01/16/2026
The intentional or unintentional use of more than one substance within a short period of time is referred to as polysubstance use. Those who practice polysubstance use intentionally may do so to:
● Modify or enhance the effects of a single substance.
● Compensate for weakened effects of one substance.
● Prevent alcohol and op**te withdrawal symptoms.
● Attempt to alleviate some of the stresses related to previous trauma, life circumstances, and/or health issues.
● Replace their preferred drug of choice when it’s unavailable.
Unfortunately, polysubstance use isn’t rare, as those who use one substance often use another. In previous years, 90% of people with an opioid use disorder used more than 2 other substances within the last year, and more than 25% of these individuals had at least two other substance use disorders.
Despite its prevalence, polysubstance use is never safe. Even when prescription drugs are used in combination or with other substances, the effects of drug mixing can be unpredictable, stronger than either drug alone, and/or deadly.
Mixing two respiratory depressants such as alcohol and opioids (e.g., hydrocodone, oxycodone, etc.) is particularly dangerous. In fact, black-box warnings on prescription opioid labels advise against mixing these substances with alcohol, as doing so can produce severe respiratory depression, sedation, and heightened risk of overdose.
Combining alcohol with substances such as opioids also increases the risk of overdose toxicity and multiple other adverse health outcomes such as: over-sedation, impaired motor control, bodily injury, violence, risky sexual behavior, respiratory arrest, anoxic brain injury and other organ damage, alcohol and other substance use disorders, and fatal overdose.
To access this original American Addiction Centers webpage and learn more about the dangers of polysubstance use, please visit https://americanaddictioncenters.org/alcohol/mixing-opioids
To learn more about how Genesis Reference Laboratories can provide toxicology testing to aid in medication monitoring and detection of substance use, including alcohol, please call: (844) 510-0194.