01/03/2024
Hello,
We are looking for volunteers that are currently on medications for opioid use disorder, specifically buprenorphine (all formulations, including suboxone, sublocade, and subutex) for a research study at NIH. We are also recruiting volunteers who are in recovery/abstinent and not currently taking medications for OUD (minimum 3 months). The study is attractive to participants because it pays them $1500+ over the course of about 4 non-consecutive days (spaced out and we are flexible with people’s schedules). They can either stay with us as an inpatient at the NIH for a few consecutive days, or they can visit each day as an outpatient and space the study days out. They are compensated on a prepaid debit card at the end of each study day. It gives patients a chance to participate in meaningful activities with professionals who like you, know very well the stigma one faces with OUD, especially in the clinical setting. The study consists of a screening day (which offers a substantial medical workup at no cost to volunteers) and two scanning days (MRI and PET scans). For the PET scans, we administer a small oral dose of Ritalin or placebo to measure dopamine increases in the brain. Most participants with OUD do not feel any effects of this dose. The procedure is very common in this type of research and has been performed safely for decades. Our healthcare professionals perform close monitoring for several hours after the dose is given to ensure patient safety. We also follow-up with volunteers within 3 business days of each visit
What we hope to show: That medications for OUD are NOT just ‘substituting one drug for another’, that they act differently from heroin/fentanyl. We want to see if they buy the brain some time to heal, restoring the imbalance of dopamine receptors that is seen in various substance use disorders, and thereby show some clear biological evidence for the efficacy of medications for OUD. We hope this will reduce the stigma around the medications and give us vital information on how the brain works.
If you are interested, we can set up a Zoom meeting with your house and/or staff.
Please let me know your thoughts and any questions you may have.
I can be reached via email or the following number: 301-646-5581. Looking forward to speaking to you soon.
Sincerely,
Leah Vines (she/her)
Post-Baccalaureate IRTALab of Neuroimaging
National Institute of Alcohol Abuse and Alcoholism
National Institutes of Health