11/26/2025
Platelet-rich plasma (PRP) promotes tendon healing and repair through several key mechanisms:
- Delivers concentrated growth factors (e.g., PDGF, TGF-β, VEGF) that stimulate tenocyte proliferation, migration, and extracellular matrix synthesis, especially collagen I, which is critical for tendon strength and structure
- Enhances differentiation of tendon stem/progenitor cells into active tenocytes, increasing collagen production and accelerating tissue regeneration.
- Modulates inflammation by reducing pro-inflammatory cytokines and favoring M2 macrophage polarization, creating a regenerative microenvironment.
- Promotes angiogenesis, supporting vascular remodeling and improved nutrient delivery to the healing tendon.
- Increases antioxidant defenses in tenocytes via activation of the Nrf2 pathway, protecting cells from oxidative stress and supporting homeostasis.
- Improves tendon tissue organization, cellularity, and glycosaminoglycan content, leading to more mature and structurally sound tendon repair.
- Recruits stem cells to the wound area through chemoattractant proteins such as HMGB1, further enhancing tissue regeneration.
These combined actions establish a microenvironment that supports both structural and functional tendon recovery, though clinical efficacy may vary depending on PRP preparation and application protocols. 🏋️♀️