Lexi Yoo, FNP, IFMCP

04/04/2026

Why Dutch testing?

Advanced Hormone Metabolite Testing with DUTCH | Dr. Brooke Ahnemann & Lexi Yoo, NP | CALM 2026At the Clinical Application of Longevity Medicine 2026 confere...

04/04/2026

Not all GLP-1–based medications produce the same amount of weight loss.

And the differences are clinically meaningful.

📊 Here’s a simplified breakdown from major trials:

Orforglipron (oral GLP-1)
• ~11% average weight loss
• ~72 weeks
• Dose-dependent response 

Semaglutide (GLP-1)
• ~12–15% average weight loss
• ~68 weeks
• STEP trial data

Tirzepatide (GLP-1 + GIP)
• ~15–22% average weight loss
• ~72 weeks
• SURMOUNT trials

⚖️ Important context:

These are not head-to-head trials, so exact comparisons have limits.
But the pattern is consistent.

🧠 Why the difference?

• Semaglutide → single GLP-1 pathway
• Tirzepatide → dual incretin effect (GLP-1 + GIP) → greater metabolic impact
• Orforglipron → same GLP-1 receptor, but oral delivery and slightly lower overall effect size

So where does that leave orforglipron?

👉 Slightly less weight loss
👉 Much easier administration

No injections. No refrigeration. Simpler adherence.

That tradeoff may matter more than people think.

❤️Follow along if you want clearer conversations about GLP-1s and metabolic health.
💾 Save this so you can compare options later.

Question: If you’re considering treatment, what matters more to you, maximum weight loss or ease of use?

04/04/2026

Irregular periods in your 40s are not caused by “low hormones.”
They’re driven by fluctuation first — deficiency comes later.

This is where most women get dismissed.

🔬 In early perimenopause, estrogen is erratic — not low
It can spike, drop, and shift within the same cycle

🧠 Progesterone is the first to decline
Because ovulation becomes inconsistent — not because your body “stopped”

⚖️ That mismatch changes your cycle:
➡️ Shorter, then longer
➡️ Heavier, then lighter
➡️ Skipped, then clustered

📉 True deficiency happens later
But symptoms start during this instability phase

🧪 This is also why labs confuse people
Timing matters more than the number

If you’re still cycling, here’s what actually helps:
➡️ Estradiol + FSH → check day 2–4 of your cycle
➡️ Progesterone → check ~5–7 days after ovulation (not “day 21” for everyone)
➡️ Thyroid panel → any time
➡️ Fasting insulin / glucose → any time

📊 One lab doesn’t define perimenopause
Patterns over time do!

💾Save this post for lab timing reference

👉🏼Have your cycles gotten closer together, farther apart… or both?

04/03/2026

𝗠𝗼𝘀𝘁 𝗽𝗿𝗼𝘃𝗶𝗱𝗲𝗿𝘀 𝗱𝗼𝗻’𝘁 𝗮𝘃𝗼𝗶𝗱 𝗛𝗥𝗧 𝗯𝗲𝗰𝗮𝘂𝘀𝗲 𝘁𝗵𝗲𝘆 𝗱𝗼𝗻’𝘁 𝗯𝗲𝗹𝗶𝗲𝘃𝗲 𝗶𝗻 𝗶𝘁.
👉🏻They avoid it because they don’t feel fully confident prescribing it. Or they only know how to prescribe 𝟭 𝗺𝗼𝗱𝗮𝗹𝗶𝘁𝘆?

👉🏻If you’re a practitioner, and this sounds like you, 𝘊𝘰𝘮𝘮𝘦𝘯𝘵: 𝗛𝗥𝗧 to get a link to sign up for the HRT practice accelerator bundle!

𝗦𝗼 𝘄𝗵𝘆 𝘁𝗵𝗲 𝗵𝗲𝘀𝗶𝘁𝗮𝘁𝗶𝗼𝗻?
It 𝘂𝘀𝘂𝗮𝗹𝗹𝘆 𝗰𝗼𝗺𝗲𝘀 𝗱𝗼𝘄𝗻 𝘁𝗼 𝗮 𝗳𝗲𝘄 𝗸𝗲𝘆 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝘀:
👉🏻When do I start?
👉🏻What do I base decisions on?
👉🏻Which route is best?
👉🏻How do I dose safely?
👉🏻What about complex patients?

These aren’t simple questions.
And they shouldn’t be.

🔑Because HRT done well is not just protocol-driven, it’s clinical decision-making. Or what I like to call pattern recognition!

