07/06/2023
POTS? What is it
DEFINITION AND MANIFESTATIONS OF POTS
Postural Orthostatic Tachycardia Syndrome
POTS is a chronic syndrome defined by a sustained increase in heart rate of at least 30 beats per minute (bpm) within 10 minutes of standing in adults (or ≥ 40 bpm in patients ages 12 to 19) without accompanying orthostatic hypotension, which is defined as a fall in systolic blood pressure of 20 mm Hg or greater or a fall in diastolic blood pressure of 10 mm Hg or greater.
The onset is typically often follows a trigger such as infection, surgery, trauma, or childbirth. Heat, fever, dehydration, morning hours, strong emotion, and menstruation have been known to exacerbate symptoms. The typical age at onset is between 15 and 45, and at least 80% of patients are women.
A typical presentation of POTS is in a young active woman with a subacute onset of lightheadedness, dizziness, provoked by standing, often following a viral illness, surgical procedure, trauma, or prolonged period of inactivity. The patient may report that symptoms are worse in warm weather or morning hours, or when feeling particularly stressed or anxious.
The diagnostic evaluation of POTS starts with a focused history centering on symptom onset and progression,other medical conditions, precipitating and exacerbating factors. Other topics and investigations include the following:
Diet, including meal size and frequency and the volume of salt and water intake, is important in looking for symptom triggers and developing treatment strategies. Reducing the size of meals reduces the likelihood of postprandial hypotension, with less blood flow routed away from the brain to the gastrointestinal system.
Exercise tolerance (length and type of exercise) can be used to assess the severity of symptoms and evaluate treatment efficacy over time.
Medications with side effects that mimic POTS symptoms include diuretics, vasodilators, antipsychotics, anticholinergics, nonstimulant medications for attention deficit hyperactivity disorder (eg, atomoxetine), and oral contraceptive pills with antimineralocorticoid action (eg, those that contain drospirenone)
The physical examination should include a complete cardiac and neurologic assessment. Look for clues pointing to diseases that can produce a POTS-like phenotype, such as:
Thyroid dysfunction (exophthalmos, goiter, hair-thinning, nail discoloration)
Anemia (pallor, jaundice, cool or discolored extremities)
Connective tissue disorders such as Ehlers-Danlos syndrome (joint hypermobility).
Treatments:
Once the diagnosis of POTS is established, initial treatment is aimed at reducing symptoms, improving quality of life, and educating the patient. Nonpharmacologic strategies should be the first intervention and include the following:
Volume expansion by increasing oral intake of water to 2 to 3 L/day and salt to 10 to 12 g/day (regular intravenous fluid infusions are not recommended and are potentially harmful
Compression garments including abdominal and thigh compression and full abdominal and leg compression
Sleeping with the head of the bed elevated 4 to 6 inches
Removing exacerbating factors such as large meals and medications
A graded exercise program featuring endurance reconditioning and lower-body resistance training can be highly beneficial
Behavioral and cognitive therapy should also be considered for patients with significant anxiety, somatic hypervigilance, or catastrophizing behaviors.
TAKE-HOME POINTS
Although the etiology and pathophysiologic mechanisms underlying POTS remain uncertain, a clinical diagnosis can be made with a focused history, examination, and basic diagnostic evaluation.
Initial treatment strategies are simple and include optimizing fluid intake, compression stockings, avoiding known triggers, exercise to improve stamina, and cognitive behavioral therapy to reduce hypervigilance.