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We provide reliable and updated medical information to healthcare providers, insurance companies, and educational institutions and assist healthcare providers in making appropriate clinical decisions, meeting medical necessity, and maintaining compliance

Anti-DNase B antibody is an immunoglobulin produced by the immune system in response to deoxyribonuclease B (DNase B), a...
01/13/2026

Anti-DNase B antibody is an immunoglobulin produced by the immune system in response to deoxyribonuclease B (DNase B), an enzyme secreted by Streptococcus pyogenes (group A streptococcus). Measurement of anti-DNase B levels is used to detect recent streptococcal infections, particularly when throat cultures are negative or infection occurred weeks earlier. Unlike antistreptolysin O (A*O), anti-DNase B antibodies are more consistently elevated following skin infections such as impetigo. Elevated titers support the diagnosis of post-streptococcal complications, including acute rheumatic fever and post-streptococcal glomerulonephritis. Anti-DNase B testing is often performed alongside A*O testing to improve diagnostic sensitivity. Results should be interpreted in the context of clinical findings and rising antibody titers over time.

Liquid-based cytology (LBC) is a modern cytological technique widely used for cervical cancer screening and other cytolo...
01/10/2026

Liquid-based cytology (LBC) is a modern cytological technique widely used for cervical cancer screening and other cytology specimens. In this method, cells collected from the patient are suspended in a liquid preservative rather than being directly smeared onto a glass slide. This approach improves sample quality by reducing obscuring factors such as blood, mucus, and inflammatory debris, resulting in a cleaner and more uniform cell presentation. LBC enhances diagnostic accuracy and reproducibility compared to conventional cytology. An additional advantage is that residual cellular material in the preservative can be used for ancillary testing, including human papillomavirus (HPV) testing and molecular analyses. Overall, liquid-based cytology has improved screening efficiency and contributed significantly to early detection of precancerous and malignant lesions.

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) f...
01/08/2026

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) for any given disease by meeting the medical necessity and, thereby improve reimbursement rates. Every order submitted using the Company's CPOE automatically will include the correct ICD10 and CPT codes and will be checked for Medicare LCDs and NCDs to ensure medical necessity is met.

KRAS gene mutations play a central role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), t...
01/08/2026

KRAS gene mutations play a central role in the development and progression of pancreatic ductal adenocarcinoma (PDAC), the most common form of pancreatic cancer. Activating KRAS mutations are present in over 90% of PDAC cases, most frequently involving codons 12, 13, or 61. These mutations lead to constitutive activation of KRAS signaling, promoting uncontrolled cell proliferation, survival, metabolic reprogramming, and resistance to apoptosis. Aberrant KRAS signaling also influences the tumor microenvironment by driving inflammation, fibrosis, and immune evasion. KRAS mutations are considered early events in pancreatic tumorigenesis and persist throughout disease progression. Although historically difficult to target therapeutically, recent advances have led to the development of mutation-specific KRAS inhibitors, offering emerging opportunities for precision treatment in selected patients. Learn more about the testing with Medical Database.

MECP2 gene mutation analysis is a molecular diagnostic test used to detect pathogenic variants in the MECP2 gene, which ...
01/06/2026

MECP2 gene mutation analysis is a molecular diagnostic test used to detect pathogenic variants in the MECP2 gene, which is located on Xq28 and encodes methyl-CpG–binding protein 2, a key regulator of gene expression and chromatin structure in the central nervous system. Pathogenic variants in MECP2 are most commonly associated with Rett syndrome, an X-linked neurodevelopmental disorder affecting primarily females, as well as atypical Rett phenotypes and severe neonatal encephalopathy in males. The analysis typically involves sequencing of coding exons and exon–intron boundaries, with deletion/duplication testing to identify larger genomic rearrangements. Results support diagnosis, prognosis, genetic counseling, and recurrence risk assessment in affected families.

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthr...
01/03/2026

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthrough that enhances the precision and power of our platform.

We’re proud to be among the first to achieve this milestone in linking resistance data to specific pathogens, driving smarter and faster clinical insights.

A new chapter has started. We wish you an incredibly joyous and successful new year.Happy New Year 2026 !!! ⭐️🎊Thank you...
01/01/2026

A new chapter has started. We wish you an incredibly joyous and successful new year.
Happy New Year 2026 !!! ⭐️🎊
Thank you for trusting our services. Click here to explore more:
https://www.medicaldatabase.com/

Biotinidase deficiency is a rare inherited metabolic disorder caused by mutations in the BTD gene, leading to insufficie...
12/29/2025

Biotinidase deficiency is a rare inherited metabolic disorder caused by mutations in the BTD gene, leading to insufficient activity of the enzyme biotinidase. This enzyme is essential for recycling biotin, a vitamin critical for carboxylase enzyme function involved in fatty acid synthesis, amino acid catabolism, and gluconeogenesis. Without adequate biotinidase activity, affected individuals develop neurological, dermatological, and immunological symptoms, including seizures, hypotonia, developmental delay, eczema, hair loss, and recurrent infections. The condition is autosomal recessive, meaning both copies of the gene must be mutated for symptoms to appear. Early newborn screening allows prompt treatment with oral biotin supplementation, which can prevent severe complications and improve long-term outcomes. Untreated, the disorder may lead to irreversible neurological damage.

As we approach the end of another remarkable year, we want to take a moment to thank each of you for your dedication, an...
12/25/2025

As we approach the end of another remarkable year, we want to take a moment to thank each of you for your dedication, and hard work to the profession. May this Christmas be filled with love, joy, and laughter. Merry Christmas!

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and anti...
12/23/2025

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and antibiotic resistance, generating real-time, guideline-oriented pharmacotherapeutic recommendations according to detected microbial load and antimicrobial resistance genes. Learn more about our products:
www.medicaldatabase.com

PTEN gene mutation analysis evaluates alterations in the PTEN tumor suppressor gene, which regulates cell growth, surviv...
12/18/2025

PTEN gene mutation analysis evaluates alterations in the PTEN tumor suppressor gene, which regulates cell growth, survival, and the PI3K/AKT/mTOR signaling pathway. Loss-of-function PTEN mutations lead to uncontrolled cellular proliferation and are implicated in multiple malignancies, including breast, endometrial, prostate, and glioblastoma, as well as hereditary cancer syndromes such as PTEN hamartoma tumor syndrome (Cowden syndrome). Molecular testing is typically performed using next-generation sequencing on tumor tissue or germline DNA, and may be complemented by copy number analysis or immunohistochemistry for PTEN protein loss. Identifying PTEN alterations has diagnostic, prognostic, and therapeutic relevance, particularly in guiding targeted therapy selection and assessing cancer risk in affected individuals.

Anti-Müllerian hormone (AMH) is a glycoprotein hormone belonging to the transforming growth factor-β family. In females,...
12/16/2025

Anti-Müllerian hormone (AMH) is a glycoprotein hormone belonging to the transforming growth factor-β family. In females, it is produced by granulosa cells of preantral and small antral ovarian follicles and reflects the size of the remaining follicular pool. AMH is widely used as a biomarker of ovarian reserve, helping to assess reproductive potential, predict response to assisted reproductive techniques, and support the diagnosis of conditions such as polycystic o***y syndrome. Unlike other reproductive hormones, AMH levels show minimal variation during the menstrual cycle. In males, AMH is secreted by Sertoli cells during fetal life and childhood, playing a key role in male sexual differentiation.

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