02/13/2026
Derm Index: Everything You Need to Know About Kawasaki’s Disease
Kawasaki Disease (KD) is a rare, acute, self-limiting systemic vasculitis predominantly affecting infants and children. It is characterized by a febrile illness with associated mucocutaneous changes, including erythema of the mucous membranes, skin, and tongue, as well as swelling and desquamation of the hands and feet. Coronary artery involvement is the most significant complication of KD, which can lead to long-term cardiovascular issues. The etiology remains unknown, but it is hypothesized to involve genetic susceptibility and environmental triggers.
Epidemiology and Risk Factors
KD most commonly affects children under the age of 5, with a peak incidence at around 1 year of age and a mean age of 2.6 years. It is rare in children older than 8 years, and its incidence shows seasonal variation, peaking during the winter and spring months. KD is more common in boys than girls, and the condition is observed with a higher frequency in children of Asian descent, particularly in Japan. Although the exact cause is unknown, KD is believed to result from an interplay of genetic predisposition and an environmental trigger, potentially an infectious agent.
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