02/21/2026
Reflections from my lecture in Manhattan at IHS 2026:
Precision Cognitive Longevity: Integrative Strategies to Prevent and Slow Alzheimer’s Disease.
What molecule plays a critical role in supporting cerebral blood flow and helping drive the brain’s waste clearance systems?
Nitric oxide.
Nitric oxide supports:
• Endothelial function
• Vascular dilation
• Cerebral circulation
• Pulsatility that assists glymphatic clearance
• Mitochondrial efficiency
As we age, nitric oxide production naturally declines. This decline has been associated with reduced vascular flexibility, impaired metabolic resilience, and diminished brain perfusion.
Ways to support healthy nitric oxide production:
• Early morning sunlight exposure to reinforce circadian rhythm
• Strength training and regular movement
• Nasal breathing
• Maintaining a healthy oral microbiome including tongue scraping
• Antioxidant-rich nutrition such as berries and grapeseed extract
• Nitrate-rich vegetables including beets and leafy greens
In my clinical and educational work, I collaborate with in developing products that support nitric oxide pathways.
One reason I appreciate Neo40 Professional is that it targets both the nitrate–nitrite pathway and endothelial nitric oxide synthase support.
As always, supplements should be used in coordination with your physician or qualified healthcare practitioner.
These statements have not been evaluated by the FDA.
Dr. Yousef Elyaman
