Felice Gersh MD

02/13/2026

I’m thrilled to be part of Fellowship in Longevity Medicine Module I: Endocrine and Cardiometabolic Health Mastery - focused on the intricate connections between hormonal health, metabolic function, and cardiovascular wellness.

Join me in West Palm Beach, FL at the Hilton West Palm Beach | April 10-12, 2026 to master cortisol regulation, thyroid function, blood sugar management, and evidence-based interventions for lasting patient wellness. ✨ Transform patient outcomes through hormonal and metabolic balance optimization.

🔗 Register now: https://www.a4m.com/module-i-2026.html
LINK IN BIO

02/12/2026

If you haven’t noticed, I don’t prescribe hormones the way most doctors do, and you probably have questions. I get a lot of questions about what cyclic hormones are, why I prescribe this way, and lots of questions about the nuts and bolts of how this works. And most importantly:

Are cyclic hormones right for you?

Send me your questions and if I don’t get to them tonight, I’ll try to do another round of top questions. I can’t give out patient-specific advice over the internet, but lots of people share questions and I want to give out as much info as I can.

A few questions I’ll try to get to:
* Did I invent the cyclic hormone protocol?
* Why do I prefer cyclic over standard, static hormone dosing?
* Are cyclic hormones safe?
* Will you still need vaginal estrogen?

⏰ Live Thursday, tune in for my talk.

Thurs, 2/12 at 7:30 PM Pacific
Watch live on Instagram.
Or check YouTube for the recording in a few days.

I’ll be checking Instagram for questions so if you have any additional questions that you’d like me to address, please add them to the comments of this post.

Let me know what questions you have! And tune in for this upcoming talk!

02/10/2026

My latest talk!
How progesterone protects the uterus:
Endometrial cancer risks and symptoms.
Plus what it means for hormone therapy in menopause.
https://youtu.be/-JvwE8fl16Q

In this talk, I explain how the uterine lining—the endometrium—normally grows and sheds, and what goes wrong when estrogen and progesterone are out of balance. I walk through the menstrual cycle, showing how estradiol acts as the growth signal and progesterone serves as the critical regulator that stops overgrowth and allows healthy shedding.

I clarify why endometrial cancer is rare in young women with regular cycles, why it occurs most often in postmenopausal women who are not on hormones, and how unopposed estrogen plus inflammation drives abnormal growth. I also explain endometrial hyperplasia—both simple and atypical—how it develops, how often it progresses, and why abnormal bleeding should always be evaluated but not automatically feared.

Finally, I discuss how physiologic, cyclic estradiol and progesterone therapy can lower inflammation, restore normal endometrial behavior, and reduce risk when properly monitored. Understanding how the uterus responds to hormones is essential for safe, effective hormone therapy at every stage of life.

In this talk, I explain how the uterine lining—the endometrium—normally grows and sheds, and what goes wrong when estrogen and progesterone are out of balanc...

02/09/2026

Alternatives to oral progesterone: protect the uterus without increasing appetite

If you take progesterone orally, a huge amount gets converted in the liver into allopregnanolone. Way more than your body would naturally make. And that can dysregulate appetite, drive carb cravings, and push overeating. And honestly, none of us want that.

So what do I recommend instead? Vaginal progesterone. We have a ton of data on this. It’s used every day in fertility clinics, IVF patients, all the time. It’s well studied and well absorbed.

It can also be used rectally, especially overnight. Same pill. Different route.

I really encourage you to talk with your practitioner about options, cyclic use, and choosing the route that works with your biology—guided by the science.

Learn more, watch my full talk,
Progesterone, Appetite, & Weight:
What women in menopause need to know about HRT
https://youtu.be/d7kDuTQrDO0

02/09/2026

How oral progesterone can increase appetite

Progesterone for menopausal hormone therapy is most often prescribed as an oral pill. And that matters. Because once you swallow it, it takes a first pass through the liver, where up to 80–90% is converted into other metabolites before it ever reaches the rest of the body.