That’s exactly what we focus on inside our training; bridging the gap between theory and real-world application. From classroom to clinic!

If you’ve been wanting to add HRT into your practice (or do it better), this is where that shift happens.

📅 March 29 – April 5 (ends at 11:59 PM!)

𝗙𝗼𝗿 𝗢𝗡𝗘 𝗪𝗘𝗘𝗞 𝗢𝗡𝗟𝗬: 𝘄𝗲’𝗿𝗲 𝗴𝗶𝘃𝗶𝗻𝗴 𝘆𝗼𝘂 𝘁𝗵𝗲 𝘂𝗹𝘁𝗶𝗺𝗮𝘁𝗲 𝗿𝗲𝘀𝗼𝘂𝗿𝗰𝗲 𝘁𝗼 𝗺𝗮𝘀𝘁𝗲𝗿𝗶𝗻𝗴 𝗛𝗥𝗧 𝗮𝗻𝗱 𝗯𝘂𝗶𝗹𝗱𝗶𝗻𝗴 𝗮 𝗽𝗿𝗼𝗳𝗶𝘁𝗮𝗯𝗹𝗲, 𝗺𝗼𝗱𝗲𝗿𝗻 𝗽𝗿𝗮𝗰𝘁𝗶𝗰𝗲 👇

💥 Buy the Women’s Health 𝗢𝗥 Men’s Health Module
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𝗧𝗵𝗶𝘀 𝗶𝘀 𝗵𝗮𝗻𝗱𝘀-𝗼𝗻, 𝗿𝗲𝗮𝗹-𝘄𝗼𝗿𝗹𝗱 𝘁𝗿𝗮𝗶𝗻𝗶𝗻𝗴 𝗱𝗲𝘀𝗶𝗴𝗻𝗲𝗱 𝘁𝗼 𝗵𝗲𝗹𝗽 𝘆𝗼𝘂:
✔️ Confidently prescribe and optimize HRT
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If you’ve been waiting to refine your hormone offerings in your practice, expand your services, and step into more advanced care… this is your moment.

👉 Secure your spot: www.ydhacademy.com

04/02/2026

𝙔𝙊𝙊 𝙂𝙍𝙊𝙒 𝙃𝘼𝙄𝙍.... 💉 injecting my advanced hair protocols- mixing advanced 𝗴𝗿𝗼𝘄𝘁𝗵 𝗳𝗮𝗰𝘁𝗼𝗿𝘀 and 𝗽𝗲𝗽𝘁𝗶𝗱𝗲 𝘁𝗵𝗲𝗿𝗮𝗽𝘆!

🔗Comment HAIR to get the link to my favorite hair support supplements and peptides like BPC157 and GHkcu

𝙂𝙃𝙆-𝘾𝙐- Naturally occurring copper complex that can activate healing, decreases inflammation, and has antioxidant and immune boosting effects. Can initiate growth and repair of hair follicles.

𝗧𝗕𝟰- Natural peptide produced by the thymus gland that is naturally released that is released in body in response to injury to stimulate healing, decrease inflammation, and increase follicle repair. Can regulate actin levels to stimulate tissue cell growth and promote blood vessel formation.

𝗕𝗣𝗖 𝟭𝟱𝟳- Natural peptide found in the gastric juices in our gut that can help with tissue repair. Can accelerate healing, increases growth hormone receptors, anti-inflammatory, promotes angiogenesis (blood vessel formation)! Also one of my favorite gut peptides... Can promote tissue healing through signaling pathways.

𝗧𝗵𝗶𝘀 𝗶𝘀 𝗯𝘆 𝗳𝗮𝗿 𝗼𝗻𝗲 𝗼𝗳 𝗺𝘆 𝗳𝗮𝘃𝗼𝗿𝗶𝘁𝗲 𝗿𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗽𝗿𝗼𝗰𝗲𝗱𝘂𝗿𝗲𝘀 𝗜 𝗱𝗼!
💉 A ring 💍 block is performed for comfort, because yes all of those things are injected in the scalp!
📲 To book a consult call or text (317)523-9160

💉Comment HAIR to get the link to my favorite hair support supplements and peptides like BPC157 and GHkcu

📚 𝗪𝗮𝗻𝘁 𝘁𝗼 𝗹𝗲𝗮𝗿𝗻 𝘁𝗵𝗶𝘀 𝗽𝗿𝗼𝘁𝗼𝗰𝗼𝗹? Check out the

04/02/2026

𝗗𝘂𝘁𝗮𝘀𝘁𝗲𝗿𝗶𝗱𝗲 𝗶𝘀 𝘁𝘆𝗽𝗶𝗰𝗮𝗹𝗹𝘆 𝗳𝗿𝗮𝗺𝗲𝗱 𝗮𝘀 𝗮 “𝗗𝗛𝗧 𝗯𝗹𝗼𝗰𝗸𝗲𝗿.”

