DeSoto Regional Health System

DeSoto Regional Health System DeSoto Regional Health System

DeSoto Regional Health System is comprised of an acute care, 38-bed, not-for-profit hospital, 3 rural health clinics, and wellness facility. DRHS provides a wide ranges of services and strives to create a comfortable, hometown environment while emphasizing compassionate, personal care. The DeSoto Regional Medical Staff includes 4 active-staff physicians, 3 employed nurse practitioners, 1 employed physician’s assistant, 117 courtesy physicians, 20 courtesy allied health professionals, and over 216 employees. Our areas of service include: Cardiology, Diagnostic Radiology, ENT, Emergency Medicine, Fitness/Wellness, Gastroenterology, Primary Care, General Surgery, Hematology/Oncology, Nephrology, Neurology, Ophthalmology, Orthopedics, Therapy Services, Podiatry, and Urology

Current Job Postings - February 6, 2026
02/06/2026

Current Job Postings - February 6, 2026

02/06/2026

Commemorative bricks at DeSoto Regional Health System offer a unique opportunity to leave your mark while supporting quality care in our community.

If you are interested or have questions, reach out to Terri Byrd at 318-872-4610 for more information.

Daily Lunch Menu - February 9-13, 2026
02/05/2026

Daily Lunch Menu - February 9-13, 2026

DeSoto Regional Health System is hosting a blood drive (platelet donations also accepted) today until 4:00pm in the Admi...
02/04/2026

DeSoto Regional Health System is hosting a blood drive (platelet donations also accepted) today until 4:00pm in the Administrative Conference Room of the hospital. Donate today!

A fresh chapter is literally being written into the framework at DeSoto Regional. Today, our Nursing and Rehabilitation ...
01/30/2026

A fresh chapter is literally being written into the framework at DeSoto Regional. Today, our Nursing and Rehabilitation teams left their signatures on the steel, marking their place in the future of care here at home.

Every name tells a story of long shifts, steady hands, and a commitment to helping patients heal and regain strength. It is a simple act, but a meaningful reminder that this new space is being built by the very people who will bring it to life each day.

Here’s to the teams shaping the next fifty years of care in our community.

Daily Lunch Menu - February 2-6, 2026
01/30/2026

Daily Lunch Menu - February 2-6, 2026

01/29/2026

UPDATE:

Fitness First will reopen tomorrow morning at 5:30 for regular operation

01/28/2026

UPDATE:

TheraTeam (located within Fitness First) will be open and seeing patients today starting at 10am; however, Fitness First gym will remain closed for the time being.

01/27/2026

UPDATE

Mansfield & Logansport clinic will open tomorrow at 10:00am.

Zwolle clinic will open at 8:00am

01/26/2026

UPDATE

DeSoto Regional Health System hospital will continue to care for inpatients and those coming to the emergency room for serious medical conditions. However, the Mansfield and Logansport clinics, including Industrial Medicine, Thera Team Physical Therapy, Business Office, and Surgical Services, will remain closed until Wednesday.

Our Zwolle Rural Clinic, located at 2026 Obrie Street, Zwolle, LA, will be open at 10am on Tuesday, January 27th.

DeSoto Regional Health System is grateful to the many employees who have sacrificed by staying overnight in the hospital to ensure patient care remains uninterrupted.

01/25/2026

Due to weather and unsafe driving conditions, all DRHS clinics will be closed on Monday, January 26.

We will share an update here if clinics are also closed on Tuesday.

If you have a medical emergency, please dial 911.

Address

207 Jefferson Street
Mansfield, LA
71052

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Our Story

DeSoto Regional Health System is comprised of an acute care, 38-bed, not-for-profit hospital, 3 rural health clinics, and wellness facility. DRHS provides a wide ranges of services and strives to create a comfortable, hometown environment while emphasizing compassionate, personal care. The DeSoto Regional Medical Staff includes 4 active-staff physicians, 3 employed nurse practitioners, 1 employed physician’s assistant, 117 courtesy physicians, 20 courtesy allied health professionals, and over 216 employees. Our areas of service include: Cardiology, Diagnostic Radiology, ENT, Emergency Medicine, Fitness/Wellness, Gastroenterology, Primary Care, General Surgery, Hematology/Oncology, Nephrology, Neurology, Ophthalmology, Orthopedics, Therapy Services, Podiatry, and Urology