07/11/2022
Question Monday from Dr. Jensen Online Question Bank!
Which of the following is typically associated with photosensitivity:
A. Garlic
B. Ginseng
C. Gingko
D. St. Johns wort
E. none of the above
Answer: See Below!
Nutraceuticals: photosensitivity
1. Remember, when it comes to neutraceuticals, “The G’s cause C’s,” namely coagulopathies.
2. Let’s look at the players:
Garlic
a. Garlic has been used for centuries for a variety of ailments. Recent studies have centered upon purported vasodilator and hypocholesterolemic activity. A British study suggests garlic may lower total cholesterol by 12%, while other studies are nonconfirmatory. Less solid evidence exists for antihypertensive effects. An important side effect appears to be decreased platelet aggregation. Garlic may augment the effects of warfarin, heparin, nonsteroidal anti-inflammatory agents, and aspirin. One reported case links garlic to spontaneous spinal/epidural hematoma.
Ginseng
a. The active compound in ginseng is ginsenoside. It has been used for anti-aging, energy boosting, and as an aphrodisiac. Ginseng has also been shown to have a hypoglycemic effect and should be avoided in in patients on insulin or oral hypoglycemics. Like garlic, ginger, and ginko ginseng should be avoided in patients on coumadin, heparin, NSAIDs, and aspirin or those requiring neuraxial blockade. Ginseng also causes hypertension. Ginseng should not be used with MAOIs as manic episodes have resulted from this combination.
Ginko biloba
a. Ginko has been used for medicinal purposes since 3000 B.C. It is one of the best-selling herbs in the United States, with annual revenue exceeding $250 million. It is used for a variety of purposes including intermittent claudication, tinnitus, memory loss, and impotence. Ginko is considered relatively safe but has been associated with bleeding abnormalities, including spontaneous hyphema (bleeding from the iris into the anterior chamber), subarachnoid hemmorhage, and spontaneous subdural hematoma. Like garlic and ginger, ginko should be avoided in patients on coumadin, heparin, NSAIDs, and aspirin or those requiring neuraxial blockade. Ginko should also probably be avoided with the concomitant use of anticonvulsives and TCAs, as it seems to decrease the effectiveness of these agents by an unknown mechanism.
St. John’s Wort
a. St. John’s Wort is most commonly used for anxiety, depression, and sleep disorders. It is one of the most popular drugs in Germany, with several million regular users. Its mechanism of action is likely to be GABA or serotonin receptor inhibition. Photosensitivity is the most common side effect and photosensitive drugs such as tetracycline and piroxicam should not but used concomitantly.
Answer: D. (St. Johns wort)
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