Environmental Health Sciences

07/02/2018

https://www.technologynetworks.com/genomics/news/genes-linking-alzheimers-and-down-syndrome-discovered-305399?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=64032492&_hsenc=p2ANqtz-9WlvFmkdWXQuRN2TCAs2nA0P2ZL7u_1rW6TowbJRMdA_wWUjp2YmiZg9KpQiSFqdQS60HhBmVOQWK4D5qDID75r0CQuA&_hsmi=64032492

06/24/2018

Congratulations to Drs Chao, Hu (visiting fellows in the Oxidative Stress Group), and Cooke, on the acceptance of the paper on cellular and urinary DNA adductomics in Archives of Toxicology:

Chang, Y-J., Cooke, MS., Hu, C-W. and Chao, M-R. Novel approach to integrated DNA adductomics for the assessment of in vitro and in vivo environmental exposures. Archives of Toxicology. (In press.).

06/14/2018

https://www.nature.com/articles/d41586-018-05255-1

In 1968, a defect in DNA repair was found to underlie a disorder that makes people extremely sensitive to sunlight. This finding continues to influence research into the origins, diagnosis and treatment of cancer.

06/14/2018

https://www.technologynetworks.com/neuroscience/news/exosomes-involved-in-spread-of-alzheimers-pathology-305071?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63756529&_hsenc=p2ANqtz-8x5ffJCjZGQLmQgq2S1mTtqG2dzOep_TeP2qt0SV2e63pQfG2v5IeQ5VOsi1ENEUHhZYBiJADSi7389n5hRPP5WTIcQQ&_hsmi=63756529

Exosomes can contain amyloid-beta oligomers, which other cells can absorb.

06/14/2018

https://www.technologynetworks.com/drug-discovery/news/new-ovarian-cancer-target-305059?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63756529&_hsenc=p2ANqtz-8x5ffJCjZGQLmQgq2S1mTtqG2dzOep_TeP2qt0SV2e63pQfG2v5IeQ5VOsi1ENEUHhZYBiJADSi7389n5hRPP5WTIcQQ&_hsmi=63756529

Researchers have found a prescription drug, Calcitriol, approved by the Food and Drug Administration for the treatment of calcium deficiency and kidney diseases, may increase the likelihood of surviving ovarian cancer. This new study opens a potential avenue for treating ovarian cancer. Since Calcit...

06/13/2018

https://www.technologynetworks.com/neuroscience/news/mechanism-by-which-alpha-synuclein-causes-cell-death-in-parkinsons-identified-305013?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63721315&_hsenc=p2ANqtz-9U5Q93Dnyt8A9uxfFDcZYrT_JbKGKnNOLHzBDxRLCO69JZfAu9isQtfByB6ISrfDuV5khwAjIIqMkBTmU1kCXq96D1tw&_hsmi=63721315

Detailed brain cell analysis has helped researchers uncover new mechanisms thought to underlie Parkinson's disease.

06/11/2018

https://www.technologynetworks.com/cancer-research/news/study-identifies-cellular-death-code-304908?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63648751&_hsenc=p2ANqtz-8zBrSCAF0J16KmurOwLt9FkBIFyGQYXc_ZBiqIpesjYfkHXlWpGoxFxSTJ8ED6f9KjdC0vXPMc6YjU8KoLQ2uK2VHVaA&_hsmi=63648751

Dying cells generally have two options: go quietly, or go out with a bang. The latter, while more conspicuous, is also mechanistically more mysterious. Now, scientists have pinpointed what they believe is the molecular

06/07/2018

https://www.technologynetworks.com/cancer-research/news/telomerase-highest-level-of-detail-ever-seen-304781?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63575853&_hsenc=p2ANqtz-9f5bQ9qR441-ncJf_JPhBq2iLT3QhFwjdm9hBJElL7Cqg7lAB_dKmsCnW_MsTTDij8I2YBi3a-OfTtITHMqRiHT4_NIw&_hsmi=63575853

Researchers report the deepest scientific understanding yet of this once-mysterious enzyme, whose catalytic core -- where most of its activity occurs -- can now be seen in near atomic resolution. Telomerase is especially active in cancer cells, which enables cancer to grow and spread.

06/05/2018

https://www.technologynetworks.com/biopharma/news/antibody-shrinks-tumors-of-patients-with-advanced-skin-cancer-304710?utm_campaign=Newsletter_TN_BreakingScienceNews&utm_source=hs_email&utm_medium=email&utm_content=63500679&_hsenc=p2ANqtz--ATAIe0GBID_cq1IA8DRsi53ULrbo5xgWyF5bb1G7z4tscabYQ3D3fwK8t-Q6NNIY-RjugawkQQqUq81JTd9Bz-vaSwQ&_hsmi=63500679

Clinical trials show that an immune checkpoint inhibitor shrinks the tumors of nearly half of patients with an incurable, advanced form of a common skin cancer.

05/30/2018

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117380/

Ultraviolet light is an established carcinogen yet evidence suggests that UV-seeking behavior has addictive features. Following UV exposure, epidermal keratinocytes synthesize Proopiomelanocortin that is processed to Melanocyte Stimulating Hormone, inducing ...

05/30/2018

https://journals.lww.com/eurjcancerprev/Abstract/2018/03000/Coffee_consumption_and_risk_of_nonmelanoma_skin.10.aspx

ffee intake and the risk of nonmelanoma skin cancer. Studies were identified by searching the PubMed and MEDLINE databases (to November 2015). Study-specific risk estimates were pooled under the random-effects model. We separately estimated the relative risk of the three conditions, for exposure to....

05/29/2018

www.pnas.org/content/111/16/5773.long

The long-held but erroneous assumption of never-ending rapid growth in biomedical science has created an unsustainable hypercompetitive system that is discouraging even the most outstanding prospective students from entering our profession—and making it difficult for seasoned investigators to prod...