10/31/2025
Autistic children are valued members of our communities, deserving of support driven by high-quality research. Though preliminary studies have suggested the potential benefit of leucovorin for some autistic children, the evidence base remains too limited to support a wider recommendation. Questions on its benefits, dosing, appropriate monitoring and potential long-term impacts remain unanswered. Larger trials are needed to determine whether leucovorin is a safe and effective option for the autistic pediatric population.
AAP will update its guidance as evidence is compiled and encourages pediatricians to engage in shared decision-making with families asking about leucovorin while providing clear information about the evidence available and the potential risks. Learn more at the link below.
https://bit.ly/3WupJU7
