02/26/2026
Most antidepressants work on serotonin. But what if your depression isn't primarily a serotonin problem?
That's the question that changed everything in modern mental health treatment.
Here's what the science shows: traditional medications (SSRIs and SNRIs) increase serotonin availability in the brain. For many people, that helps. But for roughly 30% of patients, it doesn't — because their depression involves a different neurotransmitter system: glutamate.
Glutamate is the brain's most abundant excitatory neurotransmitter. It plays a critical role in learning, memory, and neural connectivity. When glutamate pathways are disrupted, the brain's ability to form and maintain healthy connections breaks down.
Infusion therapy works on this glutamate system. Instead of slowly adjusting serotonin over weeks, it helps restore neural connectivity through a process called neuroplasticity — your brain's built-in ability to repair and rebuild.
That's why patients who've tried everything else, sometimes experience improvement in hours or days rather than weeks or months.
Different mechanism. Different pathway. Different results.
Bay Area Ketamine Center - Call (415) 236-3431 Located at 746 Altos Oaks Drive Suite B, Los Altos, CA 94024 https://www.bayareaketaminecenter.com/