That’s incomplete and clinically limiting.

What’s often missed is its role in neurosteroid metabolism.

Here’s the key shift:

🧠 Progesterone is not the endpoint
It’s a precursor to allopregnanolone, a GABA-modulating neurosteroid

🔄 When 5α-reductase is inhibited, that conversion is reduced
Meaning less allopregnanolone—regardless of progesterone levels

⚖️ This helps explain why some patients experience:

Mood changes
Anxiety shifts
Sleep disruption
Cycle-specific symptom patterns

And in PMDD specifically, the issue isn’t “high progesterone”—
it’s sensitivity to neurosteroid fluctuation

That’s why higher-dose dutasteride has shown benefit:
it stabilizes that pathway.

This is a good reminder:
𝗛𝗼𝗿𝗺𝗼𝗻𝗲𝘀 𝗱𝗼𝗻’𝘁 𝗮𝗰𝘁 𝗶𝗻 𝗶𝘀𝗼𝗹𝗮𝘁𝗶𝗼𝗻 𝘁𝗵𝗲𝗶𝗿 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘁𝗲𝘀 𝗺𝗮𝘁𝘁𝗲𝗿 𝗷𝘂𝘀𝘁 𝗮𝘀 𝗺𝘂𝗰𝗵.

Comment 𝐒𝐮𝐛𝐬𝐭𝐚𝐜𝐤 to get my full article on using Dutasteride.

Have you seen mood or cycle shifts in patients on 5α-reductase inhibitors?🤔🤓

04/01/2026

𝗜 𝗵𝗮𝘃𝗲 𝘁𝗵𝗲 𝗯𝗲𝘀𝘁 𝗷𝗼𝗯 𝗲𝘃𝗲𝗿! Let me tell you why....
👉🏻This morning in clinic looked like this: helping women in menopause lose fat without sacrificing muscle by using all the tools in the tool box! Because that’s the part most plans get wrong.

⚖️ 𝗙𝗮𝘁 𝗹𝗼𝘀𝘀 𝗶𝗻 𝗺𝗲𝗻𝗼𝗽𝗮𝘂𝘀𝗲 𝗶𝘀 𝗻𝗼𝘁 𝗮𝗯𝗼𝘂𝘁 𝗲𝗮𝘁𝗶𝗻𝗴 𝗹𝗲𝘀𝘀.
It’s about optimizing hormones and protecting lean mass.

🧠 𝗪𝗵𝗮𝘁 𝗱𝗼 𝗜 𝗺𝗲𝗮𝗻 𝗯𝘆 𝗯𝘆 𝗛𝗼𝗿𝗺𝗼𝗻𝗲 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗮𝘁𝗶𝗼𝗻?
Estradiol supports insulin sensitivity and where your body stores fat
Progesterone impacts sleep, recovery, and nervous system stability. Testosterone drives muscle mass, strength, and metabolic rate

𝗜𝗳 𝘁𝗵𝗲𝘀𝗲 𝗮𝗿𝗲𝗻’𝘁 𝗮𝗱𝗱𝗿𝗲𝘀𝘀𝗲𝗱, 𝗳𝗮𝘁 𝗹𝗼𝘀𝘀 𝗯𝗲𝗰𝗼𝗺𝗲𝘀 𝗮 𝗰𝗼𝗻𝘀𝘁𝗮𝗻𝘁 𝘂𝗽𝗵𝗶𝗹𝗹 𝗯𝗮𝘁𝘁𝗹𝗲.

🏋️‍♀️ Muscle is the strategy and the organ of longevity, let me break it down 👇🏻
Creatine supports strength, recovery, and cellular energy
Essential amino acids help preserve and build lean mass
Because muscle is what determines your metabolism long-term.

📉 𝗣𝗲𝗽𝘁𝗶𝗱𝗲 𝗹𝗮𝘆𝗲𝗿 (𝘄𝗵𝗲𝗻 𝗮𝗽𝗽𝗿𝗼𝗽𝗿𝗶𝗮𝘁𝗲):
Tesamorelin → targets visceral fat through the GH pathway
Ipamorelin → supports growth hormone pulsatility and recovery
IGF-1 LR3 → downstream signaling for tissue repair and anabolic support ♥️ my personal favorite!

