Soma Syntax Studio

05/01/2023

11/21/2021

Pressure sensitive receptors in the hands 🙌 👋

The Nobel Prize research awarded on October 4th, 2021 is very supportive of our work. Be sure to read the full press release information and the advanced information (links below) as it goes into the detail of explaining the molecular basis for sensing heat, cold and mechanical force, which is fundamental for our ability to feel, interpret and interact with our internal and external environment.

Summary: They discovered a class of sensors via pressure- sensitive cells that respond to mechanical stimuli in the skin and internal organs.

Learn more:
Press release: http://ow.ly/fyFA50GLBg7
Advanced information: http://ow.ly/kcn350GLBla

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Ardem Patapoutian, awarded the 2021 Nobel Prize in Physiology or Medicine, used pressure-sensitive cells to discover a novel class of sensors that respond to mechanical stimuli in the skin and internal organs.

Patapoutian and his collaborators first identified a cell line that gave off a measurable electric signal when individual cells were poked with a micropipette. It was assumed that the receptor activated by mechanical force is an ion channel and in a next step 72 candidate genes encoding possible receptors were identified. These genes were inactivated one by one to discover the gene responsible for mechanosensitivity in the studied cells. After an arduous search, Patapoutian and his co-workers succeeded in identifying a single gene whose silencing rendered the cells insensitive to poking with the micropipette. A new and entirely unknown mechanosensitive ion channel had been discovered and was given the name Piezo1, after the Greek word for pressure. Through its similarity to Piezo1, a second gene was discovered and named Piezo2. Sensory neurons were found to express high levels of Piezo2 and further studies firmly established that Piezo1 and Piezo2 are ion channels that are directly activated by the exertion of pressure on cell membranes.

The breakthrough by Patapoutian led to a series of papers from his and other groups, demonstrating that the Piezo2 ion channel is essential for the sense of touch. Moreover, Piezo2 was shown to play a key role in the critically important sensing of body position and motion, known as proprioception. In further work, Piezo1 and Piezo2 channels have been shown to regulate additional important physiological processes including blood pressure, respiration and urinary bladder control.

The 2021 Nobel Prize in Physiology or Medicine has been awarded jointly to David Julius and Ardem Patapoutian “for their discoveries of receptors for temperature and touch"

11/24/2019

💙Live Free, Age Well
🧘Relieve and Prevent Chronic Pain
💪Max your Athletic Performance

07/19/2018

She makes it look easy

08/05/2017

Remember exercise is great for depression. . .

“The way that people think about themselves is affected by depression,” Davey said.
“People with depression think about themselves more negatively, they spend more time thinking
about themselves, and have trouble switching between thinking about themselves and thinking
about the world outside them. Our findings find some brain basis for these difficulties.”

New neuroimaging research has found that depression is associated with abnormal function in an area of the brain known as the medial prefrontal cortex. The ...

07/29/2017

Jaw dropping, awe inspiring - Fierce Focus
“I knew that at that moment, it was important for me to just focus,” she said. “I really felt like I didn’t have time to deal with any extra emotions — any extra anything.” Ms. Williams added: “Pregnant or not, no one knew. Every tournament where I show up, I’m expected to win.”

Serena Williams won the Australian Open in her eighth week of pregnancy, a time when many women are dead tired and suffering from morning sickness.

07/29/2017

Oh, just when I was reaching for a cold one:
He suspects “that people susceptible to developing arrhythmias because of some undiagnosed condition might develop an arrhythmia under the stress of alcohol,” and that some could end up requiring treatment.

German scientists used Oktoberfest to show that moderate social drinking may lead to arrhythmias.

05/20/2017

Interesting article, if even for it's Comments. Here is one:

A Davis Chicago, IL February 15, 2017
Ms. Brody seriously misstates the current evidence for bariatric surgery by stating "it nearly always puts the disease into remission and slows or prevents the life-threatening damage it can cause to the heart and blood vessels", based on a current review synopsis in JAMA which I co-authored (jamanetwork.com/journals/jama/fullarticle/2601486 ). In fact, diabetes recurs in about 50%, most studies have only been for 2-3 years, and there are no randomized trials to date showing a reduction in cardiovascular diabetes complications from these surgeries. As far as the highlighted quote that "I've yet to come across a patient that wouldn't recommend it", I personally cared for a patient this week with potentially life-threatening complications after surgery at an outside institution. Major complications after bariatric surgery occur in 2-6%, and revisions and re-operations are required in up to 20%.

Andrew M Davis, MD. University of Chicago

Obese people who diet often regain the weight because their metabolic rate drops. That doesn’t happen with bariatric surgery.

05/09/2017

Memory and mood:

“If you ask physicians the best things to do to prevent age-related memory loss, they’ll say exercise,” Kandel points out. Does exercise help partly because it works to maintain bones, which make osteocalcin, which in turn helps preserve memory and mood?

Osteocalcin is a messenger, sent by bone to regulate crucial processes all over the body…

05/06/2017