Medical Database

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We provide reliable and updated medical information to healthcare providers, insurance companies, and educational institutions and assist healthcare providers in making appropriate clinical decisions, meeting medical necessity, and maintaining compliance

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and anti...
11/14/2025

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and antibiotic resistance, generating real-time, guideline-oriented pharmacotherapeutic recommendations according to detected microbial load and antimicrobial resistance genes. Learn more about our products:
www.medicaldatabase.com

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthr...
11/13/2025

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthrough that enhances the precision and power of our platform.

We’re proud to be among the first to achieve this milestone in linking resistance data to specific pathogens, driving smarter and faster clinical insights.

3,4-Methylenedioxymethamphetamine (M**A) is a psychoactive drug that acts as both a stimulant and a psychedelic, produci...
11/10/2025

3,4-Methylenedioxymethamphetamine (M**A) is a psychoactive drug that acts as both a stimulant and a psychedelic, producing increased energy, altered perception, and distortions in time. It is commonly used by adolescents and young adults because it lowers inhibitions and increases euphoria, empathy, emotional closeness, and sexual arousal. M**A is widely known as “Ecstasy,” although street formulations may contain additional drugs such as methamphetamine, ketamine, co***ne, dextromethorphan, ephedrine, or caffeine, making its effects unpredictable. At high doses, M**A interferes with thermoregulation, leading to sharp increases in body temperature and potentially resulting in liver, kidney, or cardiovascular failure. The drug is metabolized in the liver and excreted into urine, allowing detection through immunoassay, GC/MS, or LC/MS analytical methods. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26f5-3f43-4d64-86e5-722d9d2ca5dd

N-Acetyltransferase 2 (NAT2) Gene Mutation Analysis detects genetic variants in the NAT2 gene that influence the rate of...
11/07/2025

N-Acetyltransferase 2 (NAT2) Gene Mutation Analysis detects genetic variants in the NAT2 gene that influence the rate of drug acetylation. NAT2 encodes an enzyme responsible for metabolizing various drugs and xenobiotics, including isoniazid, hydralazine, and sulfonamides. Mutations in NAT2 affect enzyme activity, classifying individuals as slow, intermediate, or rapid acetylators. Slow acetylators are at increased risk of adverse drug reactions and toxicity, whereas rapid acetylators may experience reduced therapeutic efficacy. This test is performed using DNA extracted from blood or buccal cells and analyzed by PCR-based methods or sequencing. NAT2 genotyping aids in personalized medicine by guiding drug selection and dosage adjustments to minimize toxicity and optimize therapeutic response, especially in tuberculosis and cardiovascular treatments. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55c84829-b63a-41bb-8c8c-984f07500a68

Vitamin B1 (thiamin) is an essential vitamin that is involved in carbohydrate metabolism, brain function, and nerve myel...
11/05/2025

Vitamin B1 (thiamin) is an essential vitamin that is involved in carbohydrate metabolism, brain function, and nerve myelination. It is also necessary for the synthesis of the neurotransmitters GABA and acetylcholine. Vitamin B1 can be stored in the body. Since these stores are limited, deficiency can occur quickly. Minor deficiency can happen within 10 days and more severe deficiency within 21 days on a vitamin B1-restricted diet. Chronic alcoholics often have poor nutrition and often have thiamin deficiency, which is seen in about 80% of alcoholics. Deficiency can also be seen in the elderly, people with chronic gastrointestinal problems, anorexia, cancer, and those on diuretics. Vitamin B1 deficiency symptoms include poor sleep, malaise, weight loss, irritability, and confusion. More severe symptoms of vitamin B1 deficiency include impaired intellectual performance, congestive heart failure, peripheral neuropathy, and encephalopathy that can progress to coma or death. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26eb-34cc-41e8-8af2-20d5737bf1fe

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) f...
11/05/2025

Check out our Computerized Provider Order Entry (CPOE) specifically designed to help providers order the right test(s) for any given disease by meeting the medical necessity and, thereby improve reimbursement rates. Every order submitted using the Company's CPOE automatically will include the correct ICD10 and CPT codes and will be checked for Medicare LCDs and NCDs to ensure medical necessity is met.

