Lexi Yoo, FNP, IFMCP, 9535 E 151th Street, Noblesville, IN (2026)

02/07/2026

𝗧𝗵𝗲 𝗽𝗿𝗼𝗯𝗹𝗲𝗺 𝗻𝗼 𝗼𝗻𝗲 𝗽𝗿𝗲𝗽𝗮𝗿𝗲𝘀 𝗽𝗮𝘁𝗶𝗲𝗻𝘁𝘀 𝗳𝗼𝗿 𝘄𝗶𝘁𝗵 𝗚𝗟𝗣-𝟭𝘀
💉Many people start a GLP-1 medication and feel like something finally clicks.
Hunger quiets. Food noise fades. Weight drops. Blood sugar stabilizes. 🍽️

The same behaviors that once felt impossible suddenly feel manageable.

📆Then ➡️ months later➡️ something shifts.

🍭 Appetite creeps back. Weight loss slows or stalls. The same dose feels ineffective!
👉🏻 Patients assume they did something wrong. Clinicians often escalate the dose.

🔑 But this isn’t a failure of willpower or compliance.
It’s a predictable biological response. 🧬

👉🏻GLP-1 receptor agonists work by temporarily shifting appetite signaling, gastric emptying, and energy balance. While they’re on board, they blunt the body’s natural defense against weight loss.

𝗕𝘂𝘁 𝗵𝘂𝗺𝗮𝗻 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗽𝗮𝘀𝘀𝗶𝘃𝗲𝗹𝘆 𝗮𝗰𝗰𝗲𝗽𝘁 𝘄𝗲𝗶𝗴𝗵𝘁 𝗹𝗼𝘀𝘀. 𝗔𝘀 𝘄𝗲𝗶𝗴𝗵𝘁 𝗱𝗿𝗼𝗽𝘀:
• Hunger signals rise
• Satiety signals fall
• The brain becomes more sensitive to food cues
• Energy expenditure subtly declines

👉🏻Over time, the nervous system adapts. The signal-to-noise ratio changes.
The medication may still be improving glucose, lipids, and cardiometabolic risk 👇🏻 even as weight loss slows.

𝗣𝗹𝗮𝘁𝗲𝗮𝘂 𝗶𝘀 𝗻𝗼𝘁 𝗳𝗮𝗶𝗹𝘂𝗿𝗲.
Adaptation is not the drug “stopping.”

📚Longevity-focused care requires acknowledging this biology not ignoring it.

💬 Comment “GLP1” to get my latest Substack where I break down the research and what this means for long-term metabolic strategy.

02/06/2026

🦋𝗔𝘂𝘁𝗼𝗶𝗺𝗺𝘂𝗻𝗶𝘁𝘆 𝗱𝗼𝗲𝘀𝗻’𝘁 𝗵𝗮𝗽𝗽𝗲𝗻 𝗼𝘃𝗲𝗿𝗻𝗶𝗴𝗵𝘁 𝗮𝗻𝗱 𝗶𝘁 𝗿𝗮𝗿𝗲𝗹𝘆 𝗵𝗮𝘀 𝗷𝘂𝘀𝘁 𝗼𝗻𝗲 𝗰𝗮𝘂𝘀𝗲.
👉🏻But have you ever wondered why autoimmune conditions affect women far more often than men… and why symptoms so often appear or worsen during perimenopause?

𝘛𝘩𝘪𝘴 𝘪𝘴𝘯’𝘵 𝘢 𝘤𝘰𝘪𝘯𝘤𝘪𝘥𝘦𝘯𝘤𝘦 𝘢𝘯𝘥 𝘪𝘵’𝘴 𝘯𝘰𝘵 “𝘫𝘶𝘴𝘵 𝘩𝘰𝘳𝘮𝘰𝘯𝘦𝘴.”

