02/02/2026
A German observational study followed 3,602 infertile women with PCOS who took a combined daily supplement of myo-inositol (4 grams) and folic acid for about 2–3 months, with an average use of around 10 weeks. During this period, approximately 70% of the women regained ovulation, indicating a meaningful improvement in ovarian function.
The return of ovulation was accompanied by improved fertility outcomes. A total of 545 pregnancies occurred, corresponding to a 15.1% pregnancy rate across the study population. In a subgroup analysis, hormone levels improved, with testosterone decreasing and progesterone increasing, and no significant side effects were reported, supporting good tolerability of the treatment.
PMID: 27642297