enVVeno Medical

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Irvine, CA
enVVeno Medical

ABOUT THE TRIAL: What is the SAVVE Study? What is the VenoValve Procedure? How long is the SAVVE study? It is important to follow all post-procedure instructions.

We are a clinical-stage medical device company focused on the advancement of innovative bioprosthetic (tissue-based) solutions to improve the standard of care for the treatment of venous disease. Chronic Venous Insufficiency (CVI) occurs when the valves inside the veins of your leg do not function properly, causing blood to flow backward and pool in the lower leg, leading to elevated venous pressure inside the leg veins. The purpose of the SAVVE study is to determine whether the VenoValve® is a safe and effective treatment for patients with severe, deep venous CVI. The VenoValve is surgically implanted into a vein via a 5 to 6-inch incision in the upper thigh. The procedure should take less than an hour and the patient will receive general or regional anesthesia. After the VenoValve procedure, the patient will stay in the hospital for one night for patient comfort. The patient will be asked to see their doctor 7 days, 30 days, 90 days, 180 days, and 365 days after the VenoValve procedure. The VenoValve is designed to be a permanent implant and the patient should continue to see their doctor once a year for at least the next 4 years. FIRST-IN-HUMAN STUDY: Am I the first patient to receive a VenoValve? Eleven patients have already received the VenoValve as part of a small clinical trial. Safety incidences were minor, the disease severity (VCSS scores) improved an average of 56%, and pain (VAS scores) improved an average of 76%, compared to pre-VenoValve levels. The patients also experienced a significant improvement in their quality of life and were able to resume pre-CVI activities. The VenoValve stopped working after one patient stopped taking their prescribed medication.

01/23/2026

We are working to develop medical solutions that may help restore mobility, comfort and confidence for people living with venous disease.

Learn more about our team here: https://bit.ly/3xSC1bS

01/16/2026

: Chronic Venous Disease is the most prevalent chronic disease in the U.S., impacting an estimated 175 million adults. CVD includes a range of venous conditions, with Chronic Venous Insufficiency (CVI) as a major subset caused by increased venous pressure from malfunctioning leg vein valves.

01/15/2026

enVVeno Medical Announces Reverse Stock Split

https://bit.ly/3Zj22iE

01/12/2026

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01/09/2026

We recently hosted a LIVE CEO Connect with Rob Berman, CEO of enVVeno Medical, sharing a corporate overview and key updates on the Company’s mission in venous disease.

If you missed it, here’s your chance to catch up: https://bit.ly/43TH391

Welcome! You are invited to join a webinar: Virtual Investor Live CEO Connect Segment Featuring enVVeno Medical (NASDAQ:NVNO). After registering, you will receive a confirmation email about joining the webinar.

01/06/2026

We remain committed to setting new standards for venous care.

12/22/2025

As the year winds down, we’re already gearing up for 2026!

We’re eager to see what the new year holds and look forward to sharing what we have in store. Stay tuned!

We wish everyone a very safe and and a .

12/09/2025

Our legs are made up of three main types of veins that work together to keep the blood flowing from the legs back to the heart and lungs.

Learn more about these veins.

11/26/2025

This Thanksgiving, we're grateful for the enVVeno team that works tirelessly every day to improve the lives of those living with severe deep .

We're also thankful for the community for their support of our work to bring them much needed relief and treatment options for their disease.

Happy Thanksgiving!

11/05/2025

is a frustrating disease to live with, as there is a distinct lack of treatments available, and can turn even the simplest tasks into mammoth undertakings.

See what Dr. David Dexter has to say about the toll takes on one’s quality of life.

10/21/2025

There are many symptoms of severe deep venous . It’s important to talk to your doctor about everything that is bothering you. Clear communication is the best path to a correct diagnosis.

For millions living with severe deep , managing symptoms isn’t enough.

10/14/2025

What is ?
How many people suffer from it?
What are the symptoms?
What are the treatment options? (Spoiler: there aren’t any)

See the answers from Dr. Matthew Smeds on these and other challenges below.

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Irvine, CA

Website

https://envveno.com/

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