10/25/2025
Rhythmic Hormone Dosing: Unlocking True Menopausal Relief
For women experiencing vasomotor symptoms, genitourinary changes, or bone loss, the timing and pattern of hormone delivery matters as much as the dose (Santoro, 2020; Stuenkel, 2015).
Key Advantages of Rhythmic Dosing:
Mimics natural estradiol and progesterone cycles, optimizing receptor priming and genomic signaling.
Supports bone density, cardiovascular health, and cognitive function more effectively than static dosing (Hodis & Mack, 2018).
Improves sleep, mood, and sexual well-being by restoring neurosteroid activity (Stanczyk, 2019).
Can safely use lowest effective doses with transdermal or oral administration.
Women without a uterus may safely receive unopposed estrogen; progestogens are unnecessary (NAMS, 2023).
Even for women over 60 or >10 years post-menopause, individualized rhythmic hormone therapy can be considered when benefits outweigh risks—offering symptom relief and systemic protection.
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