Total Ankle Trainer

12/22/2025

Yup

12/19/2025

12/18/2025

12/18/2025

On this day, two brothers proved that persistence, curiosity, and courage can lift humanity off the ground. ✈️
From a dream in the sand dunes to the dawn of flight here’s to daring to believe that the impossible is just waiting to take off.

Happy Wright Brothers Day

12/17/2025

One of the world’s oldest blood pressure drugs, hydralazine, was shown by researchers at the University of Pennsylvania, led by Dr. Megan Matthews and Dr. Kyosuke Shishikura, to halt the growth of aggressive brain tumors. In their study published in Science Advances (November 2025), the team treated human glioblastoma cells with hydralazine and found that within three days, the cells entered senescence, a permanent non-dividing state that stops tumor growth without killing the cells.

The Penn-led researchers discovered that hydralazine works by directly inhibiting the oxygen-sensing enzyme 2-aminoethanethiol dioxygenase (ADO). Using X-ray crystallography with collaborators at the University of Texas, they showed the drug binds to ADO’s metal center, blocking its activity.

Further testing with neuroscientists at the University of Florida revealed that shutting down this pathway prevents glioblastoma cells from surviving in low-oxygen environments, uncovering a shared biological mechanism between preeclampsia and brain cancer.

12/17/2025

Troops of U.S. 82nd Airborne Division marching behind an M4 Sherman tank in a snowstorm toward German-occupied town of Herresbach, Belgium, on January 29, 1945.

12/13/2025

Go Navy!

12/12/2025

Have a great weekend. We are now selling worldwide and will be introducing more products in the new year. TheTotalAnkle.com
Be safe and God bless. Total Ankle Trainer team.

12/12/2025

#1 & #3 for me

12/12/2025

A U.S Navy corpsman tending to a wounded U.S. Marine while using a rifle as makeshift plasma holder on Okinawa in May, 1945.

12/09/2025

USMC mechanics overhaul a Grumman TBF Avenger on Bougainville. A 2,000lb bomb waits to be loaded. February, 1944.