08/14/2025
More info ….
Sublingual (SL) ketamine — dissolves under the tongue — can offer several potential benefits for people with depression, especially treatment-resistant depression.
⸻
Key Benefits of SL Ketamine for Depression
1. Rapid Symptom Relief
• Many patients experience noticeable mood improvement within hours to days, compared to traditional antidepressants which can take weeks.
• Can help reduce severe symptoms, including suicidal thoughts, relatively quickly.
2. Non-Invasive & Convenient
• No needles or IVs; taken under provider guidance with concurrent therapy.
• Often used as part of a structured treatment plan that includes follow-up and monitoring.
3. Neuroplasticity Boost
• Ketamine helps promote new neural connections in the brain, potentially reversing patterns associated with depression.
• This “reset” effect may make therapy and lifestyle changes more effective.
4. Alternative for Treatment-Resistant Depression
• Useful for individuals who haven’t responded well to SSRIs, SNRIs, or other conventional medications.
5. Fewer Systemic Side Effects
• SL dosing often uses lower amounts compared to IV infusions, which may reduce side effects like blood pressure spikes or dissociation.
• Typically well-tolerated with proper dosing and supervision.