American Journal of Neuroradiology

11/07/2025

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11/07/2025

Mark your calendars – November 10-14 is Quality Week!

AJNR Celebrates Quality Week: Discover How Neuroradiologists are advancing imaging to make it safer, smarter, and better for patients.

Supported by and AJNR.

10/31/2025

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10/31/2025

Check the last Fellows’ Journal Club choice for the month: ‘ Nontrauma-Associated Cerebral Fat Embolism Syndrome in Sickle Cell–Related Hemoglobinopathies: A Case Series and Systematic Review‘. CFE in sickle cell–related hemoglobinopathies is more common in complex hemoglobinopathies with otherwise milder disease course and is typically more fulminant compared with traumatic CFE. While head CT images are usually negative, brain MRI findings follow a dynamic pattern with scattered foci of restricted diffusion, best known as the starfield pattern, presenting for a short period of time during the acute phase. Punctate foci of microhemorrhage appear slightly later during the acute phase, peak during the subacute phase, and persist for up to 6 months. Awareness of radiologists regarding nontrauma-associated CFE in patients with sickle cell–related disorders is crucial. Understanding the time course of imaging findings is helpful for accurate diagnosis and differentiation from similar conditions. https://www.ajnr.org/content/46/10/2000

10/31/2025

>> October 30, 2025 >> What is the diagnosis for this 46-year-old man with seizures for more than 2 months. Submit your answer at https://ow.ly/n9rL50XkvhT.

10/27/2025

Check our Fellows Journal Club for the month: ‘MR Imaging versus Noncontrast CT for Selecting Patients with Acute Ischemic Stroke of Large Vessel Occlusion for Endovascular Thrombectomy: A Systematic Review and Meta-Analysis’
Though EVT was safer and tended to be more effective in patients selected by MRI, the differential outcomes based on the treatment window deserve attention and highlight the importance of timely intervention. More advanced imaging is typically used in practice to refine patient selection in the extended time window. Yet, results of this study suggest that beyond 6 hours, the choice of imaging technique may actually become less impactful on overall outcomes. This suggests that in extended time windows, the focus should perhaps shift more toward ensuring rapid access to EVT rather than the choice of imaging technique. Access to treatment and avoiding exclusion of patients with LVO who may benefit from EVT should be prioritized. In that sense, NCCT remains a valid option because of its rapid acquisition and widespread availability. While MRI may refine patient selection and reduce the chances of futile recanalization, it can overestimate the size of the ischemic core and lead to inappropriate exclusion from treatment of patients who can benefit from reperfusion. Future research should further investigate the merits of these 2 imaging modalities, balancing precision with accessibility and the competing interests of reducing rates of futile recanalization while maximizing the identification of good candidates for EVT. https://www.ajnr.org/content/46/10/2026 ☢️

10/26/2025

Check our Fellows Journal Club for the month: ‘Clinical Impact of Sinus CT Surveillance Imaging among Febrile Neutropenic Patients: A Retrospective Observational Study’ Most CT sinus examinations performed for febrile neutropenia showed no evidence of acute sinusitis or revealed stable or improving disease. Many patients had more than 1 CT sinus examination in a 3-month period. Furthermore, imaging results, positive or negative, did not directly influence adjustments in antimicrobial management. Otorhinolaryngology consultations were requested based on positive imaging findings but in the absence of clinical features of sinusitis were unrevealing as to source of fever, which underscores the relatively low specificity of imaging findings for sinusitis in the absence of supportive clinical features. For these reasons, broad use of routine sinus CT as a screening method may be considered low-yield in the setting of febrile neutropenia. However, what defines appropriate value-based imaging in this vulnerable population is an evolving concept that requires further analysis and discourse. https://www.ajnr.org/content/46/10/2162

10/24/2025

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10/24/2025

10/23/2025

Check one of Editor’s choice for October:
‘Differentiation between Nonenhancing Tumor in Glioblastoma and Vasogenic Edema Using Diffusion-Weighted and Dynamic Susceptibility Contrast MR Imaging’

This study highlights the utility of diffusion- and perfusion-weighted MR imaging in differentiating nonenhancing glioblastoma from vasogenic edema. Nonenhancing glioblastomas have significantly lower ADC values and higher rCBV values compared with vasogenic edema, reinforcing their potential as imaging biomarkers. Additionally, while ADC values were comparable between perilesional nonenhancing T2-FLAIR hyperintensity around enhancing glioblastomas and vasogenic edema, rCBV remained a distinguishing factor, with values above 0.42 suggesting potential tumor infiltration.
These findings provide clinically relevant insights into glioblastoma lesion characterization, potentially enabling more precise, image-guided management. They may also improve the preoperative differentiation of glioblastomas from metastases by assessing perilesional ADC and rCBV values. However, given the variability in tumor infiltration and the continuous nature of perfusion and diffusion changes, these threshold values should be applied with caution in broader clinical settings.

https://www.ajnr.org/content/46/10/2116.