The MYD88 gene encodes for the myeloid differentiation primary response 88 (MYD88) protein which is involved in toll-lik...
11/04/2025

The MYD88 gene encodes for the myeloid differentiation primary response 88 (MYD88) protein which is involved in toll-like receptor and interleukin-1 signaling in the immune response, cytokine secretion, and inflammatory response. Mutations in the MYD88 gene have been associated with Waldenström macroglobulinemia, an uncommon lymphoproliferative disorder, characterized by lymphoplasmacytic cells in the bone marrow and overproduction of monoclonal IgM. The mutations may also result in the production of a nonfunctional protein or no protein at all. As a result, the protein cannot relay signals that stimulate an immune response, which allows multiple severe infections to develop. Patients with MYD88 deficiency have an increased susceptibility to infections with pyogenic (pus producing) bacteria, most commonly, Streptococcus pneumoniae, Staphylococcus aureus and/or Pseudomonas aeruginosa. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/5ea4b7a6-1d8d-4ce0-af04-4256e2d8151a

High Density Lipoprotein (HDL) comprises a complex family of particles that vary in their lipid and protein composition....
11/01/2025

High Density Lipoprotein (HDL) comprises a complex family of particles that vary in their lipid and protein composition. Based on density gradient ultracentrifugation, HDL can be of two distinct subtypes; HDL2 (larger and buoyant) and HDL3 (smaller and dense). HDL2 is formed in circulation from HDL3 through the action of lecithin-cholesterol acyl transferase (LCAT) enzyme and HDL2 contains twice as many cholesterol molecules per unit of apolipoprotein compared to HDL3. These HDL subclasses are believed to play different roles in arteriosclerosis progression and regression. HDL2 has been suggested to be the more variable component of total HDL and several lines of evidence showed that it is the more anti-atherogenic form of HDL. Therefore, decreased levels of HDL2 cholesterol is associated with an increase in the risk of atherosclerotic cardiovascular disease. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55c6748e-8c3c-457f-805d-b34833b57547

The adrenal cortex, specifically the zona fasciculata and zona reticularis, synthesizes 11-deoxycortisol from 17-hydroxy...
10/30/2025

The adrenal cortex, specifically the zona fasciculata and zona reticularis, synthesizes 11-deoxycortisol from 17-hydroxyprogesterone. This intermediate is then converted into cortisol through the catalytic action of the enzyme 11β-hydroxylase. Consequently, quantifying 11-deoxycortisol in serum or plasma serves as a useful diagnostic marker for identifying 11β-hydroxylase deficiency, the second most common form of congenital adrenal hyperplasia (CAH). This enzyme defect leads to reduced cortisol synthesis, which stimulates excess secretion of adrenocorticotropic hormone (ACTH) from the pituitary gland. The impaired enzymatic conversion also causes accumulation of precursor steroids. Moreover, the drug metyrapone, which specifically inhibits 11β-hydroxylase, is employed in clinical settings to evaluate the integrity of the hypothalamic–pituitary–adrenal (HPA) axis by measuring post-administration levels of 11-deoxycortisol, ACTH, and cortisol. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55d8ff98-cfbd-46fe-a740-1a0383300407

BRCA1/2 germline testing is essential in breast cancer risk assessment and management. Mutations in these tumor suppress...
10/28/2025

BRCA1/2 germline testing is essential in breast cancer risk assessment and management. Mutations in these tumor suppressor genes impair DNA repair through homologous recombination, predisposing carriers to early-onset and bilateral breast cancers. Testing is recommended for patients with a family history of breast or ovarian cancer, triple-negative breast cancer diagnosed before age 60, or male breast cancer. Identifying a BRCA1 or BRCA2 mutation influences clinical decisions such as intensified surveillance with MRI, prophylactic mastectomy, or salpingo-oophorectomy. In metastatic or high-risk cases, PARP inhibitors offer targeted therapy exploiting defective DNA repair mechanisms. Genetic counseling is crucial to interpret results and guide cascade testing among relatives, promoting early detection and personalized preventive strategies against hereditary breast cancer. Learn more about the testing with Medical Database.

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