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Medical Database

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Medical Database

Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from Medical Database, Medical and health, 7545 Irvine Center Drive, Suite 200, Irvine, CA.

We provide reliable and updated medical information to healthcare providers, insurance companies, and educational institutions and assist healthcare providers in making appropriate clinical decisions, meeting medical necessity, and maintaining compliance

03/27/2026

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthrough that enhances the precision and power of our platform.

We’re proud to be among the first to achieve this milestone in linking resistance data to specific pathogens, driving smarter and faster clinical insights.

03/26/2026

Fractional Excretion of Sodium (FENa) is a calculated value used to help differentiate causes of acute kidney injury, particularly prerenal azotemia and intrinsic renal damage such as acute tubular necrosis. It represents the percentage of sodium filtered by the kidney that is excreted in the urine. FENa is calculated using serum and urine sodium and creatinine concentrations. A FENa value less than 1% suggests prerenal causes such as dehydration, while a value greater than 2% suggests intrinsic renal damage. Values between 1–2% may be indeterminate. FENa may be unreliable in patients receiving diuretics, with chronic kidney disease, or in acute glomerulonephritis. It is most useful when interpreted alongside clinical findings and other laboratory results.

03/25/2026

MLH1 Hypermethylation (Promoter Methylation) Analysis is a molecular test used to detect epigenetic silencing of the MLH1 gene caused by promoter hypermethylation. This analysis is commonly performed on formalin-fixed, paraffin-embedded tissue, especially in colorectal and endometrial tumors showing loss of MLH1 protein expression by immunohistochemistry. Promoter methylation prevents gene transcription, leading to mismatch repair deficiency and microsatellite instability. The test helps distinguish sporadic tumors from Lynch syndrome-associated cancers, as MLH1 hypermethylation is typically seen in sporadic cases. Methods commonly used include methylation-specific PCR and pyrosequencing. Accurate detection is important for patient management, prognosis, and guiding further germline genetic testing and therapeutic decisions, including immunotherapy eligibility. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55c840d4-c76d-406b-9131-e045eb5d611b

03/21/2026

Inherited insulin resistance syndromes (INSR) genetic testing is used to diagnose rare genetic disorders caused by mutations in the insulin receptor (INSR) gene. These syndromes include severe insulin resistance conditions such as Donohue syndrome, Rabson-Mendenhall syndrome, and Type A insulin resistance. Genetic testing is typically performed using sequencing methods to detect point mutations, deletions, or insertions in the INSR gene. It is recommended for patients with severe hyperinsulinemia, poor response to insulin therapy, acanthosis nigricans, growth abnormalities, or early-onset diabetes. Identifying the mutation helps confirm diagnosis, guide treatment decisions, provide prognosis, and support genetic counseling for affected families. Early diagnosis is important for clinical management and monitoring of associated metabolic complications. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e2716-060b-433e-92e4-2db25c90473e

03/20/2026

Intrinsic factor antibodies (IFA) are autoantibodies directed against intrinsic factor, a glycoprotein secreted by gastric parietal cells that is essential for vitamin B12 absorption in the ileum. Their presence is a key marker for pernicious anemia, an autoimmune disorder leading to vitamin B12 deficiency and subsequent megaloblastic anemia. There are two main types of intrinsic factor antibodies: blocking antibodies, which prevent vitamin B12 from binding to intrinsic factor, and binding antibodies, which interfere with the intrinsic factor–vitamin B12 complex attaching to intestinal receptors. Testing for IFA is highly specific but moderately sensitive; not all patients with pernicious anemia have detectable antibodies. Early detection aids in diagnosis, management, and prevention of neurological complications from prolonged B12 deficiency. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e27be-1198-45e0-b24d-15fa3e64686e

03/18/2026

Gamma glutamyl transferase (GGT) is an enzyme primarily found in the liver, bile ducts, and kidneys. It plays a key role in glutathione metabolism by facilitating the transfer of gamma-glutamyl groups, which helps in antioxidant defense and detoxification processes. Clinically, GGT is widely used as a biomarker for hepatobiliary disorders. Elevated serum GGT levels are commonly associated with liver diseases such as hepatitis, cirrhosis, and bile duct obstruction. It is also sensitive to alcohol consumption and can be used to monitor alcohol-related liver injury. However, GGT lacks specificity and is often interpreted alongside other liver enzymes like ALT and ALP. Mild elevations may also occur in pancreatic disease, cardiovascular conditions, and with certain medications. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/?from=login

