Work from Home, Epigenetics, Simple Nutrition, Freedom & Young Lifestyle

03/30/2022

Good news for men.

BAZ2A is an epigenetic reader of H3K14ac and regulates prostate cancer stem cells though its association with inactive enhancers. Inactivation of BAZ2A-bromodomain impairs prostate cancer stem cells ...

02/19/2022

02/05/2022

Good update and changes at Reliv.
https://fb.watch/a_ny879EYd/

09/12/2021

https://m.facebook.com/story.php?story_fbid=10224177984653934&id=1131066088

09/09/2021

More good news about Reliv.

ArticleViewAbstractPharmacognosy Journal,2021,13,5,1269-1276.DOI:10.5530/pj.2021.13.160Published:September 2021Type:Research ArticleIn Vivo Antimammary Tumor Effects of Soybean Extract with Targeted Lunasin (ET-Lun)Numlil Khaira Rusdi, Erni Hernawati Purwaningsih, Andon Hestiantoro, Berna Elya, and....

07/22/2021

More good news about the benefits of lunasin found in Reliv.

We hereby have characterized lunasin as an immunomodulatory peptide with potential capacity to prevent immune and inflammatory-mediated disorders in the human gastrointestinal tract.

04/15/2021

Question about our newest liquid product containing lunasin and CBD.

03/21/2021

Chronic disease may not be genetic. Check this out. Our epigenetic boost comes from LunaRich by Reliv.

12/11/2020

Listen to Dr. Fred Galvez.

Researchers say if results can be validated through further studies, human clinical trials could start within two years.

07/18/2020

More good news about Reliv products containing lunasin.

The addition of an appropriate adjuvant that activates the innate immunity is essential to subsequent development of the adaptive immunity specific to…

05/13/2020

What makes lunasin a unique and potent anti-inflammatory agent

The medical establishment has not been receptive to the use of natural bioactive agents as anti-inflammatory agents because of the lack of molecular mechanisms of action. Unlike most natural bioactive agents identified to have anti-inflammatory properties, lunasin has both biochemical (signal transduction pathway) and epigenetic mechanisms of action, making it a unique and more potent anti-inflammatory agent.

1) Lunasin has an RGD (arginine-glycine-aspartic acid) cell adhesion motif that attaches specifically to the a5b3 integrin receptor, the cell membrane receptor of the LPS (lipopolysaccharide) bacterial endotoxins that can elicit a strong immune and inflammatory response in our body. The competitive binding of lunasin to the LPS-specific integrin receptor inhibits the signal transduction pathway that activates NFkappaB, the master regulator of inflammation response, and prevents the expression of pro-inflammatory genes.
References: https://pubmed.ncbi.nlm.nih.gov/?term=lunasin%20and%20inflammation

2) Lunasin has a chromo-binding motif that binds to histone H4 tail and inhibits H4-lysine 8 acetylation (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210036/). A recent publication in Science has revealed that H4-lysine 5 and H4-lysine 8 acetylation are required by BET (bromodomain and extra terminal domains) proteins to target and rapidly increase expression of pro-inflammatory genes induced by inflammatory signals (https://science.sciencemag.org/content/368/6489/387). By inhibiting H4-lysine 8 acetylation, lunasin prevents BET proteins from targeting and activating genes involved in the inflammation response, thereby reducing expression of pro-inflammatory cytokines such as TNFa (tumor necrosis factor a), IL-1 (interleukin-1) and IL-6 (interleukin-6).

03/28/2020

Boost your immunity.

The addition of an appropriate adjuvant that activates the innate immunity is essential to subsequent development of the adaptive immunity specific to…

03/18/2020

We are now in the exponential phase of the coronavirus infection in the US.

We need to flatten the curve by heeding the advise of health experts to practice social distancing and good hygiene or else our healthcare system will be overwhelmed.

At 2% mortality rate, allowing the infection rate to grow uncontrollably can lead to thousands of death.

The genetic material of this novel coronavirus is RNA (single stranded), which has a higher mutation rate than DNA (double stranded), so there is an urgent need to lower the number of infections to reduce chances of mutations that may lead to a more infectious and virulent coronavirus.

03/15/2020

We’re in the wellness industry (something everyone is talking about right now) and our products are here to support your overall wellness during this season and every day. In recent days, the world…

02/22/2020

The epigenetics of people who use exclusively use v**e pens versus ci******es has been examined for the first time. Key epigenetic modifications were identified that were shared between v**ers and smokers that are a hallmark of lung cancer. Va**ng which has been generally marketed as a less dangerou...

12/14/2019

Nutritional Epigenetics – Ushering a new era of nutrition science

The attached image is the concluding slide of my presentation at an International Symposium on Nutritional Genomics in 2007.

Using the lunasin peptide as a model, I advocated for a shift in nutritional genomics research to take into consideration the effects of low potency food bioactive agents on the epigenome as mechanisms to elucidate their wide-ranging influence in promoting health and preventing age-related chronic diseases.

It has taken more than a decade for epigenetic science to catch up, but it is now undeniable that nutritional epigenetics represents a new era of scientific research in understanding the profound effects of diet and nutrition on health, wellness and longevity.

11/21/2019

Statins are the most popular therapeutic drugs to lower plasma low density lipoprotein cholesterol (LDL-C) synthesis by competitively inhibiting hydroxyl-3-methyl-glutaryl-CoA (HMG-CoA) reductase and up-regulating the hepatic low density lipoprotein receptor (LDLR). However, the concomitant up-regul...