01/04/2026
📘 New Publication | Clinical Research in Neurosurgery
I am pleased to share our recently published multinational study in Neurosurgery:
🧠 Risk Models for Adverse Events in Microsurgery for Intracranial Unruptured Aneurysms
This large international collaboration (PRAEMIUM Investigators) analyzed 3,705 patients from 20 high-volume microsurgical centers worldwide to develop and externally validate machine-learning–based risk prediction models for patients undergoing microsurgical treatment of unruptured intracranial aneurysms.
🔍 Key contributions
First externally validated models focused specifically on microsurgical risk
Personalized prediction of poor neurological outcome (mRS ≥3) and new sensorimotor deficits
Good calibration across multinational cohorts, supporting real-world clinical use
Designed to support objective risk assessment and patient counseling, complementing expert judgment
https://doi.org/10.1227/neu.0000000000003867
📄 Published online: December 5, 2025 | Open access
DOI: 10.1227/neu.0000000000003867
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