11/02/2025
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A new study may explain why certain patients experience dangerous side effects after MRI scans using gadolinium-based contrast dyes. While most people tolerate these dyes well, some suffer from symptoms like itching, headaches, or, in rare cases, severe conditions such as nephrogenic systemic fibrosis, which can lead to organ damage or even death.
Researchers have uncovered a possible link between gadolinium and oxalic acid, a natural compound found in foods like spinach, chocolate, sweet potatoes, almonds, and even vitamin C supplements. In lab tests, gadolinium was seen detaching from its dye and binding with oxalic acid. These newly formed compounds may enter cells and accumulate in organs, increasing health risks.
Oxalic acid is already known for its role in forming kidney stones by binding with calcium. Now, its interaction with gadolinium could explain the harmful effects some patients face after contrast-enhanced MRIs.
Based on this evidence, scientists advise patients to avoid high-oxalate foods and vitamin C supplements before undergoing MRIs with contrast. This discovery could lead to updated safety recommendations and help protect vulnerable individuals in the future.
This breakthrough sheds light on a long-standing medical mystery and may reshape how we approach diagnostic imaging safety.