11/25/2025
Ketone Supplementation & Heart Health 🫀✨
Can ketones help support heart function?
Emerging clinical research says yes.
A new systematic review & meta-analysis titled:
“Effect of ketone supplementation, a low-carbohydrate diet and a ketogenic diet on heart failure measures and outcomes” has brought important insights into how ketone metabolism affects cardiac health.
🔬 What the Research Shows
Patients with heart failure often have impaired ability to use glucose effectively for fuel.
But the heart LOVES ketones—especially β-hydroxybutyrate (BHB)—because they:
✨ Burn cleaner
✨ Produce more energy per molecule
✨ Reduce oxidative stress
✨ Support mitochondrial efficiency
The meta-analysis found that:
➡️ Ketone supplementation improved cardiac output and ejection fraction in several studies
➡️ Patients receiving exogenous ketones showed improved exercise capacity and oxygen utilization
➡️ Ketogenic or low-carb diets improved metabolic flexibility, which may reduce the burden on a failing heart
➡️ Ketones may reduce inflammatory signaling, a major driver of heart failure progression
🧪 Why This Matters Clinically
For individuals with early cardiometabolic dysfunction, insulin resistance, or metabolic inflexibility, ketone-based therapies may offer a complementary support strategy alongside standard care.
Ketone esters or salts may:
✔ Improve energy availability in heart tissue
✔ Support exercise tolerance
✔ Reduce symptoms of fatigue and dyspnea
✔ Stabilize blood sugar and insulin levels
Nutritional ketosis may:
✔ Improve metabolic efficiency
✔ Reduce inflammation
✔ Support mitochondrial repair
✔ Decrease cardiac workload
⚠️ Important Notes
This research is promising—but ketone supplementation is not a replacement for cardiology care.
It should be used under practitioner guidance, especially for:
• Patients with arrhythmia
• Diabetes on insulin
• Individuals taking SGLT2 inhibitors or diuretics
💡 Takeaway
Ketones aren’t just a fuel source—they’re a therapeutic metabolic signal.
This new evidence suggests that ketone supplementation and ketogenic therapies may support the failing heart, improve energy production, and enhance quality of life.
If you’d like more breakdowns of emerging metabolic research, comment KETONES below. ⚡️💙