04/23/2026
One of the most disorienting experiences is feeling overcome with anxiety without a clear understanding of why.
In some cases, this may not be coming from your thoughts at all.
Histamine, when elevated, can act directly on the brain as an excitatory signal. It can heighten activity within the limbic system, the part of the brain involved in fear, stress, and emotional processing.
This can look like fear without a story. A sense of urgency without a clear reason. A feeling of impending doom despite your mind's best efforts to stay calm.
If this experience feels familiar, it may be worth gently considering what is happening at a physiological level, not just a psychological one. For some, histamine can be a surprisingly illuminating piece to explore.
If histamine feels like a relevant piece for you, or something you are beginning to suspect, Dr. Lum’s comprehensive course on histamine intolerance and MCAS helps bring clarity to what may be happening in the body, along with insights and approaches that are not often addressed in conventional conversations around histamine intolerance and MCAS. Learn more at the link below.
https://dr-brian-lum-s-histamine-course.teachable.com/p/drbrianlum-histaminecourse
Haas, H. L., & Panula, P. (2003). The role of histamine and the tuberomammillary nucleus in the nervous system. Nature Reviews Neuroscience.