03/26/2025
BeiCell Human Chemical Reprogramming Kit 2.0 (2nd Gen) for Faster and More Efficient Cell Reprogramming
Posted by Author on Tuesday 25 March, 2025
Human Chemical Reprogramming Kit 2.0 (2nd Generation), a rapid, efficient, and stable tool for reprogramming mesenchymal cells or fibroblasts from adipose, skin, and umbilical cord tissues.
Based on the latest breakthroughs from Peking University (Guan et al., Nature, 2022; Liuyang et al., Cell Stem Cell, 2023; Wang et al., Nature Chemical Biology, 2025), this kit enables the stable induction of human chemically induced pluripotent stem cells (CiPS cells) without transgenic modification, using small molecules to precisely regulate cell states.
Breakthrough in Chemical Reprogramming
A recent study (Nature Chemical Biology, Jan 3, 2025) by Professors Deng Hongkui and Guan Jingyang identified key epigenetic barriers, optimizing the system to reduce reprogramming time from 30 days to as little as 10 days, with a maximum efficiency of 38%. Even hard-to-reprogram cells showed a 20-fold improvement within 16 days, enhancing its broad applicability.
Key Advantages
✅ Simple Operation–Requires only medium exchanges
✅ High Efficiency–20-day induction, up to 38% efficiency
✅ Broad Applicability–Works across genetic backgrounds & ages
✅ Safe & Reliable–No genomic integration, eliminating immunogenic risks
✅ Standardized Production – Serum- & feeder-free, ensuring reproducibility
Human CiPS Cell Preparation
This multi-stage process requires no viral vectors or electroporation. Cells undergo three induction phases using specialized culture media, transforming into CiPS cells through morphological changes and immunofluorescence tracking.
Product & Storage Information
For Research Use Only – Not for clinical applications
Storage – Medium can be stored at 4°C (2 weeks) or -20°C (1 year, aliquoted)
