02/17/2026
If your estradiol injections are itching, knotting up, or hurting… you’re not alone 👀
Weekly SQ estradiol cypionate (in MCT oil) can still cause irritation — not because it’s “bad,” but because oil + fatty tissue can pool and inflame.
Here’s how to make it WAY more comfortable 👇
✨ Warm the vial + syringe first
Cold oil = thicker oil = more irritation
✨ Inject slooooow
Think 45–90 seconds. Let the tissue relax instead of forcing it.
✨ Split your dose
Instead of one weekly shot → split into 2 smaller injections.
Smaller volume = fewer knots 🙌
✨ Rotate sites
Flanks or upper outer glute fat tend to react better than the belly for thicker oils.
✨ Massage + heat after
This helps the oil disperse instead of sitting in a painful lump.
🚩 If you’re getting redness that spreads, severe pain, or knots lasting weeks — check in with your provider.
Your hormones aren’t “wrong.”
Your body just wants a gentler approach. 💛
