American Society of Pediatric Nephrology

11/21/2025

Immunogenicity of the 23-valent polysaccharide pneumococcal vaccine in children with steroid sensitive nephrotic syndrome

Background Idiopathic nephrotic syndrome (INS) is the most common chronic kidney disease in childhood, with steroid sensitive nephrotic syndrome (SSNS) as the predominant form. Children with SSNS are at increased risk for invasive pneumococcal disease due to disease-related and treatment-induced imm...

11/21/2025

Heart-kidney transplants linked to better outcomes compared to heart-only transplants in children with non-dialysis-dependent advanced chronic kidney disease

Background Chronic kidney disease (CKD) causes significant morbidity and mortality among children with heart failure. Although the survival benefit of a simultaneous heart-kidney transplant has been demonstrated in children with heart failure undergoing dialysis [1], the optimal intervention, simult...

11/21/2025

Background Ultrasonography (US) is the preferred first-line imaging modality for suspected urinary calculi in children because it is non-invasive and avoids radiation exposure. However, its diagnostic accuracy compared with non-contrast computed tomography (CT) remains variable, depending on stone l...

11/20/2025

Re-evaluating the MYH9 p.I1816V variant in a patient with atypical clinical presentation

MYH9-related disease (MYH9-RD) is an autosomal dominant disorder typically characterized by macrothrombocytopenia, leukocyte inclusion bodies, and variable non-hematologic manifestations such as hearing loss and nephropathy. We herein describe a 16-year-old boy presenting with persistent proteinuria...

11/20/2025

Correlation of serum beta-2 microglobulin with hemodialysis prescription and comorbid factors in children undergoing chronic hemodialysis

Background Hemodialysis (HD) is a method of kidney replacement therapy designed to remove uremic toxins from the body. Beta-2 microglobulin (beta-2 MG) is a middle molecule not yet effectively removed by conventional low-flux dialysis membranes and may contribute to long-term complications in chroni...

11/20/2025

Clinicopathological characteristics and cyclosporine-responsive proteinuria in nail-patella syndrome with a novel LMX1B mutation

Background Nephropathy in nail-patella syndrome (NPS) has limited therapeutic options. Progressive nephrotic-range proteinuria often persists despite maximal renin–angiotensin–aldosterone system inhibitor (RAASi) therapy. Calcineurin inhibitors such as cyclosporine A (CsA) are unexplored in NPS....

11/19/2025

The dietary management of sodium in children with kidney diseases—clinical practice recommendations from the Pediatric Renal Nutrition Taskforce

Sodium imbalance is a common concern in children with kidney diseases, presenting as either sodium excess or sodium deficit, each with significant clinical implications. Sodium excess contributes to fluid overload and hypertension, while increased sodium losses, particularly via urine or peritoneal....

11/19/2025

Relationships between galectin-3, sclerostin and arterial stiffness in children with renal scar

Background Renal scar can lead to hypertension and cardiovascular disease in children. Arterial stiffness is an important endpoint in the development of cardiovascular diseases and is a guide in the recognition of subclinical cardiovascular events. This study aimed to investigate oscillometric arter...

11/19/2025

From RAAS blockade to regenerative medicine: evolving treatment strategies in Alport syndrome (review)

Alport syndrome (AS) is a hereditary glomerulopathy caused by mutations in the COL4A3, COL4A4, or COL4A5 genes, leading to progressive kidney decline and extrarenal manifestations. Advances in genetic testing have enabled the reclassification of AS into X-linked, autosomal recessive, and autosomal d...

11/19/2025

Which glomerular filtration rate estimation equations should be used in youth with type 1 diabetes?

Background Diabetic kidney disease (DKD) is the primary cause of kidney failure in type 1 diabetes (T1D). Early identification of subclinical DKD is based on albuminuria and glomerular filtration rate (GFR). However, no GFR equations have been validated in youth with T1D. This study evaluates the pe...

11/19/2025

Giving monocytes their due: How CD47–SIRP-α reframes allograft rejection (review)

Despite decades of therapeutic innovation targeting adaptive immunity, such as the development of calcineurin inhibitors and B-cell–depleting agents like rituximab, long-term graft survival rates have stagnated, with nearly half of allografts failing within ten years. This enduring challenge under...

11/17/2025

Prolonged hypotension in children with bilateral kidney absence: a case series and pathophysiologic insights

Background The renin–angiotensin–aldosterone system is essential for blood pressure regulation, and its absence in children with bilateral kidney loss predisposes them to hypotension unresponsive to standard therapies. However, the longer-term hemodynamic consequences and neurologic risks in thi...