Dr. Henry Malus

10/18/2025

A timeline of genetic changes in millions of years of human evolution shows that variants linked to higher intelligence appeared most rapidly around 500,000 years ago, and were closely followed by mutations that made us more prone to mental illness.

The findings suggest a “trade-off” in brain evolution between intelligence and psychiatric issues, says Ilan Libedinsky at the Center for Neurogenomics and Cognitive Research in Amsterdam, the Netherlands.

“Mutations related to psychiatric disorders apparently involve part of the genome that also involves intelligence. So there’s an overlap there,” says Libedinsky. “[The advances in cognition] may have come at the price of making our brains more vulnerable to mental disorders.”

Read more: https://www.newscientist.com/article/2499487-evolution-of-intelligence-in-our-ancestors-may-have-come-at-a-cost/

Image: WHPics / Alamy

10/07/2025

🧠 Long COVID brain fog finally has a scientific explanation

For years, millions of people suffering from Long COVID have reported “brain fog”—trouble with memory, focus, and thinking clearly. Now, researchers in Japan have identified a biological cause behind these cognitive struggles.

A team at Yokohama City University used an advanced brain imaging technique called [11C]K-2 PET scanning to reveal abnormal increases in AMPA receptors (AMPARs)—molecules crucial for learning and memory—in patients with Long COVID. Elevated AMPAR levels were directly linked to both the severity of brain fog and higher inflammation markers, providing the first clear molecular evidence of the condition.

Published in Brain Communications (Oct 2025), the study found that AMPAR density could distinguish affected individuals from healthy ones with remarkable accuracy—100% sensitivity and 91% specificity. This breakthrough opens the door to new diagnostic tools and potential treatments, such as drugs targeting AMPAR activity.

With brain fog affecting over 80% of Long COVID patients worldwide, this discovery is a vital step toward validating patients’ experiences and accelerating the search for effective therapies.

📖 Reference: Yu Fujimoto et al., Systemic increase of AMPA receptors associated with cognitive impairment of long COVID, Brain Communications, 1 October 2025.

07/12/2025

Understanding Inflammaging

Chronic, low-grade inflammation—often called inflammaging—is a key driver of aging and disease. Your body's inflammatory load is shaped by many factors, including your genetics, diet, daily habits, environment, and personal health history.

**Inflammation is measurable—and modifiable**

By identifying and addressing your personal triggers, you can reduce systemic inflammation, enhance vitality, and potentially slow the aging process.

06/10/2025

https://www.sciencealert.com/several-psychiatric-disorders-share-the-same-root-cause-study-finds Several Psychiatric Disorders Share The Same Root Cause, Study Finds : ScienceAlert

Researchers recently discovered that eight different psychiatric conditions share a common genetic basis.

05/29/2025

New insights on genomes and phenomes are laying the groundwork for prevention and personalized care

05/10/2025

Ancestry is having a sale for Mother's Day.
39$ for basic report.

Sign up for a Nutrigenomic Report anytime between now and Mother's Day and get 10% off!

email: henry@malushealth.org for details.

02/01/2025

https://neurosciencenews.com/gut-brain-alzheimers-28398/

Scientists have used advanced X-ray phase-contrast tomography (XPCT) to uncover how gut health may influence Alzheimer’s disease.

01/30/2025

https://blog.microbiomeprescription.com/2025/01/29/ai-large-language-model-versus-fuzzy-logic-expert-system-for-the-microbiome

AI: Large Language Model versus Fuzzy Logic Expert System for the Microbiome In meetings with Vitract.com (Canada and US) and PrecisionBiome.Eu (the EU) leadership this week, given the low cost of the new DeepSeek Large Language Model (LLM) model came up. Both of these firms are working on implement...

01/27/2025

01/21/2025

Long-term static stretching and proprioceptive neuromuscular proprioceptive stretching produced a greater range of motion compared to dynamic/ballistic stretching.

It is well known that stretch training can induce prolonged increases in joint range of motion (ROM). However, to date more information is needed rega…