🎀 Women carry a uniquely sensitive immune system. Estrogen plays a powerful role in immune signaling, inflammation, and gut integrity. During the reproductive years, it can be protective. But in perimenopause, fluctuating estrogen and progesterone can create immune instability especially if the system was already under strain.

🔺𝗡𝗼𝘄 𝗹𝗮𝘆𝗲𝗿 𝗶𝗻 𝘁𝗵𝗲 𝗙𝗮𝘀𝗮𝗻𝗼 𝗧𝗿𝗶𝗮𝗱:🔺

🧬 𝗚𝗲𝗻𝗲𝘁𝗶𝗰𝘀 & 𝗲𝗽𝗶𝗴𝗲𝗻𝗲𝘁𝗶𝗰𝘀 : many women carry autoimmune-predisposing genes, but expression depends on timing and stressors.
🦠 𝗚𝘂𝘁 𝗵𝗲𝗮𝗹𝘁𝗵 – hormonal shifts can increase intestinal permeability, alter the microbiome, and amplify immune reactivity.
🌎 𝗘𝗻𝘃𝗶𝗿𝗼𝗻𝗺𝗲𝗻𝘁 – chronic stress, nutrient depletion, infections, toxins, and years of over-giving often peak by midlife.

When these factors intersect, immune tolerance can breaknoften showing up as fatigue, joint pain, thyroid issues, skin flares, or “mystery” symptoms women are told are normal.

✨ This is why healing isn’t about suppressing symptoms.
✨ It’s about stabilizing hormones, restoring gut integrity, and reducing immune triggers so the body can regulate again.

👉🏻What if your autoimmune symptoms are your body asking for support during a major biological transition not signaling failure?

📚 𝗜𝗳 𝘆𝗼𝘂 𝘄𝗮𝗻𝘁 𝘁𝗼 𝗴𝗼 𝗱𝗲𝗲𝗽𝗲𝗿, 𝗰𝗼𝗺𝗺𝗲𝗻𝘁 “𝗔𝗨𝗧𝗢𝗜𝗠𝗠𝗨𝗡𝗘” 𝘁𝗼 𝗿𝗲𝗮𝗱 𝗺𝘆 𝗹𝗮𝘁𝗲𝘀𝘁 𝗦𝘂𝗯𝘀𝘁𝗮𝗰𝗸 𝗮𝗿𝘁𝗶𝗰𝗹𝗲.

📌Save & share if this helped you understand why autoimmunity so often emerges in women during perimenopause.

02/06/2026

Your body cannot repair itself while it’s in survival mode.
That’s not mindset… that’s physiology. 🧠

When the nervous system is stuck in fight or flight, the body prioritizes protection over healing:
• Blood flow is diverted away from tissues 🩸
• Inflammation stays elevated 🔥
• Hormones stop signaling efficiently 🧬
• Pain pathways stay activated ⚡

This is why some patients do everything right 👉🏼labs, supplements, hormones, lifestyle and still don’t improve.

🧘🏻‍♀️Healing requires a parasympathetic state.
Rest. Repair. Regulation.

💉Neural therapy is one way I help the nervous system step out of chronic defense and back into balance. It works by addressing autonomic dysregulation at the level where stress, trauma, illness, and inflammation get “stuck” in the body.

🫶🏻Especially in perimenopause, I see this pattern constantly:
Symptoms escalate not because the body is broken but because it doesn’t feel safe enough to heal.

🧠Calm is not a personality trait.
It’s a biological prerequisite. 🧘‍♀️

If this helped you understand your symptoms:
➡️ Save this
➡️ Share it with someone who feels stuck
➡️ Follow for more education

02/05/2026

𝗜𝗳 𝘆𝗼𝘂’𝘃𝗲 𝗯𝗲𝗲𝗻 𝘁𝗼𝗹𝗱 “𝗶𝘁’𝘀 𝗷𝘂𝘀𝘁 𝗵𝗼𝘁 𝗳𝗹𝗮𝘀𝗵𝗲𝘀,”
𝘆𝗼𝘂’𝗿𝗲 𝗻𝗼𝘁 𝗴𝗲𝘁𝘁𝗶𝗻𝗴 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗽𝗶𝗰𝘁𝘂𝗿𝗲.

