Mark Liponis, M.D.

10/19/2023

The paper is a little dense, but researchers have identified a possible genetic explanation for the Hunter Farmer Diet Solution:

"Functional studies indicated that CHC22-V1316, which is more frequent in farming populations than in hunter-gatherers, has different cellular dynamics than M1316-CHC22 and is less effective at controlling GLUT4 membrane traffic, altering its insulin-regulated response."

Natural selection shaped CHC22 clathrin genetic variation in humans with different diets and potentially influenced the human insulin response.

05/21/2023

https://www.sciencedaily.com/releases/2023/05/230516115521.htm

Hmm... it's coming fast!

The latest version of ChatGPT passed a radiology board-style exam, highlighting the potential of large language models but also revealing limitations that hinder reliability, according to two new research studies.

05/16/2023

I'm looking forward to participating in this panel discussion this Thursday on the Future of Medicine and Longevity! You can join in person, or online! Here are some links:

https://www.eventbrite.com/e/longevity-technology-and-the-future-of-medicine-in-person-tickets-524613782947

https://www.eventbrite.com/e/longevity-technology-and-the-future-of-medicine-online-tickets-524640071577

03/16/2023

https://www.medscape.com/viewarticle/989475

"Poison is in the dose"...

In the Master@Heart observational study, lifelong endurance athletes had more coronary plaques, including more noncalcified plaques, than those with a similarly low cardiovascular risk profile.

03/09/2023

Mind... blown... 😳😳😳

Regulatinginflammation – THROUGH THE NERVOUS SYSTEM. SetPoint Medical is transforming the treatment of chronic autoimmune conditions to offer patients and providers a potentially safe and cost-effective treatment approach. GROUNDBREAKING SCIENCE The convergence of extraordinary advances in immunol...

01/13/2023

https://www.cnn.com/2022/06/02/health/reverse-aging-life-itself-scn-wellness/index.html

Hold on to your hats! Wowza!

Scientists around the world are scurrying to reverse the hands of time. Here's a look at one lab's search for the fountain of youth, where old mice have grown young again.

01/10/2023

https://www.nepm.org/regional-news/2023-01-06/caring-health-center-offers-medical-care-comfort-to-refugee-families-arriving-in-massachusetts

I'm so proud of the amazing difference my wife is always making! You are the best!

Caring Health Center, based in Springfield, Massachusetts, provides live interpreters, who speak 17 different languages, to assist refugees during medical examinations.

01/04/2023

https://jamanetwork.com/journals/jama/fullarticle/2799870
Only aspirin, anti-platelet therapy, and IL-6 blockers like Actemra were effective in reducing mortality in severe COVID19. Hydroxychloroquine worsened outcomes.

This secondary analysis of an ongoing adaptive platform trial examines the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes.

09/27/2022

Dear coffee lovers,

You're welcome.
☕️☕️☕️

06/22/2022

Hm... could that be.... true?

Scientists say for non-pregnant, otherwise healthy Americans, vitamins are a waste of money because there isn't enough evidence they help prevent cardiovascular disease or cancer. They've written an editorial in support of new recommendations that state there was 'insufficient evidence' that taking....

04/21/2022

Pick up the pace if you can! 🚶‍♂️🚶

A new study of genetic data of more than 400,000 UK adults has revealed a clear link between walking pace and a genetic marker of biological age.

02/08/2022

Love this kind of logical, out-of-the-box thinking! ❤❤https://www.sciencedaily.com/releases/2022/02/220207172952.htm
Pacemakers programmed with heart rate variability improve heart failure!

A revolutionary pacemaker that re-establishes the heart's naturally irregular beat is set to be trialled in New Zealand heart patients this year.