05/21/2025
We’re excited to share that the first patient has been treated in the Phase I/II trial of REJUVXL™️ cell therapy for Stage 3 CKD at the University of Miami. Huge thanks to Dr. Yelena Drexler, Dr. Alessia Fornoni, and the whole clinical team for making this milestone possible. Learn more here:
https://lnkd.in/dRWEbMxE
The study (NCT06721143), now underway at the University of Miami Health System, is progressing as planned in its evaluation of safety, tolerability, and early efficacy signals of AION Healthspan’s investigational cell therapy.
“This is an exciting and meaningful step in advancing this cell therapy approach to treating chronic kidney disease,” said Dr. Yelena Drexler, Principal Investigator on the CKD trial. “The successful completion of the investigational infusions for our first patient demonstrates our commitment to providing innovative therapies and paves the way for further critical observations and data collection. We are encouraged by the momentum and the support from both our patients and clinical team.”
AION Healthspan’s investigational therapy targets inflammation and fibrosis, the core drivers of kidney damage in CKD, with the goal of preserving or restoring renal function before the disease advances to dialysis or transplant.
“With the global rise in the prevalence of kidney disease, and the associated mortality rates often worse than the rates seen in oncology, the need for regenerative, disease-modifying treatments is urgent,” said Dr. Alessia Fornoni, nephrologist and member of AION’s Scientific Advisory Board. “We believe this approach, if successful, could represent a fundamental shift for CKD management.”