One of the main metabolites is allopregnanolone. It’s not progesterone, but it’s made from it. And it has very real effects, especially in the brain.

Allopregnanolone has been studied as a driver of hyperphagia. Meaning increased appetite, stronger hunger signals, and a pull toward high-fat, high-sugar foods.

Learn more, watch my full talk,
Progesterone, Appetite, & Weight:
What women in menopause need to know about HRT
https://youtu.be/d7kDuTQrDO0

02/09/2026

The PMS-progesterone-carb binging connection

What is it about the luteal phase, that second half of the menstrual cycle, that causes some women to gain weight? Progesterone rises here, and for most women, weight changes are minimal. Maybe a little fluid retention or a little bloating which is actually pretty normal.

But for women with significant PMS, something else may be happening. Progesterone can be converted into allopregnanolone, especially in the brain. And some women either make more of it, or are simply more sensitive to it.

This helps explain carb and sugar cravings during the luteal phase. Bread, sweets, quick glucose hits. Those cravings aren’t a lack of willpower—they’re brain chemistry.

And understanding this has implications for menopausal hormone therapy.

Learn more, watch my full talk,
Progesterone, Appetite, & Weight:
What women in menopause need to know about HRT
https://youtu.be/d7kDuTQrDO0

02/05/2026

If you have a uterus and are taking menopausal hormone therapy, you have probably been told that you need to take progesterone to protect your uterus.

Let’s take a deeper look at endometrial hyperplasia, the condition you are protecting against. What are the symptoms and the risks? How can this lead to cancer? How does progesterone work? And what are your options for maximizing the benefits of hormone therapy while protecting your uterus?

⏰ Live Thursday, tune in for my talk.

Thurs, 2/5 at 7:30 PM Pacific
Watch live on Instagram.
Or check YouTube for the recording in a few days.

I’ll be checking Instagram for questions so if you have any additional questions that you’d like me to address, please add them to the comments of this post.

Let me know what questions you have! And tune in for this upcoming talk!

02/04/2026

So excited to bring PCOS SOS to my Portuguese speaking audience!

by

Durante a última edição do nosso Seminário Internacional, a Dra. Felice Gersh (referência mundial em ginecologia e medicina hormonal) participou do lançamento da versão em português de seu livro ‘SOS SOP’, publicada pela Editora Longevidade.

A obra, agora acessível ao público brasileiro, apresenta uma abordagem clínica e baseada em evidências para o manejo da Síndrome dos Ovários Policísticos (SOP), o distúrbio endócrino mais comum entre as mulheres em idade reprodutiva.

Com linguagem clara e conteúdo aplicável à prática médica, ‘SOS SOP’ oferece um novo olhar sobre a saúde feminina e reforça a importância de compreender as causas metabólicas e hormonais por trás da síndrome.

📖 Uma leitura obrigatória para todo médico que deseja, de fato, fazer a diferença na vida de suas pacientes.

Disponível em nossa Loja do Tempo!

👉 .

02/04/2026

The Fasting Mimicking Diet may improve cancer treatment outcomes!

Now, what about cancer studies? This is where things get really interesting. We now have both preclinical data and early human trials, phase one and phase two, looking at the Fasting Mimicking Diet as an adjunct to chemotherapy. And that word matters: adjunct. This is about supporting treatment, not replacing it.

Healthy cells have a remarkable ability to slow down, almost like entering a hibernation state. Cancer cells can’t do that. So during fasting, chemotherapy becomes less damaging to healthy cells and more lethal to cancer cells.

In melanoma and other early studies, the results have been very encouraging. This opens the door to larger trials. The potential here is incredibly exciting.

Learn more, watch my full talk,
Fasting Mimicking Diet: Science, benefits, and tips for success
https://youtu.be/v9UMA_QiNA8