10/16/2025
We’re excited to share a new way of understanding benzodiazepine withdrawal — through biology, not dose alone.
For years, tapering has focused on how small a cut to make or how slow to go. But real-world experiences show that symptoms vary widely — not just by dose, but by underlying brain and immune pathways.
Our newly released research on medRxiv introduces a Five-Axis Mechanistic Framework that maps withdrawal into biologically distinct patterns:
🧠 CRH-heavy (stress-adrenergic)
⚡ Excitatory–Neuroinflammatory
💓 Autonomic
🧩 BG/Cerebellar
🌸 MCAS-overlap (immune/allergic modifier)
This model reframes tapering as a process of stabilizing systems — not just reducing medication.
It’s a new paradigm for safer, more predictable recovery.
🔗 Explore the full framework on our website: www.thebenzotaperdoctor.com
📖 Read the full paper: https://www.medrxiv.org/content/10.1101/2025.10.07.25336923v1
