09/24/2025
The American College of Rheumatology (ACR) recommends:
✨ Before Pregnancy
▪️ Keep lupus quiet & controlled for 6+ months before conceiving
▪️ Continue hydroxychloroquine (HCQ) – lowers flares & protects baby
▪️ Switch to pregnancy-safe meds → azathioprine, tacrolimus, cyclosporine
▪️ Test for antiphospholipid antibodies → ↑ clot/fetal loss risk
▪️ If Anti-Ro/SSA or Anti-La/SSB antibodies → baby needs close heart monitoring
✨ During Pregnancy
▪️ Stay on HCQ – reduces flares & steroid use
▪️ Start low-dose aspirin (81mg) late 1st trimester → ↓ preeclampsia risk
▪️ Close monitoring: kidneys, BP, fetal growth
▪️ Team up with a high-risk OB experienced in lupus pregnancies
▪️ Mild flares are common → usually manageable with safe therapy
⚠️ Avoid these meds: mycophenolate, methotrexate, leflunomide, cyclophosphamide
💊 If steroids are needed → use the lowest effective dose
đź’ˇ With the right plan, lupus pregnancy can be safe for mom & baby.