Schneider Lab

02/25/2025

Dr. Schneider presents our group's work, which was recently incorporated into the cancer guidelines (nccn.org), at the NCCN congress at Northwestern University in Chicago.

09/17/2024

https://news.iu.edu/live/news/37840-iu-research-targets-debilitating-side-effects-for

IU researchers are leading the way to improving quality of life and curative chemotherapy doses for Black patients with breast cancer — with help from t...

08/26/2024

"The results of this study are concordant with other in vitro drug toxicity studies highlighting similar significant experimental parameters affecting dose response. However, our study specifically examines these parameters in the context of an iPSC-derived sensory neuron model, identifying optimal conditions for the evaluation of taxane-induced neurotoxicity." (Cantor et al., 2024)

Read more here: https://rdcu.be/dRbKn

08/22/2024

Check out our latest work, just published with Springer Nature in Scientific Reports, concerning the optimization of our neuron model for the assessment of taxane-induced neurotoxicity. You can access the article for free here: https://rdcu.be/dRbKn

06/13/2024

https://ascopubs.org/do/eaz171-predictors-tipn-black-women-breast-cancer

Dr. Shannon Westin and her guest, Dr. Bryan Schneider discuss the article “ECOG-ACRIN EAZ171: Prospective Validation Trial of Germline Predictors of Taxane-induced Peripheral Neuropathy in Black Women with Early Stage Breast Cancer” recently published in the JCO and presented at the 2024 ASCO An...

06/13/2024

https://ascopost.com/news/june-2024/study-including-only-black-patients-with-breast-cancer-compares-rates-of-taxane-induced-peripheral-neuropathy/

New findings suggest that docetaxel may be considered the preferred treatment over paclitaxel for Black patients with early-stage breast cancer. While the EAZ171 trial focused specifically on Black pe...

06/13/2024

https://www.komen.org/blog/personalized-chemo/

Komen Scholar Bryan Schneider, M.D., trial lead for the EAZ171 clinical trial, is seeking to overcome these disparities in outcomes for Black women with breast cancer by personalizing chemotherapy.

06/13/2024

https://medicine.iu.edu/news/2024/06/eaz171-breast-cancer-study

New study by IU cancer center researchers could improve quality of life and curative chemotherapy doses for Black patients who face disparate outcomes in breast cancer

06/13/2024

Exciting news from the world of science!

Tarah Ballinger, MD, a dedicated researcher at IU School of Medicine, is making strides in breast cancer research. Notably, Dr. Ballinger has previously utilized KTB samples to delve into the intricacies of breast cancer.

Her recent work on the EAZ171 clinical trial is a testament to her commitment to advancing the field. Click the link to read about how Chemotherapy type can be personalized to decrease harmful side effects for Black patients with breast cancer: https://medicine.iu.edu/news/2024/06/eaz171-breast-cancer-study

Stay tuned for more updates as we continue to support and celebrate the incredible contributions of researchers like Dr. Ballinger in the fight against breast cancer.

06/13/2024

Our latest study comparing the rates of chemotherapy-induced peripheral neuropathy in Black women with breast cancer was recently presented at the 2024 ASCO Annual Meeting and simultaneously published in the Journal of Clinical Oncoloy. This work highlights the importance of personalized therapy and focuses on an underserved and underrepresented minority population.

Check out this article about the study:

https://medicine.iu.edu/news/2024/06/eaz171-breast-cancer-study

You can also find the publication here:

https://ascopubs.org/doi/10.1200/JCO.24.00526

PURPOSE Black women experience higher rates of taxane-induced peripheral neuropathy (TIPN) compared with White women when receiving adjuvant once weekly paclitaxel for early-stage breast cancer, leading to more dose reductions and higher recurrence rates. EAZ171 aimed to prospectively validate germl...

09/27/2023

In September of 2022, the Schneider Lab published an article in Nature Scientific Reports titled "Passage number affects differentiation of sensory neurons from human induced pluripotent stem cells." By March of 2023, the article reached the Top 100 Neuroscience papers in Scientific Reports, with almost 1,000 downloads in less than six months!

As of July 2023, this article has continued to draw attention, now with over 2,000 total downloads! This type of work will help to support the foundations of research and lead to the generation of better laboratory models for the study of breast cancer and many other diseases.

The article is open access and can be found here:
https://www.nature.com/articles/s41598-022-19018-6?utm_medium=email&utm_source=hybris-campaign&utm_content=upload_list&utm_term=null&utm_campaign=CONR_NATOA_CON1_GL_PHSS_00310_AAA-SREP&sap-outbound-id=B6D358887821F4D61B42CA68C27F651BB4544E69&utm_source=complex&utm_medium=email&utm_campaign=000_PAND05_0000030942_CONR_NATOA_CON1_GL_PHSS_00310_AAA-23Q3&utm_content=EN_57354_20230912&mkt-key=42010A0553051EDBB9CD04A39E29108A