Kill Deadly Fungal Infections Better Than Current Drugs—Scientists Are Shocked
Scientists say it may be the key to beating deadly fungal infections.
Two compounds found in cannabis—cannabidiol (CBD) and cannabidivarin (CBDV)—have demonstrated potent antifungal properties in a breakthrough study from Macquarie University.
Researchers discovered that these non-psychoactive and mildly psychoactive compounds effectively killed Cryptococcus neoformans, a lethal fungus responsible for life-threatening meningitis. In lab tests, CBD and CBDV acted even faster than standard antifungal medications, disrupting fungal membranes and metabolic pathways.
The compounds also eliminated common skin fungi, such as those that cause athlete's foot and jock itch.
To explore real-world potential, scientists used moth larvae with immune systems similar to mammals. When infected larvae were treated topically with CBD, their survival rate nearly matched that of uninfected controls—outperforming current gold-standard antifungal treatments.
While more research is needed before human use, especially for internal infections, the study paves the way for CBD-based topicals to combat skin fungal infections.
With drug resistance on the rise and fungal infections becoming increasingly difficult to treat, cannabis compounds could offer a timely and natural new defense. Current antifungal drugs are losing effectiveness as fungi evolve resistance, making the search for alternative treatments urgent.
This discovery reveals yet another medical application hidden inside the cannabis plant—one that could save lives as drug-resistant infections spread globally.
Reference: Macquarie University study on cannabis compounds and antifungal properties - "CBD and CBDV antifungal efficacy"

01/26/2026

If you go back to the beginning .
This is what it looked like.
Thanks Two & Wu !!
Where would we be without you?