12/28/2025
Corticosteroids 💊
Corticosteroids are anti-inflammatory and immunosuppressive drugs that are widely used to treat many medical conditions by reducing inflammation and suppressing the immune response.
🔬 What are Corticosteroids?
They are synthetic drugs similar to cortisol, a hormone naturally produced by the adrenal glands.
⚙️ Mechanism of Action
Suppress inflammatory mediators (prostaglandins, cytokines)
Reduce capillary permeability → less swelling
Suppress immune system activity
Decrease allergic and autoimmune responses
🧾 Common Examples
Prednisolone
Prednisone
Hydrocortisone
Dexamethasone
Methylprednisolone
Betamethasone
🩺 Uses / Indications
Inflammatory diseases (asthma, arthritis, IBD)
Autoimmune disorders (SLE, rheumatoid arthritis)
Allergic reactions
Shock and adrenal insufficiency
Brain edema
Organ transplant (to prevent rejection)
Certain cancers
💉 Routes of Administration
Oral (tablets/syrup)
IV / IM injections
Inhalation (asthma)
Topical (creams, ointments)
Intra-articular (joint injections)
⚠️ Side Effects (Long-term Use)
Weight gain & moon face
Hypertension
Hyperglycemia (diabetes)
Osteoporosis
Increased risk of infections
Gastric ulcers
Adrenal suppression
🚫 Important Nursing / Patient Points
Never stop abruptly → taper gradually
Take with food to reduce gastric irritation
Monitor BP, blood sugar, weight
Watch for signs of infection
Use lowest effective dose
📌 Key Point
Corticosteroids are very effective but powerful drugs—beneficial when used correctly, harmful if misused.
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