Lifespan Research Institute

11/03/2025

Every dollar now counts twice, thanks to a $25,000 match from the LRI Board!

The Public Longevity Group (PLG) campaign has passed the halfway mark toward its goal. To help us finish strong, LRI board members will match every dollar through the final stretch.

Your support powers the first public sentiment analysis system for longevity science, built to measure and strengthen the impact of advocacy efforts across the field.

Public trust is the breakthrough that unlocks all others.

�Now is the time to make twice the impact:

Building the first public sentiment analysis engine to unlock public trust in longevity.

10/29/2025

Milestone reached! The Public Longevity group campaign has officially passed the 50% mark. Huge thanks to everyone who has supported so far. Onwards to the finish line!

Learn more & support here:
https://www.lifespan.io/campaigns/public-longevity-group/

10/28/2025

Final week to apply! Hosting a student through the LRI Education Program means gaining skilled, motivated help in your lab while making a real impact on the next generation of longevity researchers.

Since 2013, we’ve matched nearly 200 students with labs working to tackle the root causes of aging. Join our network of mentors shaping the future of longevity science!

Learn more and apply:
https://ow.ly/bVS050XiVyf

10/22/2025

Thank you to the ALSAE Foundation for supporting the launch of the Public Longevity Group!

Founded by Maria Entraigues and Gary J. Alan, ALSAE fosters thoughtful exploration of longevity science by engaging artists, entertainers, and storytellers to move beyond outdated tropes, illuminating the real impact and possibilities of curing the chronic diseases of aging.

Learn more about the PLG Campaign:
https://www.lifespan.io/campaigns/public-longevity-group/

Learn more about ALSAE:
https://alsae.org/

10/20/2025

LRI’s Sharma Lab has published new findings in Aging Cell on Urolithin A (UA) as a senomorphic approach to combating age-related inflammation.

The team shows that UA, a gut-derived metabolite, reduces pro-inflammatory SASP and DAMP signaling in senescent fibroblasts by limiting cytosolic DNA leakage and dampening cGAS–STING activation.

Unlike senolytics, UA doesn’t eliminate senescent cells; instead, it suppresses paracrine senescence and inflammatory signaling, revealing a new therapeutic approach for mitigating inflammaging and age-related diseases.

Read the full paper here:

Senescent cells accumulate extranuclear DNA fragments that are recognized by the cyclic GMP-AMP synthase (cGAS) and its effector protein stimulator of interferon genes (STING), which promotes express...

10/16/2025

Check out the latest Sheekey Science Show episode, where Eleanor Sheekey chats with Sho Ozaki Tan., founder of the Public Longevity Group (PLG), about how cultural perception shapes the future of longevity science and what it will take to shift the narrative.

Learn more and support PLG here👇
https://www.lifespan.io/campaigns/public-longevity-group/

Full Sheekey Science Show Episode👇
https://www.youtube.com/watch?v=bnUPDSe-YXI

In this episode, I speak with Sho Joseph Ozaki Tan, founder of the Public Longevity Group (PLG), about an often overlooked challenge in longevity research: p...

10/15/2025

Big thanks to the Academy for Health & Lifespan Research, the newest member of our Lifespan Alliance, for supporting our Public Longevity Group initiative.

Their contribution is helping us launch the first public sentiment analysis engine for longevity science, building the cultural foundation for longer, healthier lives.

Join us in shaping the future of medicine:
https://www.lifespan.io/campaigns/public-longevity-group/

10/08/2025

Big thanks to Immortal Dragons for backing our Public Longevity Group initiative!

Help us keep the momentum going👇
https://lnkd.in/dxC_RwvW

More about Immortal Dragons:
https://www.id.life

10/07/2025

To challenge cultural stereotypes and misconceptions about longevity, a new organization aims to engage people who create culture. Its list of “cultural ambassadors” includes Oscar- and […]

10/06/2025

Join the conversation with Keith Comito and LRI's Longevity Investor Network at Longevity Biotech 2025.

With over 100 decision makers from biotech, pharma, VC companies, and academia already registered to attend, this is a final call to join the global longevity therapeutics community in Boston, October 22-23.

Hear from key opinion leaders such as Andrea Meier, Paul Ridder, Adam Antebi, institutional investors like LongeVC, LongevityTech.fund, Maximon - The Longevity Company Builder and leading biotechs including the likes of Life Biosciences, BioAge Labs and BioVie Inc..

Register Here:
https://preview.mailerlite.io/preview/1663649/emails/166873944936154124

10/01/2025

Today is Longevity Day, a global reminder that extending healthy human lifespan is one of the defining challenges of our time.

At Lifespan Research Institute, we’re advancing bold research programs that target the root causes of aging, while also building the systems and trust needed to ensure breakthroughs benefit everyone.

Our Longevity Investor Network links capital to high-impact projects, moving discoveries closer to therapies. And through Lifespan News, we bring the latest advances in longevity science to the world, bridging researchers and the public.

This year, with the launch of the Public Longevity Group (PLG), we’re tackling the missing link: building public understanding and support for longevity science. Because the breakthrough that unlocks all others is cultural legitimacy.

On Longevity Day, join us in imagining, and building, a future where longer, healthier lives are possible for all.

Support LRI:
https://www.lifespan.io/how-you-can-help/

Support the PLG Crowdfunding Campaign:
https://www.lifespan.io/campaigns/public-longevity-group/

09/26/2025

First milestone reached!

Our Public Longevity Group campaign has just passed 30% of our goal, thanks to a generous $25k donation from AgingBiotech.info and Karl Pfleger.

Rigorously quantifying public perception of longevity research is a vital catalyst for advancing the work of our entire field, and support like this is what makes it possible.

Learn more and add your support here:
https://www.lifespan.io/campaigns/public-longevity-group/