Perimenopause is a full-body transition, not a single symptom.
Hormone fluctuations can affect your brain, gut, nervous system, metabolism, skin, joints, and mood all at the same time.

👉🏻Fatigue.
👉🏻Mood swings.
👉🏻Brain fog.
👉🏻Joint pain.
👉🏻Digestive changes.
👉🏻Heart palpitations.
👉🏻New food sensitivities.
👉🏻Dry or itchy skin.
👉🏻Hair thinning.

These are hormone signals, not random issues.

✨ Perimenopause is not a disease.
✨ You’re not “crazy.”
✨ You’re not “too young.”

𝗬𝗼𝘂𝗿 𝗯𝗼𝗱𝘆 𝗶𝘀 𝗰𝗼𝗺𝗺𝘂𝗻𝗶𝗰𝗮𝘁𝗶𝗻𝗴 𝗮𝗻𝗱 𝗶𝘁 𝗱𝗲𝘀𝗲𝗿𝘃𝗲𝘀 𝘀𝘂𝗽𝗽𝗼𝗿𝘁, 𝗻𝗼𝘁 𝗱𝗶𝘀𝗺𝗶𝘀𝘀𝗮𝗹.

Save this if it resonates.
Share it with someone who needs to hear this. 💗

02/05/2026

𝗣𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗶𝘀 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗵𝗼𝗿𝗺𝗼𝗻𝗲 𝘁𝗼 𝗱𝗲𝗰𝗹𝗶𝗻𝗲 𝗶𝗻 𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗼𝗳𝘁𝗲𝗻 𝘆𝗲𝗮𝗿𝘀 𝗯𝗲𝗳𝗼𝗿𝗲 𝗲𝘀𝘁𝗿𝗼𝗴𝗲𝗻 𝘀𝘁𝗮𝗿𝘁𝘀 𝘁𝗼 𝗳𝗮𝗹𝗹.

As a Functional med NP, I see women struggling not from lack of estrogen, but from unrecognized progesterone deficiency.

🧠 Low progesterone impacts sleep, mood, and nervous system regulation
📉 You can have “normal” periods and estrogen labs and still not be ovulating
💤 Mid-cycle insomnia, anxiety, and heavy periods are early red flags

This is why giving estrogen without supporting 𝗽𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗰𝗮𝗻 𝗯𝗮𝗰𝗸𝗳𝗶𝗿𝗲 𝗺𝗮𝗸𝗶𝗻𝗴 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀 𝘄𝗼𝗿𝘀𝗲, 𝗻𝗼𝘁 𝗯𝗲𝘁𝘁𝗲𝗿.

💊 Bioidentical oral progesterone (often 100–200 mg nightly) is especially helpful for sleep and anxiety
📈 Labs matter, but symptoms tell the full story
🧪 A progesterone-to-estrogen ratio is more informative than a single value

The goal isn’t just “normal labs.” It’s hormonal balance, symptom relief, and protecting long-term health especially the brain, sleep, and uterus.

➡️ Follow for clinical hormone education rooted in physiology
💾 Save or share if this helped you connect the dots

🧘🏻‍♀️How did you feel after you started taking progesterone? Any improvements in mood?

02/05/2026

👉🏼GLP-1s can be powerful tools when they’re used correctly.
Most problems I see in clinic aren’t from the medication itself… they’re from how it’s used.

🚫 What I don’t recommend while taking GLP-1s:
• Treating it like a crash diet
• Eating too little protein
• Skipping resistance training
• Ignoring fatigue, hair loss, or weakness
• Chasing the scale while losing muscle
Using NAD because the Sema has you tired!

