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Medical Database

Contact information, map and directions, contact form, opening hours, services, ratings, photos, videos and announcements from Medical Database, Medical and health, 7545 Irvine Center Drive, Suite 200, Irvine, CA.

We provide reliable and updated medical information to healthcare providers, insurance companies, and educational institutions and assist healthcare providers in making appropriate clinical decisions, meeting medical necessity, and maintaining compliance

04/09/2026

The fructosamine test measures glycated serum proteins, primarily albumin, to assess average blood glucose levels over the previous 2–3 weeks. Unlike Hemoglobin A1c, which reflects longer-term control (2–3 months), fructosamine provides a shorter-term view, making it useful for monitoring recent changes in diabetes management or during pregnancy. It is particularly helpful when conditions affecting red blood cells, such as anemia or hemoglobin variants, interfere with HbA1c accuracy. Results are influenced by serum protein levels; therefore, disorders like Nephrotic Syndrome or liver disease may affect interpretation. Overall, fructosamine is a valuable adjunct test for short-term glycemic monitoring. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e2724-7999-4851-a7e9-5dce1e1e915d

04/07/2026

Glomerular basement membrane (GBM) antibodies are autoantibodies directed against components of the basement membrane in the kidney glomeruli, particularly the α3 chain of type IV collagen. These antibodies are central to the pathogenesis of anti-GBM disease, a rare but serious autoimmune condition that can cause rapidly progressive glomerulonephritis. In some cases, they also affect lung alveoli, leading to pulmonary hemorrhage, a presentation known as Goodpasture syndrome. Detection of GBM antibodies in blood is critical for diagnosis. Early identification allows prompt treatment with plasmapheresis, corticosteroids, and immunosuppressive therapy, which can help reduce antibody levels, limit kidney damage, and improve patient outcomes if initiated quickly. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26a9-8de4-479e-a24c-7c2e1301103e

04/06/2026

Ammonia blood testing measures the level of ammonia, a waste product of protein metabolism, in the bloodstream. Normally, the liver converts ammonia into urea, which is then excreted by the kidneys. Elevated ammonia levels, a condition called hyperammonemia, may indicate liver dysfunction, such as cirrhosis, hepatitis, or acute liver failure. It can also result from certain metabolic disorders, gastrointestinal bleeding, or urea cycle defects. The test is often used to evaluate unexplained confusion, lethargy, or suspected hepatic encephalopathy. Blood is typically collected in a heparinized tube and must be processed quickly or kept on ice to prevent falsely elevated results. Accurate testing requires careful handling, proper labeling, and timely transport to the laboratory. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26ae-5e21-4d64-9fb2-92281eccbbe0

04/01/2026

The PLN gene encodes phospholamban, a 52-amino acid membrane protein that regulates cardiac calcium handling by inhibiting ATP2A2 activity in the sarcoplasmic reticulum. Phospholamban modulates calcium reuptake during relaxation, maintaining cardiac diastolic function. Mutations in PLN are linked to inherited dilated cardiomyopathy (DCM) and familial hypertrophic cardiomyopathy (HCM). DCM involves ventricular dilation and impaired systolic function, potentially causing heart failure, arrhythmias, syncope, or sudden death, affecting ~1 in 2,500 adults; PLN mutations are a rare cause. HCM features unexplained left ventricular hypertrophy, disorganized myocardial fibers, and fibrosis, with variable symptoms from asymptomatic to severe cardiac events; PLN mutations account for

03/27/2026

🚀 Big news! Our latest update introduces direct mapping of antimicrobial resistance (ABR) genes to pathogens, a breakthrough that enhances the precision and power of our platform.

We’re proud to be among the first to achieve this milestone in linking resistance data to specific pathogens, driving smarter and faster clinical insights.

03/26/2026

Fractional Excretion of Sodium (FENa) is a calculated value used to help differentiate causes of acute kidney injury, particularly prerenal azotemia and intrinsic renal damage such as acute tubular necrosis. It represents the percentage of sodium filtered by the kidney that is excreted in the urine. FENa is calculated using serum and urine sodium and creatinine concentrations. A FENa value less than 1% suggests prerenal causes such as dehydration, while a value greater than 2% suggests intrinsic renal damage. Values between 1–2% may be indeterminate. FENa may be unreliable in patients receiving diuretics, with chronic kidney disease, or in acute glomerulonephritis. It is most useful when interpreted alongside clinical findings and other laboratory results.