This is why tracking labs and inbody scans can tell so much more to a story! This is about changing body composition and long-term metabolic health.

💾 Save this so you can come back to it.
👑 Share it with someone frustrated with “doing everything right.”
♥️Follow for evidence-based menopause education.

Interested in my favorite Creatine and Amino stack?
🔗 Comment 𝗠𝗨𝗦𝗖𝗟𝗘 to get the link!

04/01/2026

⚠️𝗣𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗶𝘀 𝗼𝗻𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗺𝗼𝘀𝘁 𝗺𝗶𝘀𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗼𝗼𝗱 𝗵𝗼𝗿𝗺𝗼𝗻𝗲𝘀 𝗜 𝘀𝗲𝗲 𝗰𝗹𝗶𝗻𝗶𝗰𝗮𝗹𝗹𝘆.

➡️Not because it’s complicated, but because we oversimplify it.

➡️When someone says, “progesterone made me feel worse,” the assumption is often that it’s the wrong therapy. That’s not always true.

Here’s what’s actually happening 👇

• Progesterone works through GABA your brain’s calming pathway
• But that pathway has to be responsive for you to feel the benefit
• If it’s not, you can experience the opposite effect

This is what we call progesterone inversion a paradoxical response driven by receptor sensitivity, not just hormone levels.

And this is where timing and dosing matter more than most people realize:
• Progesterone peaks in the luteal phase, not randomly
• Blood levels fluctuate quickly after dosing
• “Normal labs” don’t always reflect tissue-level response

⬇️𝗟𝗼𝘄 𝗽𝗿𝗼𝗴𝗲𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗶𝘀 𝗮𝗹𝘀𝗼 𝗿𝗮𝗿𝗲𝗹𝘆 𝗮 𝘀𝘁𝗮𝗻𝗱𝗮𝗹𝗼𝗻𝗲 𝗶𝘀𝘀𝘂𝗲. 𝗜𝘁’𝘀 𝗼𝗳𝘁𝗲𝗻 𝗮 𝘀𝗶𝗴𝗻𝗮𝗹: 𝗼𝘃𝘂𝗹𝗮𝘁𝗶𝗼𝗻, 𝘀𝘁𝗿𝗲𝘀𝘀, 𝘁𝗵𝘆𝗿𝗼𝗶𝗱, 𝗼𝗿 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗱𝘆𝘀𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻 𝗮𝗿𝗲 𝗶𝗻𝘃𝗼𝗹𝘃𝗲𝗱.

This is why simply “adding progesterone” without context can miss the bigger picture.

Follow for more clinical, physiology-based hormone education.
💾 Save this if you’re trying to better understand your labs or symptoms.

𝙃𝙖𝙫𝙚 𝙮𝙤𝙪 𝙚𝙫𝙚𝙧 𝙛𝙚𝙡𝙩 𝙬𝙤𝙧𝙨𝙚 𝙤𝙣 𝙥𝙧𝙤𝙜𝙚𝙨𝙩𝙚𝙧𝙤𝙣𝙚 𝙖𝙣𝙙 𝙙𝙞𝙙𝙣’𝙩 𝙠𝙣𝙤𝙬 𝙬𝙝𝙮?

04/01/2026

♥️𝗘𝘃𝗲𝗿𝘆𝗼𝗻𝗲 𝘁𝗵𝗶𝗻𝗸𝘀 𝘁𝗵𝗲𝗶𝗿 𝘀𝗲𝘅 𝗹𝗶𝗳𝗲 𝘄𝗶𝗹𝗹 𝗳𝗮𝗱𝗲 𝘄𝗶𝘁𝗵 𝗮𝗴𝗲. 𝗧𝗵𝗮𝘁 𝗯𝗲𝗹𝗶𝗲𝗳 𝗺𝗶𝗴𝗵𝘁 𝗯𝗲 𝘁𝗵𝗲 𝗿𝗲𝗮𝗹 𝗽𝗿𝗼𝗯𝗹𝗲𝗺.

👉🏻One of the biggest misconceptions in sexual wellness for both men and women is that decline is inevitable.

👉🏻We’ve normalized the story:
The tired partner with no libido.
The midlife er****on issues.
The slow fade after a few years of marriage.

And then we joke about it.

But those jokes train us to expect dysfunction.

