01/23/2026
Sharing some tips on aromatase inhibitor associated musculoskeletal syndrome (and joint pain from other cancer therapies as well). I know it can feel like a vicious cycle when it is too painful to exercise!! Share what has worked for you as well.
Here are possible solutions and strategies that can help especially when it is too painful to exercise:
• Medication adjustments: A short break from the aromatase inhibitor or switching aromatase inhibitors (or switching to tamoxifen) might help.
• Over-the-counter pain relief: Short-term use of NSAIDs or acetaminophen is reasonable, but long-term use and opioids are generally discouraged.
• Bone-directed therapies: Bisphosphonates may modestly reduce pain in addition to their benefits for bone health and breast cancer recurrence risk.
• Other medications: Duloxetine is an antidepressant medication that can also be used for chemotherapy-induced peripheral neuropathy and has been shown to have some benefit for joint pain from AIs. Steroids may help but should be limited to short courses due to risks with chronic use.
• Supplements: Some studies show potential benefit forglucosamine-chondroitin, tart cherry and omega-3 fatty acids (benefit for omega 3 fatty acids limited to patients with obesity) may help. Vitamin D is not recommended solely for AIMSS prevention or treatment. Curcumin (the active ingredient in turmeric) may have some benefit in osteoarthritis but there is a lack of data evaluating curcumin for AIMSS.
• Site-directed therapy: Carpal tunnel release, splints, or steroid injections for trigger finger may be considered when needed.
• Complementary approaches: Acupuncture, physical therapy, occupational therapy, and massage can prove beneficial.
*starting with some very low impact movement for a short period of time can help!
Let me know what has worked for you/questions!