🧠 GLP-1s improve satiety and insulin signaling they are not meant to override basic physiology. When women under-fuel, especially in perimenopause, the body adapts by slowing metabolism, losing muscle, and stressing hormones.

💪 Muscle is not optional in midlife.
It protects metabolic rate, bone density, insulin sensitivity, and long-term independence. Weight loss without muscle preservation is not health optimization.

📉 Feeling awful on a GLP-1 is not a personal failure, it’s usually a signaling problem that hasn’t been addressed.

📚 I break this down more deeply on The Better Yoo Project and in longer writing on my Substack for those who want the full physiology.

👉 Follow for evidence-based hormone and metabolic education

02/05/2026

♥️𝗔𝗱𝗱𝘆𝗶 𝘄𝗼𝗿𝗸𝘀 𝗯𝗲𝘀𝘁 𝘄𝗵𝗲𝗻 𝘄𝗲 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱 𝘄𝗵𝗮𝘁 𝗶𝘁’𝘀 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝘁𝗼 𝗱𝗼.

🧠 Addyi acts in the brain, not the pelvis. It gently shifts neurotransmitters by lowering serotonin and increasing dopamine and norepinephrine, with the goal of restoring baseline sexual interest over time. It’s not designed for instant arousal or “on-demand” effects, and it doesn’t need to be to have value.

✨ Where Addyi can be helpful is a very specific pattern of low desire: generalized, acquired loss of interest that isn’t primarily driven by pain, tissue changes, or hormone deficiency.

💡 When Addyi isn’t the right fit, that’s not a failure... it’s information. Libido has multiple drivers, and each requires a different approach. Neurochemistry is one piece of a much larger picture.

👉🏻Precision matters. Context matters. And women deserve sexual health care that reflects that complexity.

👉 Follow for continued clinical education on women’s sexual health, hormones, and peptides.
🔁 Share with someone who’s been curious but unsure.

02/04/2026

𝗢𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗰𝗼𝗺𝗺𝗼𝗻 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀 𝗜 𝗵𝗲𝗮𝗿 𝗶𝘀: “𝗗𝗼 𝗜 𝗻𝗲𝗲𝗱 𝗹𝗲𝘀𝘀 𝗲𝘀𝘁𝗿𝗼𝗴𝗲𝗻 𝗼𝗿 𝗶𝘀 𝗺𝘆 𝗯𝗼𝗱𝘆 𝗷𝘂𝘀𝘁 𝗻𝗼𝘁 𝗵𝗮𝗻𝗱𝗹𝗶𝗻𝗴 𝗶𝘁 𝘄𝗲𝗹𝗹?”

👉🏼The answer matters, because these are two very different problems with two very different solutions.

📌Dose-related symptoms tend to be immediate and proportional. When estrogen is too stimulating, symptoms usually improve quickly with dose reduction.

➡️Metabolism-related symptoms, on the other hand, are delayed, inflammatory, and often cyclical. They build over time because estrogen isn’t being cleared efficiently through the liver and gut.

🥦This is where many women get stuck. If estrogen metabolism is the issue, lowering the dose doesn’t fix the physiology it often worsens symptoms like hot flashes, poor sleep, or bone vulnerability.

🗓️𝗧𝗶𝗺𝗶𝗻𝗴 𝗶𝘀 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗶𝗺𝗽𝗼𝗿𝘁𝗮𝗻𝘁 𝗰𝗹𝘂𝗲𝘀. 𝗙𝗮𝘀𝘁 𝗳𝗲𝗲𝗱𝗯𝗮𝗰𝗸 𝗽𝗼𝗶𝗻𝘁𝘀 𝘁𝗼 𝗱𝗼𝘀𝗲. 𝗦𝗹𝗼𝘄 𝗯𝘂𝗶𝗹𝗱𝘂𝗽 𝗽𝗼𝗶𝗻𝘁𝘀 𝘁𝗼 𝗰𝗹𝗲𝗮𝗿𝗮𝗻𝗰𝗲.

