03/21/2026
I’ve stressed the importance of cross training for years. As we age we lose 3-5% of our muscle mass per decade beginning as early as 30. Muscle mass helps boost HDL (good cholesterol) and increases your metabolic rate (how fast your burn calories at rest). Strength is beautiful and helps support health and longevity.
Strength training targets neuroplasticity, inflammation and hormonal health helping to protect the aging female brain. By building muscle, women can trigger biological processes that directly protect brain structures like the hippocampus-the area most vulnerable to Alzheimer’s and dementia.
To elaborate, muscle contractions during strength training stimulate the release of proteins like Brain-Derived Neurotrophic Factor (BDNF) and Insulin-like Growth Factor 1 (GF-1). These act as “fertilizer” for the brain, promoting growth, survival and repair of neurons.
Recent studies suggest strength training actually helps the brain clear out amyloid-beta plaques-the toxic protein buildups that are hallmarks of Alzheimer’s. Also, strength training helps reduce inflammation and chronic, low-grade inflammation is a major risk factor for dementia. Strength training helps mobilize anti-inflammatory T-cells and lowers pro-inflammatory cytokines, creating a more protective environment for brain cells.
For women, strength training can be particularly impactful during and after menopause. It can help upregulate estradiol secretion, which works synergistically with IGF-1 to maintain both muscle mass and cognitive function.
Higher muscle mass is a strong predictor of better cognitive trajectories in women. Conversely, sarcopenia (age-related muscle decline) is linked to a faster executive function decline.
PMID: 29540588