01/04/2026
**Treating Both Root and Manifestation to Dispel Wind–Cold:
Clinical Observation and Formula Analysis of a Modified Compound Based on Yu Ping Feng San Combined with Gui Zhi Tang for Chronic Wind–Cold–Type Allergic Rhinitis**
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Abstract
This study aims to observe and analyze the clinical efficacy of a compound honey-pill formula based on Yu Ping Feng San and Gui Zhi Tang, supplemented with herbs that tonify the kidney and essence, strengthen the spleen and resolve dampness, and dispel wind to open the nasal orifices, in the treatment of chronic wind–cold–type allergic rhinitis. Guided by the Traditional Chinese Medicine (TCM) principle of “treating both the root and the manifestation,” the formula targets the core pathomechanism of allergic rhinitis.
Through clinical observation of 500 patients in the Chaoshan region, it was found that after taking the honey pills (10 g per dose, twice daily, for a 60-day course), major symptoms such as rhinorrhea, sneezing, and ocular itching improved rapidly, with onset of effect within one day. One-year follow-up after discontinuation revealed no recurrence, demonstrating both significant short-term and long-term therapeutic efficacy. By integrating classical TCM theory, modern pharmacological research, and clinical observation data, this paper systematically elucidates the formulation principles, mechanisms of action, and the scientific rationale for accompanying dietary restrictions, and explores the potential of this formula as a standardized treatment protocol for integrative medicine clinics and international dissemination.
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Introduction
Allergic rhinitis (AR) is an IgE-mediated, non-infectious chronic inflammatory disease of the nasal mucosa with a high global prevalence. It is characterized by recurrent episodes that significantly impair patients’ quality of life. In TCM, AR is generally classified under the category of Bi Qiu (nasal discharge), and its pathogenesis is believed to be closely related to deficiency of the lung, spleen, and kidney, combined with invasion of external wind–cold pathogens. Clinically, a mixed pattern is commonly observed, involving external wind–cold invasion, disharmony of nutritive and defensive qi, lung–spleen qi deficiency, and kidney essence insufficiency.
Purely symptomatic treatment often produces marked short-term relief but fails to achieve satisfactory long-term control. Based on the therapeutic principle of “supporting healthy qi and strengthening the root while dispelling wind and散寒,” this study integrates classical herbal formulas with regionally characteristic medicinal herbs to establish a fixed compound prescription and observes its long-term clinical efficacy.
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Formula Composition and Preparation
1. Herbal Components
• Base Formulas:
Astragalus (Huang Qi) 30 g, stir-fried Atractylodes macrocephala (Chao Bai Zhu) 20 g, Saposhnikovia (Fang Feng) 6 g
(Yu Ping Feng San: tonifies qi and stabilizes the exterior)
Cinnamon twig (Gui Zhi) 12 g, White peony root (Bai Shao) 6 g, Fresh ginger (Sheng Jiang) 10 g, Honey-fried licorice (Zhi Gan Cao) 8 g, Jujube (Da Zao) 3 pieces
(Gui Zhi Tang: harmonizes the nutritive and defensive qi)
• Astringent Lung Herbs:
Mume fruit (Wu Mei) 12 g, Schisandra (Wu Wei Zi) 8 g
(astringe the lung and relieve sneezing)
• Kidney- and Essence-Tonifying Herbs:
Prepared Rehmannia (Shu Di Huang) 30 g, Polygonatum (Huang Jing) 10 g, Polygonum multiflorum (He Shou Wu) 10 g, Cornus fruit (Shan Zhu Yu) 12 g, Psoralea (Bu Gu Zhi) 12 g
(tonify the kidney and essence, strengthen the constitutional root)
• Wind-Dispelling and Orifice-Opening Herbs:
Tribulus (Bai Ji Li) 10 g, Tian Niu Li 10 g, Bai Hua Shi Mu Tou 10 g, Wu Zhao Long 10 g, Bai She Gen 10 g, Niu Ru Gen 10 g
(dispel wind, eliminate dampness, open the nasal orifices, and relieve itching)
2. Preparation and Administration
All herbs are ground into a fine powder and formed into honey pills, each weighing approximately 10 g.
Dosage: one pill per dose, twice daily, taken with warm water.
Treatment duration: one continuous 60-day course.
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Clinical Observation Results (Based on Provided Data)
• Subjects:
500 patients diagnosed with chronic wind–cold–type allergic rhinitis, based on recurrent clear nasal discharge, paroxysmal sneezing, nasal and ocular itching aggravated by wind–cold exposure, pale tongue with white coating, and related findings.
• Efficacy Criteria:
Long-term cure was defined as complete resolution of symptoms with no recurrence during one year of follow-up after discontinuation of treatment.
• Results:
Patients generally reported symptom improvement within 24 hours of initiating treatment (“as responsive as striking a drum”). After completing one 60-day course and undergoing one-year follow-up without further medication, no recurrence was observed in any of the cases, indicating both rapid onset and sustained clinical efficacy.