👉🏼Estradiol levels alone don’t answer this question. You have to look at estrogen metabolites, liver and gut function, inflammation, and stress physiology to understand what’s really happening.

Hormone therapy works best when we stop guessing and start asking better questions.

➡️ Follow for continued clinical hormone education.
💾 Save or share this if estrogen therapy left you confused instead of better.

𝘏𝘢𝘷𝘦 𝘺𝘰𝘶 𝘦𝘷𝘦𝘳 𝘣𝘦𝘦𝘯 𝘵𝘰𝘭𝘥 𝘵𝘰 “𝘫𝘶𝘴𝘵 𝘭𝘰𝘸𝘦𝘳 𝘵𝘩𝘦 𝘥𝘰𝘴𝘦” 𝘸𝘪𝘵𝘩𝘰𝘶𝘵 𝘢𝘯𝘺𝘰𝘯𝘦 𝘦𝘹𝘱𝘭𝘢𝘪𝘯𝘪𝘯𝘨 𝘸𝘩𝘺?

02/04/2026

𝗬𝗼𝘂 𝘄𝗼𝘂𝗹𝗱𝗻’𝘁 𝘄𝗮𝗶𝘁 𝘂𝗻𝘁𝗶𝗹 𝗿𝗲𝘁𝗶𝗿𝗲𝗺𝗲𝗻𝘁 𝘁𝗼 𝘀𝘁𝗮𝗿𝘁 𝘀𝗮𝘃𝗶𝗻𝗴 𝗺𝗼𝗻𝗲𝘆...𝗯𝗲𝗰𝗮𝘂𝘀𝗲 𝗯𝘆 𝘁𝗵𝗲𝗻, 𝘁𝗵𝗲 𝗱𝗮𝗺𝗮𝗴𝗲 𝗶𝘀 𝗮𝗹𝗿𝗲𝗮𝗱𝘆 𝗱𝗼𝗻𝗲. 💡
❌ So why are women told to wait until postmenopause to think about hormones?

𝗣𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗶𝘀 𝘁𝗵𝗲 𝗶𝗻𝘃𝗲𝘀𝘁𝗺𝗲𝗻𝘁 𝘄𝗶𝗻𝗱𝗼𝘄. 🧠
It’s the decade where hormone signaling becomes unstable — not absent and that instability drives real, measurable changes.

𝗪𝗵𝗮𝘁’𝘀 𝗵𝗮𝗽𝗽𝗲𝗻𝗶𝗻𝗴 𝗾𝘂𝗶𝗲𝘁𝗹𝘆 𝗱𝘂𝗿𝗶𝗻𝗴 𝘁𝗵𝗶𝘀 𝗽𝗵𝗮𝘀𝗲:
• 🦴 Accelerated bone loss
• 🫀 Early endothelial dysfunction
• 🍬 Worsening insulin sensitivity
• 😴 Fragmented sleep
• 🧠 Neuroinflammation and brain fog

By the time menopause is diagnosed, many systems have already adapted to years of hormonal volatility not just low estrogen.

⏰ 𝗧𝗵𝗶𝘀 𝗶𝘀 𝘄𝗵𝘆 𝘁𝗵𝗲 “𝘄𝗮𝗶𝘁 𝗶𝘁 𝗼𝘂𝘁” 𝗮𝗽𝗽𝗿𝗼𝗮𝗰𝗵 𝗳𝗮𝗶𝗹𝘀 𝘀𝗼 𝗺𝗮𝗻𝘆 𝘄𝗼𝗺𝗲𝗻.

➡️ Hormones were never meant to be a last-ditch rescue.
They’re part of preventive, long-term health strategy when used thoughtfully and early alongside sleep, metabolism, muscle, and nervous system support.