03/25/2026

MLH1 Hypermethylation (Promoter Methylation) Analysis is a molecular test used to detect epigenetic silencing of the MLH1 gene caused by promoter hypermethylation. This analysis is commonly performed on formalin-fixed, paraffin-embedded tissue, especially in colorectal and endometrial tumors showing loss of MLH1 protein expression by immunohistochemistry. Promoter methylation prevents gene transcription, leading to mismatch repair deficiency and microsatellite instability. The test helps distinguish sporadic tumors from Lynch syndrome-associated cancers, as MLH1 hypermethylation is typically seen in sporadic cases. Methods commonly used include methylation-specific PCR and pyrosequencing. Accurate detection is important for patient management, prognosis, and guiding further germline genetic testing and therapeutic decisions, including immunotherapy eligibility. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/55c840d4-c76d-406b-9131-e045eb5d611b

03/21/2026

Inherited insulin resistance syndromes (INSR) genetic testing is used to diagnose rare genetic disorders caused by mutations in the insulin receptor (INSR) gene. These syndromes include severe insulin resistance conditions such as Donohue syndrome, Rabson-Mendenhall syndrome, and Type A insulin resistance. Genetic testing is typically performed using sequencing methods to detect point mutations, deletions, or insertions in the INSR gene. It is recommended for patients with severe hyperinsulinemia, poor response to insulin therapy, acanthosis nigricans, growth abnormalities, or early-onset diabetes. Identifying the mutation helps confirm diagnosis, guide treatment decisions, provide prognosis, and support genetic counseling for affected families. Early diagnosis is important for clinical management and monitoring of associated metabolic complications. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e2716-060b-433e-92e4-2db25c90473e

03/20/2026

Intrinsic factor antibodies (IFA) are autoantibodies directed against intrinsic factor, a glycoprotein secreted by gastric parietal cells that is essential for vitamin B12 absorption in the ileum. Their presence is a key marker for pernicious anemia, an autoimmune disorder leading to vitamin B12 deficiency and subsequent megaloblastic anemia. There are two main types of intrinsic factor antibodies: blocking antibodies, which prevent vitamin B12 from binding to intrinsic factor, and binding antibodies, which interfere with the intrinsic factor–vitamin B12 complex attaching to intestinal receptors. Testing for IFA is highly specific but moderately sensitive; not all patients with pernicious anemia have detectable antibodies. Early detection aids in diagnosis, management, and prevention of neurological complications from prolonged B12 deficiency. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e27be-1198-45e0-b24d-15fa3e64686e

03/18/2026

Gamma glutamyl transferase (GGT) is an enzyme primarily found in the liver, bile ducts, and kidneys. It plays a key role in glutathione metabolism by facilitating the transfer of gamma-glutamyl groups, which helps in antioxidant defense and detoxification processes. Clinically, GGT is widely used as a biomarker for hepatobiliary disorders. Elevated serum GGT levels are commonly associated with liver diseases such as hepatitis, cirrhosis, and bile duct obstruction. It is also sensitive to alcohol consumption and can be used to monitor alcohol-related liver injury. However, GGT lacks specificity and is often interpreted alongside other liver enzymes like ALT and ALP. Mild elevations may also occur in pancreatic disease, cardiovascular conditions, and with certain medications. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/?from=login

03/16/2026

Follicle Stimulating Hormone (FSH) is a glycoprotein hormone produced by the anterior pituitary gland. It plays a key role in regulating the reproductive system in both males and females. In females, FSH stimulates the growth and maturation of ovarian follicles in the ovaries and promotes estrogen production. Rising FSH levels during the menstrual cycle help select the dominant follicle that will release an egg during ovulation. In males, FSH acts on Sertoli cells in the te**es to support s***matogenesis and s***m maturation. Measurement of FSH in blood is commonly used to evaluate fertility, pituitary function, ovarian reserve, and certain endocrine disorders such as hypogonadism or menopause related changes in reproductive hormone balance and clinical diagnosis in reproductive medicine. Learn more about the testing with Medical Database.
https://app.medicaldatabase.com/site/medical-tests/559e26fc-ab6b-4c82-ab5e-d6546734a7bc

03/13/2026

LDS®Rx® is a user-friendly analytical tool that employs a sophisticated algorithm to interpret syndromic panels and antibiotic resistance, generating real-time, guideline-oriented pharmacotherapeutic recommendations according to detected microbial load and antimicrobial resistance genes. Learn more about our products:
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