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Formula Analysis and Mechanistic Discussion
1. TCM Theoretical Interpretation
This formula precisely addresses the core pathomechanism of “external wind–cold invasion with lung–spleen qi deficiency and kidney essence insufficiency,” fully embodying the principle of treating both manifestation and root.
• Treating the Manifestation (Dispelling wind–cold and harmonizing nutritive and defensive qi):
Gui Zhi Tang warms and releases the exterior, harmonizes nutritive and defensive qi, and directly targets wind–cold exterior patterns, alleviating nasal congestion, clear rhinorrhea, and aversion to wind. Tribulus and other regional herbs enhance wind-dispelling and antipruritic effects. Mume fruit and Schisandra astringe lung qi, effectively suppressing frequent sneezing.
• Treating the Root (Tonifying qi, securing the exterior, strengthening spleen and kidney):
Yu Ping Feng San strengthens qi and stabilizes the exterior, enhancing resistance to external pathogens (allergens) and serving as the therapeutic core. Large doses of kidney- and essence-tonifying herbs such as prepared Rehmannia, Polygonatum, and Cornus aim to warm kidney yang and replenish kidney essence. As “the kidney governs grasping of qi,” a strong kidney supports lung qi and reduces recurrence at its root. Psoralea warms and tonifies kidney yang and has been shown in modern studies to possess anti-inflammatory and anti-allergic effects. Regional herbs such as Bai Hua Shi Mu Tou and Wu Zhao Long strengthen the spleen and resolve dampness, thereby cutting off the source of phlegm and nasal discharge.
2. Modern Pharmacological Support
• Immunomodulatory and Anti-allergic Effects:
Polysaccharides from Astragalus and Atractylodes enhance macrophage function, regulate Th1/Th2 cytokine balance, and inhibit excessive IgE production. Mume fruit and Schisandra exhibit antihistamine effects and stabilize mast cell membranes. Compounds such as psoralen from Psoralea and saponins from Tribulus demonstrate anti-inflammatory and immunosuppressive activity.
• Anti-inflammatory and Local Effects:
Volatile oils from cinnamon twig and ginger dilate mucosal blood vessels, improve microcirculation, and reduce nasal mucosal edema. Paeoniflorin from white peony exhibits significant anti-inflammatory and antispasmodic properties.
• Hormone-like and Adaptogenic Effects:
Kidney-tonifying herbs such as prepared Rehmannia, Polygonum multiflorum, and Polygonatum are rich in polysaccharides and steroid-like compounds, which may regulate the hypothalamic–pituitary–adrenal (HPA) axis, exert endogenous corticosteroid-like effects, and enhance tolerance to allergic stress.
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Scientific Basis for Dietary Restrictions
Patients were instructed to avoid dairy products, gluten-containing sweets (such as bread), and cold or raw foods (cold beverages, salads, raw fruits). This recommendation is supported by both TCM and modern medical perspectives.
• TCM Perspective:
These foods are considered cold, damp, or overly rich and cloying, which impair spleen yang and promote dampness and phlegm. As the spleen is the foundation of postnatal qi, spleen deficiency leads to damp accumulation that ascends to the nasal orifices, aggravating rhinorrhea. Avoidance helps reduce internal dampness and supports spleen and kidney function.
• Modern Medical Perspective:
Some patients with allergic rhinitis also exhibit food intolerance or hypersensitivity. Dairy products (lactose, casein) and gluten are common potential allergens that may provoke cross-reactivity or exacerbate mucosal inflammation. Cold foods can induce reflex vasoconstriction followed by rebound vasodilation of the nasal mucosa, triggering or worsening symptoms. Dietary management therefore helps reduce the overall inflammatory burden.
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Discussion and Value for Dissemination
This compound formula and its adjunctive regimen clearly align TCM pattern differentiation (wind–cold type) with the Western medical diagnosis of allergic rhinitis, simplifying clinical application and facilitating dissemination. The rapid onset of action (“within one day”) enhances patient confidence, while the absence of recurrence at one-year follow-up highlights its potential for durable resolution. Combined with explicit dietary guidance, it forms an integrated intervention encompassing both pharmacological and lifestyle modification strategies.
This protocol is suitable for standardized application in hospital TCM departments, integrative medicine clinics, community health centers, and international chain TCM clinics. Under the framework of the Belt and Road Initiative, internationalized cities such as Shenzhen and Shanghai may serve as training hubs for integrative medicine practitioners, promoting this clinically validated and effective protocol to Southeast Asia, Europe, and North America. Future multicenter, randomized, double-blind controlled trials (RCTs) are warranted to generate higher-level evidence.
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Conclusion
The compound honey-pill formula observed in this study—integrating Yu Ping Feng San, Gui Zhi Tang, kidney-tonifying and wind-dispelling herbs, together with strict dietary management—demonstrates rapid onset and sustained efficacy in the treatment of chronic wind–cold–type allergic rhinitis. Its formulation is rigorous, closely aligned with disease pathogenesis, and supported by preliminary modern pharmacological evidence, embodying the TCM principle of “treating both root and manifestation.” This protocol is readily standardized and applied, providing a promising model for integrative management of allergic rhinitis and its international dissemination.
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