CPKS, LLP Uncensored Family Medicine

11/29/2025

Seizures are electrical storms, and anyone who has lived with epilepsy knows that these storms can roll in without warning. Beneath that activity lies the ECS, our Master Regulator, working to steady the flow of signals through the brain. When calcium floods into neurons too quickly, those cells fire in rapid chains that feed a seizure. The brain needs a system that can ease that surge, guide ion flow, and shift excitatory pathways back toward balance. That is where CBGa shows real strength.

The study Cannabigerolic Acid Is a Highly Potent Seizure Suppressant in a Mouse Model of Dravet Syndrome (2021) demonstrated that CBGa interacts with ion channels tied to neuronal firing. Calcium channels, sodium channels, and TRP receptors all play roles in how fast a neuron discharges and recovers.

When CBGa binds to specific TRP sites, especially TRPV1, it changes how calcium is allowed to move through the membrane. It does not shut the door; it steadies the swing. That steadier flow prevents the kind of runaway excitation that builds into a seizure.
Epileptic brains often struggle with overactive glutamate signalling and weakened GABA tone.

Without enough internal modulators to slow the cycle, electrical activity spreads across networks that should remain quiet. CBGa supports the upstream pathways that feed those modulators, allowing the Master Regulator to keep excitation and inhibition at a healthier rhythm. Patients feel that shift as fewer spikes, less aura activity, and more room for the brain to recover between stressors.

There is also the mitochondrial angle. Calcium overload stresses those little power units, leading to oxidative strain that tightens the seizure threshold. CBGa supports a healthier mitochondrial tone, helping neurons withstand stress without collapsing into hyperexcitability. That protection matters for long-term seizure control because a calmer calcium flow equals calmer circuits.

When the Master Regulator has what it needs, seizure thresholds rise, storms settle faster, and the brain finds the balance it has been missing.

Reach out if you need more information or a consultation.

-Mike Robinson, The Researcher OG

11/24/2025

A 19-year-old college football player was charged with DUI, but we now know he was sober when he was arrested.Channel 2 Action News Investigates reported on ...

11/23/2025

People think cannabis helps PTSD because it "calms you down," but that barely scratches the surface. The real power is how it lets the brain look at the memory without getting swallowed by the panic that usually comes with it. Trauma locks people into a loop where the body reacts first and the mind follows, and that cycle makes healing feel impossible. Cannabis gives the brain enough space to witness what happened instead of reliving it through a full sympathetic surge.

The ECS, our Master Regulator, plays a major role here because PTSD is really an endocannabinoid deficit wrapped in memories that hit too hard.

When anandamide is low the threat system stays hot, the amygdala stays reactive, and the hippocampus struggles to file the memory correctly. THC and CBD shift that neurocircuitry. THC softens the emotional load while CBD steadies the CB1 signal so the person does not get thrown back into panic. That combination lets the brain revisit the memory with less volatility, which is exactly what trauma therapy needs to work.

A major study that captured this effect is Cannabis Use and PTSD Symptom Severity in Military Veterans: A Longitudinal Study (Bonn Miller et al., 2015). It found that patients using cannabis reported meaningful reductions in intrusive recollections, hyperarousal, and avoidance patterns. It wasn't about numbing out - it was about gaining enough internal regulation to process trauma with clarity instead of fear.

Cannabis does not erase the past. It changes how the body reacts when the memory arises. That shift gives patients a bridge between what happened and who they are now. When the panic eases, the brain can finally reorganize the experience, and that is the doorway to real recovery.

This superpower people miss when they only focus on the high. Cannabis offers presence without the overwhelm. It gives trauma survivors the moment of safety they need to step toward their own healing instead of running from it.

-Mike Robinson, The Researcher OG

11/22/2025

11/20/2025