10/14/2025
🧬 Comprehensive Lab Panel for Women Considering or Already on Hormone Therapy
Before Starting HRT (Baseline Labs)
To understand where your hormones stand, find the root of your symptoms, and create a safe, effective plan.
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Hormones
• Estradiol (E2): Measures your main estrogen level — too low can cause hot flashes, vaginal dryness, low libido; too high can cause bloating or breast tenderness.
• Progesterone: Balances estrogen, supports sleep and mood, and helps protect the uterine lining.
• Total & Free Testosterone: Supports muscle tone, libido, energy, and focus.
• DHEA-S: A precursor hormone that supports estrogen and testosterone production.
• SHBG (S*x Hormone Binding Globulin): Determines how much estrogen and testosterone are actually free (usable) in your body.
• LH & FSH: Help identify if you’re perimenopausal or postmenopausal and show how your ovaries are functioning.
• Cortisol (AM): Reflects adrenal stress levels; high or low cortisol can affect sleep, energy, and hormone balance.
• Prolactin: Elevated levels can suppress ovulation and lower estrogen/testosterone.
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Thyroid
Your thyroid works closely with your s*x hormones — an imbalance can mimic or worsen menopausal symptoms.
• TSH: The main screening test for thyroid function.
• Free T4 & Free T3: Show how well your thyroid hormones are being produced and converted to their active form.
• Reverse T3 (optional): Can show if stress or inflammation is blocking active thyroid hormone function.
• TPO & Thyroglobulin antibodies: Check for autoimmune thyroid issues like Hashimoto’s that can cause fatigue, hair loss, and weight changes.
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Metabolic & General Health
These tests help assess blood sugar, liver, kidney, and cardiovascular health — all critical for safe and effective hormone therapy.
• CBC (Complete Blood Count): Detects anemia or other blood disorders.
• CMP (Comprehensive Metabolic Panel): Checks liver and kidney function, electrolytes, and overall metabolic health.
• Fasting Glucose, Insulin, and Hemoglobin A1c: Show blood sugar control and insulin sensitivity — key for weight, energy, and hormone balance.
• Lipid Panel: Assesses cholesterol and triglycerides; estrogen often impacts lipid metabolism.
• hs-CRP: Marker of systemic inflammation that affects cardiovascular and metabolic health.
• Ferritin: Measures stored iron; low levels can cause fatigue and hair loss.
• Vitamin D (25-OH): Essential for bone, immune, and hormone health.
• Vitamin B12 & Folate: Support energy, mood, and red blood cell production.
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Follow-Up Labs
(Usually 8–12 weeks after starting or adjusting hormones, then every 6–12 months.)
To ensure your therapy stays balanced and safe.
• Estradiol
• Progesterone
• Total & Free Testosterone
• SHBG
• DHEA-S
• CMP
• Lipid panel
• Hemoglobin A1c
• CBC
• Vitamin D
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đź’ˇ Why It Matters:
Your hormones don’t work in isolation. They influence — and are influenced by — your thyroid, adrenals, liver, and blood sugar.
Comprehensive testing ensures your HRT is personalized, effective, and safe over time.
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⚠️ Disclaimer:
Educational only — not medical advice. Always consult your provider for individualized testing, interpretation, and treatment.