12/02/2025
Research has found the same bacteria that cause gum disease, especially Porphyromonas gingivalis, in the brains of people with Alzheimer’s. These bacteria release toxic enzymes called gingipains, which are known to damage brain cells.
Periodontitis is not only a gum problem — it is an inflammatory condition. When these bacteria enter the bloodstream, they may reach the brain and activate immune cells there. This leads to inflammation, a key feature seen in Alzheimer’s disease.
Bacterial toxins from the mouth can interfere with how brain cells communicate. They may increase amyloid-beta buildup, harm neurons, and speed up memory loss in experimental studies.
Research does not prove that gum disease causes Alzheimer’s, but it shows a strong biological connection. Oral bacteria, inflammation, and brain changes appear to be linked in ways scientists continue to explore.