03/16/2026

Follicle Stimulating Hormone (FSH) is a glycoprotein hormone produced by the anterior pituitary gland. It plays a key role in regulating the reproductive system in both males and females. In females, FSH stimulates the growth and maturation of ovarian follicles in the ovaries and promotes estrogen production. Rising FSH levels during the menstrual cycle help select the dominant follicle that will release an egg during ovulation. In males, FSH acts on Sertoli cells in the te**es to support s***matogenesis and s***m maturation. Measurement of FSH in blood is commonly used to evaluate fertility, pituitary function, ovarian reserve, and certain endocrine disorders such as hypogonadism or menopause related changes in reproductive hormone balance and clinical diagnosis in reproductive medicine. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26fc-ab6b-4c82-ab5e-d6546734a7bc

03/13/2026

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and antibiotic resistance, generating real-time, guideline-oriented pharmacotherapeutic recommendations according to detected microbial load and antimicrobial resistance genes. Learn more about our products:
www.medicaldatabase.com

03/11/2026

The Hemoglobin S (HbS) screen is a laboratory test used to detect the presence of hemoglobin S, an abnormal form of hemoglobin associated with sickle cell disorders. It is commonly performed as an initial screening test for sickle cell trait and sickle cell disease, genetic conditions that affect oxygen carrying ability of red blood cells. The test is often carried out using methods such as sickle solubility testing or hemoglobin electrophoresis. In the presence of HbS, red blood cells can assume a sickle shape under low oxygen conditions, which may lead to hemolysis, anemia, and vascular complications. The HbS screen is widely used in newborn screening programs, blood donor testing, and clinical evaluations. Positive results typically require confirmatory testing to accurately identify the specific hemoglobin variant present. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55c67697-e510-4d60-bed9-314400d8c2c3

03/10/2026

Liver Cytosolic Antigen Type 1 (LC1) is an autoantigen targeted by specific autoantibodies known as anti-LC1 antibodies. These antibodies are primarily associated with type 2 autoimmune hepatitis (AIH-2), a chronic inflammatory liver disease that mainly affects children and young adults. LC1 corresponds to the enzyme formiminotransferase cyclodeaminase (FTCD), which is located in the cytosol of hepatocytes and plays a role in histidine metabolism and folate pathways. Detection of anti-LC1 antibodies is usually performed using immunoassays such as ELISA or immunoblot techniques. Although anti-LC1 antibodies may occur alone, they often appear together with anti-liver kidney microsomal type 1 (anti-LKM1) antibodies. Their presence supports the diagnosis of AIH-2 and helps differentiate it from other autoimmune liver disorders and viral hepatitis. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/56381e30-05df-487b-9639-0e3359b7027d

03/06/2026

The Catechol-O-methyltransferase (COMT) genotype refers to inherited variations in the COMT gene that influence the activity of the COMT enzyme, which is responsible for the degradation of catecholamines such as dopamine, epinephrine, and norepinephrine. A well-known polymorphism is the Val158Met polymorphism, where a valine (Val) is substituted by methionine (Met) at position 158 of the enzyme. This substitution significantly alters enzyme activity: the Val variant exhibits higher enzymatic activity and faster dopamine metabolism, whereas the Met variant results in lower activity and increased dopamine levels, particularly in the prefrontal cortex. COMT genotyping is widely used in pharmacogenomics and neuropsychiatric research, helping to understand individual differences in cognition, stress response, pain perception, and susceptibility to certain neurological or psychiatric disorders.

03/04/2026

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) for any given disease by meeting the medical necessity and, thereby improve reimbursement rates. Every order submitted using the Company's CPOE automatically will include the correct ICD10 and CPT codes and will be checked for Medicare LCDs and NCDs to ensure medical necessity is met.

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7545 Irvine Center Drive, Suite 200
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92618

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Monday	8am - 6pm
Tuesday	8am - 5pm
Wednesday	8am - 6pm
Thursday	8am - 6pm
Friday	8am - 6pm

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