09/17/2025
What are some arthritic conditions that are genetic?
The root words for ‘arthritis’ simply mean ‘inflammation of a joint.’
Osteoarthritis is not caused by genetics, but is a product of certain lifestyle factors, such as:
- lack of adequate hydration
- poor diet
- lack of physical activity
- sedentarism
However there are inflammatory arthritic conditions that are strongly linked to certain biomarkers or genes.
Many of us have heard of rheumatoid arthritis, and perhaps you know someone who has tested positive for rheumatoid factor and deals with pain on a regular basis.
What could explain the arthritis though once all mechanical factors are addressed, and a person tests negative for rheumatoid?
There are four non-serologic inflammatory conditions that cause joint deterioration, namely:
- ankylosing spondylitis
- enteropathic arthritis
- reactive arthritis
- psoriatic arthritis
All of which are linked to the HLA-B27 gene, which raises your risk of developing these.
Certain environmental factors can trigger these conditions simply because genetics makes the person susceptible to them.
These are autoimmune conditions, so infections or diseases can trigger these. Other factors include gut-health.
Having a healthy gut biome reduces inflammation in the bowel, which has been shown to increase inflammation throughout the entire body.
Not only does gut inflammation contribute to osteoarthritis, but it can instigate even more serious proinflammatory conditions.
If you’ve been told that you have IBS, that is wholeheartedly a condition that you can correct. It’s not symptom to shrug off like a sniffle in the winter time.
It affects your entire body all of the time! Identifying and eliminating food triggers like nightshades, dairy, or gluten from your diet could not only change your life but it could protect your joints for a lifetime!
Enteropathic arthritis is strongly linked to irritable bowel disorders like ulcerative colitis and Crohn’s disease, and on imaging looks nearly identical to ankylosing spondylitis.
If you have pain that is flared-up at the drop of a hat and does not get better within 4-6 weeks of routine treatment, take a look at your diet!