🔥𝗪𝗵𝗲𝗻 𝘆𝗼𝘂 𝗯𝗲𝗹𝗶𝗲𝘃𝗲 𝘀𝗼𝗺𝗲𝘁𝗵𝗶𝗻𝗴 𝗶𝘀 “𝗷𝘂𝘀𝘁 𝗽𝗮𝗿𝘁 𝗼𝗳 𝗹𝗶𝗳𝗲,” 𝘆𝗼𝘂 𝘀𝘁𝗼𝗽 𝗾𝘂𝗲𝘀𝘁𝗶𝗼𝗻𝗶𝗻𝗴 𝗶𝘁. 𝗬𝗼𝘂 𝘀𝘁𝗼𝗽 𝗹𝗼𝗼𝗸𝗶𝗻𝗴 𝗳𝗼𝗿 𝘄𝗵𝗮𝘁’𝘀 𝗮𝗰𝘁𝘂𝗮𝗹𝗹𝘆 𝗱𝗿𝗶𝘃𝗶𝗻𝗴 𝘁𝗵𝗲 𝗰𝗵𝗮𝗻𝗴𝗲 𝘄𝗵𝗲𝘁𝗵𝗲𝗿 𝘁𝗵𝗮𝘁’𝘀 𝗹𝗶𝗳𝗲𝘀𝘁𝘆𝗹𝗲, 𝗵𝗼𝗿𝗺𝗼𝗻𝗲𝘀, 𝗼𝗿 𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻𝘀𝗵𝗶𝗽 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀.

Sexual health doesn’t just switch off with time.

What if the issue isn’t aging—but what we’ve been taught to accept about aging?

Follow @‌lexiyoonp for more education.

𝘏𝘢𝘷𝘦 𝘸𝘦 𝘯𝘰𝘳𝘮𝘢𝘭𝘪𝘻𝘦𝘥 𝘴𝘦𝘹𝘶𝘢𝘭 𝘥𝘺𝘴𝘧𝘶𝘯𝘤𝘵𝘪𝘰𝘯 𝘴𝘰 𝘮𝘶𝘤𝘩 𝘵𝘩𝘢𝘵 𝘱𝘦𝘰𝘱𝘭𝘦 𝘥𝘰𝘯’𝘵 𝘦𝘷𝘦𝘯 𝘵𝘳𝘺 𝘵𝘰 𝘧𝘪𝘹 𝘪𝘵 𝘢𝘯𝘺𝘮𝘰𝘳𝘦? 🤔🔥💬

🎬Catch the full episode on Apple or Spotify or watch it on my YouTube channel!

04/01/2026

One of my patients let her testosterone pellet wear off over 6 months.

She told me:
“I didn’t think it was doing anything.”

Until it was gone.

Here’s what came back:

💤 Fatigue she hadn’t felt in months
🧠 Brain fog and slower thinking
📉 Loss of motivation and drive
❤️‍🔥 Low libido and sexual disconnect
💪 Decreased strength and muscle tone
📊 Body composition shifting despite the same routine

Nothing dramatic.
Just… a slow shift back.

This is the part that gets missed.

When hormones improve gradually, they don’t feel like a “treatment.”
They feel like you.

So when patients say, “I don’t think it’s doing anything”—
what they often mean is:

“I’ve adapted to feeling better.”

Testosterone in women supports energy, cognition, muscle, and motivation.
When levels decline again, those systems feel it.

The goal isn’t just to be “fine.”
It’s to function optimally.

Follow for evidence-based hormone education.
Save this if you’ve ever questioned whether something was “working.”

Have you ever stopped something and only realized later how much it was helping? What was it?

04/01/2026

💉One of the most common things I hear:
“Some weeks my GLP-1 works… and some weeks it doesn’t.”

That’s not inconsistency, it’s your body’s physiology!

GLP-1 medications work within your system not outside of it. So when your system shifts, your response shifts too.

Here’s what actually changes week to week:

💉 Injection site affects absorption more than most people realize
🥩 Low protein or inconsistent intake increases fatigue and nausea
💧 Hydration directly impacts gastric emptying and GI side effects
🧠 Sleep and stress alter cortisol, glucose, and appetite signaling
🔄 Hormonal fluctuations especially in the luteal phase shift hunger and insulin sensitivity

Your body is not static.
So your response won’t be either.

❌This is where people get it wrong
they assume the dose stopped working.

But often, the variable isn’t the medication.
It’s what your body is doing that week!

👉🏼Have you noticed certain weeks feel completely different than others?