NeuroPointDX

10/24/2023

We are excited to share our latest work in autism research, recently published in Frontiers in Psychiatry from the Children’s Autism Metabolome Project (CAMP). The CAMP study is the largest study of the metabolism of children, ages 18 to 48 months with autism. Samples from 499 autistic and 209 typically developing children were collected in a highly annotated, case-controlled study and analyzed using quantitative liquid chromatography tandem mass spectrometry (LC/MS).



Fifty-four metabolites were evaluated including amino acids, organic acids, acylcarnitines, purines, and others. Biomarkers of metabolic dysregulation were found, each representing 4.5-11% of the autism group, but not found in typically developing children. Hierarchical clustering segregated the autistic children into 30 subtypes and revealed altered regulation of cellular metabolism, most notably involving mitochondrial energy-related processes.

Many autistic children were identified by multiple biomarkers and clusters and this increase in biomarker clusters was associated with increased autism severity based on the ADOS. These biomarkers identified 72% of the autistic children with 90% specificity.



This new paper builds on our previous work and provides new insights into subtypes of potential dysregulation in the metabolism of autistic children. Metabolomic analyses hold the promise for the discovery of biomarkers that may prove useful for diagnosis, clinical monitoring and ultimately understanding the causes of autism. Our hope is that this research will contribute to a precision medicine approach with the goal of more targeted and effective treatments for the challenges faced by autistic individuals.

Autism Spectrum Disorder (ASD or autism) is a phenotypically and etiologically heterogeneous condition. Identifying biomarkers of clinically significant metabolic subtypes of autism could improve understanding of its underlying pathophysiology and potentially lead to more targeted interventions. We....

02/15/2022

"Complex gastrointestinal issues in autism require more complex action. When your child is still suffering despite dietary intervention, supplementation, and remedies, it is time to find a qualified gastroenterologist."

Complex gastrointestinal issues in autism require more complex action. When your child is still suffering despite dietary intervention, supplementation, and remedies mentioned on the P**p Page, it is time to find a qualified gastroenterologist.

02/10/2022

The NPDX test is appropriate for a child who:⁣
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▪️Has failed screening for developmental milestones indicating risk for ASD (e.g. M-CHAT, ASQ-3, PEDS, STAT, etc.).⁣
▪️Has a family history such as a sibling diagnosed with ASD.⁣
▪️Has an ASD diagnosis for whom additional metabolic information may provide insight into the child’s condition and therapy.⁣ For more information: https://neuropointdx.com/providers/

02/08/2022

What if the physician or clinician suggests that we “wait and see” for 6-12+ months to see if my child catches up to peers?

Children develop skills like walking and talking at different times, so some physicians or clinicians may suggest a “wait and see” approach when a child shows delays.
Why this approach isn’t the best choice for your child:
An earlier diagnosis and treatment is important for a child’s short- and long-term development.
“Wait and see” can be frustrating for parents. It’s tough to wait it out when your child needs help. The NPDX ASD test offers an opportunity to identify and refer children at risk of an ASD diagnosis earlier so they can receive treatment sooner. Our test is an alternative to “wait and see.” If the test comes back positive, a physician or clinician should make the referral to a neurodevelopmental specialist with sound scientific support, based on clinical study that further testing could benefit the child — and should be performed sooner than later.

For more information: https://neuropointdx.com/faqs/

Read our Frequently Asked Questions (FAQs) from parents about the NeuroPointDX Autism Spectrum Disorder (NPDX ASD) blood test.

02/03/2022

NeuroPointDX uses metabolomics to identify people with autism. Through our extensive clinical study, the Children’s Autism Metabolome Project (CAMP), we identified several metabolic signatures that occur in about 63% of children with ASD. These metabolic signatures show certain amines are out of balance with one another. By measuring the levels of certain amines and comparing them to each other, we can provide an objective, biological indication of ASD.

For more information: https://neuropointdx.com/metabolomics-101/

02/01/2022

"A meta-analysis showed that almost 40% of kids with autism have at least one comorbid anxiety disorder. "

https://tacanow.org/family-resources/anxiety-in-autism/

Anxiety is very common in autism. A meta-analysis showed that almost 40% of kids with autism have at least one comorbid anxiety disorder. This article will discuss symptoms, calming strategies, medical and non-medical reasons for anxiety, and supplements and medications that can help alleviate it.

01/27/2022

Our test looks for certain metabolic imbalances that have been identified through our clinical study to be associated with autism. When we detect one or more imbalances there is an increased risk that the child will receive an autism diagnosis.
For more information: www.NeuroPointDX.com

01/25/2022

"Earlier identification and treatment for Autism Spectrum Disorder could lessen the severity of symptoms, according to the studies. "

https://amp.miamiherald.com/news/nation-world/national/article257023422.html

Earlier identification and treatment for Autism Spectrum Disorder could lessen the severity of symptoms, according to the studies.

01/20/2022

Our Mission 💫⁣
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We strive to improve the lives of children and families living with autism spectrum disorder and other neurological disorders by providing tools for earlier diagnosis and more precise treatment.⁣
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https://neuropointdx.com

01/18/2022

How do social behaviors impact children with autism?

https://www.autismparentingmagazine.com/social-behavior-interactions/

Social behavior and autism spectrum disorder can be challenging, with social difficulties ranging from speech and communication to eye contact.

01/13/2022

Sometimes parents and doctors wait months or years to see if a child will “catch up” to peers. In the meantime, valuable time is lost that could be used to begin helpful interventions. Ask your physician today to order NeuroPointDX’s NPDX ASD test.
https://neuropointdx.com/our-test/

01/11/2022

We improve the lives of children and families living with autism spectrum disorder (ASD) and other neurological disorders by providing tools for earlier diagnosis and more precise treatment.

https://neuropointdx.com/our-test/

Our autism blood tests for kids are two comprehensive metabolic panels that identifies metabolic subtypes associated with autism spectrum disorder.