If you’ve been told your labs are “normal” or that you’re “too young,” you’re not behind you’re early. ✅

👉🏻 𝗙𝗼𝗹𝗹𝗼𝘄 𝗳𝗼𝗿 𝗲𝘃𝗶𝗱𝗲𝗻𝗰𝗲-𝗯𝗮𝘀𝗲𝗱 𝗽𝗲𝗿𝗶𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗲𝗱𝘂𝗰𝗮𝘁𝗶𝗼𝗻.
📌 Comment “LABS” and I’ll share my full list of perimenopause labs I recommend on my Substack and why each one matters.

02/03/2026

❤️𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆 𝗶𝘀 𝗛𝗲𝗮𝗿𝘁 𝗛𝗲𝗮𝗹𝘁𝗵 𝗔𝘄𝗮𝗿𝗲𝗻𝗲𝘀𝘀 𝗠𝗼𝗻𝘁𝗵, 𝗮𝗻𝗱 𝘄𝗲’𝗿𝗲 𝗵𝗼𝘀𝘁𝗶𝗻𝗴 𝗮 𝗹𝗶𝘃𝗲 𝘄𝗲𝗯𝗶𝗻𝗮𝗿 𝗳𝗼𝗰𝘂𝘀𝗲𝗱 𝗼𝗻 𝗽𝗿𝗼𝗮𝗰𝘁𝗶𝘃𝗲 𝗰𝗮𝗿𝗱𝗶𝗼𝘃𝗮𝘀𝗰𝘂𝗹𝗮𝗿 𝗵𝗲𝗮𝗹𝘁𝗵 𝗮𝗻𝗱 𝗹𝗼𝗻𝗴𝗲𝘃𝗶𝘁𝘆.

Join us on February 16 from 12:15–12:45 PM to learn how advanced longevity testing can identify early cardiovascular risk, optimize metabolic markers, and support long-term heart health before symptoms start.

Live attendee exclusive:

Attend live and receive 15% off supplements with the purchase of a Longevity Panel.

This webinar is open exclusively to Yoo Direct Health patients.

𝗛𝗼𝘄 𝘁𝗼 𝘀𝗶𝗴𝗻 𝘂𝗽:
Message us in the patient portal or text/call 317-523-9160.
Preventative care starts with better data and better decisions.

02/02/2026

𝗣𝗼𝘀𝘁𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗮𝗹 𝗵𝗼𝗿𝗺𝗼𝗻𝗲 𝗹𝗮𝗯𝘀 𝗮𝗿𝗲 𝗼𝗳𝘁𝗲𝗻 𝗹𝗮𝗯𝗲𝗹𝗲𝗱 “𝗻𝗼𝗿𝗺𝗮𝗹” 𝘄𝗵𝗶𝗹𝗲 𝘀𝘆𝗺𝗽𝘁𝗼𝗺𝘀, 𝗯𝗼𝗻𝗲 𝗹𝗼𝘀𝘀, 𝗮𝗻𝗱 𝗰𝗮𝗿𝗱𝗶𝗼𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗿𝗶𝘀𝗸 𝗰𝗼𝗻𝘁𝗶𝗻𝘂𝗲 𝘁𝗼 𝗿𝗶𝘀𝗲. 𝗧𝗵𝗮𝘁 𝗱𝗶𝘀𝗰𝗼𝗻𝗻𝗲𝗰𝘁 𝗺𝗮𝘁𝘁𝗲𝗿𝘀. 🧠

Menopause confirms ovarian shutdown.
It does not mean hormones stop influencing health.

Here’s the clinical nuance most women are never taught 👇

🔬 Estradiol:
In untreated postmenopause, estradiol is commonly 60 pg/mL, often closer to ~100 pg/mL, individualized to symptoms and response.

📈 FSH:
FSH confirms menopause but in practice, I’ve found that keeping FSH

Lexi Yoo, FNP, IFMCP

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