ICARE - Inherited Cancer Registry

ICARE - Inherited Cancer Registry ICARE is a research study that aims to establish a registry of individuals interested in participating in inherited cancer research studies

ICARE is a questionnaire-based research study established in June 2010, representing a clinical-research-community partnership among medical practitioners, researchers, and members of the general population.Through ICARE, we hope to improve access to cancer genetics expertise for patients and healthcare providers. The common goal of our efforts is to improve the lives of patients and families at risk for inherited cancer susceptibility. This involves performing research in all aspects of familial cancer spanning from prevention and detection to treatment. There is no cost to participate in ICARE and communications can be conducted via phone, email, or mail. If inherited cancer has affected you or a family member, we encourage you to explore our website where you can learn more about ICARE and the services we offer, as well as join our registry.

02/11/2026

Why have genetic testing?

Genetic testing for inherited cancer can help guide care, including:
• Cancer treatment plans, such as chemotherapy, drugs, surgery, and radiation
• Cancer screening and prevention

Sharing genetic test results can also help family members understand their cancer risks.

A new study evaluated breast cancer risks in RAD51C carriers based on family history and found that risks for breast can...
02/11/2026

A new study evaluated breast cancer risks in RAD51C carriers based on family history and found that risks for breast cancer were higher in those with a family history, but only at later stages. Additional non-genetic risk factors were also important modifiers of risk.

To learn more read the article at: https://f.mtr.cool/jmxwqoijmb

Reference: O'Brien, et al. JAMA Oncol. 2025. Online ahead of print. PMID: 41066089.

A mutation in MLH1 can increase the risk for certain cancers. Early screening and regular checkups are key to staying ah...
02/10/2026

A mutation in MLH1 can increase the risk for certain cancers. Early screening and regular checkups are key to staying ahead. To learn more, check out the full National Comprehensive Cancer Network (NCCN) guidelines by creating a FREE account at:
https://f.mtr.cool/qlflfupzqo
https://f.mtr.cool/nwodgvmipv

If you tested positive for MLH1, we’d love to hear from you in the comments – we know that information and guidelines are changing quickly. How do you keep up?

If you aren’t already enrolled in ICARE, visit https://f.mtr.cool/jtjuemtegg to enroll and receive care updates as new guidelines come out.

EVERY HAND HELPS.When you join ICARE, you’re helping researchers end the cycle of inherited cancer. Let’s work together ...
02/09/2026

EVERY HAND HELPS.
When you join ICARE, you’re helping researchers end the cycle of inherited cancer. Let’s work together for a healthier tomorrow. Enroll today at: https://redcap.link/ICAREconsent

02/07/2026

Did you know that inherited cancer gene mutations in TP53, RB1, NF1, APC, KIT, and PDGFR can raise the risk for certain sarcomas? In fact, one in ten people with osteosarcoma have an inherited cancer risk gene mutation. If you are a sarcoma patient, you may want to consider genetic testing.

We ask that you also consider joining our CAUSAL study through which we trying to learn more about sarcoma patients. No travel to our center is needed, and everything can be done online. Participating in this study involves taking surveys, monitoring your physical activity with a free Fitbit, free genetic testing for inherited cancer, and free tumor testing. Your participation could help develop new ways to improve cancer treatment and quality of life as well as to learn more about sarcoma causes and prevention.

To learn more, visit https://tinyurl.com/CAUSALstudy

A mutation in MSH2 can increase the risk for certain cancers. Early screening and regular checkups are key to staying ah...
02/06/2026

A mutation in MSH2 can increase the risk for certain cancers. Early screening and regular checkups are key to staying ahead. To learn more, check out the full National Comprehensive Cancer Network (NCCN) guidelines by creating a FREE account at:
https://f.mtr.cool/zlefamlceu
https://f.mtr.cool/vgevnbuybq

If you tested positive for MSH2, we’d love to hear from you in the comments – we know that information and guidelines are changing quickly. How do you keep up?

If you aren’t already enrolled in ICARE, visit https://f.mtr.cool/lwcygdkink to enroll and receive care updates as new guidelines come out.

Inherited Cancer Misconception vs. Reality ⤵Misconception: Inherited cancer testing is only for breast or ovarian cancer...
02/06/2026

Inherited Cancer Misconception vs. Reality ⤵

Misconception: Inherited cancer testing is only for breast or ovarian cancer.

Reality: Inherited mutations are linked to many cancers — including colorectal, prostate, pancreatic, melanoma, and uterine cancers, among others.

Register now for Take Charge of Your Cancer Risk: Learn What Your Genes Can Tell You, an interactive webinar co-hosted b...
02/06/2026

Register now for Take Charge of Your Cancer Risk: Learn What Your Genes Can Tell You, an interactive webinar co-hosted by The Insighters and Susan G. Komen on February 25th, 2026 at 2pm ET.

We're thrilled that ICARE Principal Investigator and Clinical Geneticist, Dr. Tuya Pal, will be one of the featured speakers to share insights on genetic testing for inherited cancer and strategies to reduce cancer risks.

Register now at: https://tinyurl.com/TakeChargeWebinar

Why is funding for science so important?• Money for research is used to find new cures for cancer• Research today allows...
02/05/2026

Why is funding for science so important?
• Money for research is used to find new cures for cancer
• Research today allows for cures for tomorrow
• Less research done will lead to more deaths from cancer

Remember, funding science will lead to better ways to find, prevent, and treat cancer. Share this post so we, the people, can spread the word about why cancer research is important!

Learn more by reading the full article at: https://f.mtr.cool/mrbjewmhkeReference: Dai et al. JAMA Oncol. 2025:e252681. ...
02/05/2026

Learn more by reading the full article at: https://f.mtr.cool/mrbjewmhke

Reference: Dai et al. JAMA Oncol. 2025:e252681. PMID: 40839273.

Did you know that by participating in ICARE you may be able to contribute to other research efforts?For example, ICARE h...
02/05/2026

Did you know that by participating in ICARE you may be able to contribute to other research efforts?

For example, ICARE helps facilitate:
• Genomic studies on tumor samples to better understand tumor development
• Other focused research efforts to help figure out cancer risks and improve outcomes in cancer patients

To learn more about participating in ICARE or if you'd like to enroll online, visit https://redcap.link/ICAREconsent

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ICARE is a questionnaire-based research study established in June 2010, representing a clinical-research-community partnership among medical practitioners, researchers, and members of the general population. Through ICARE, we hope to improve access to cancer genetics expertise for patients and healthcare providers. The common goal of our efforts is to improve the lives of patients and families at risk for inherited cancer susceptibility. This involves performing research in all aspects of familial cancer spanning from prevention and detection to treatment. There is no cost to participate in ICARE and communications can be conducted via phone, email, or mail. If inherited cancer has affected you or a family member, we encourage you to explore our website where you can learn more about ICARE and the services we offer, as well as join our registry.