Annals of Internal Medicine: Clinical Cases

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Annals of Internal Medicine: Clinical Cases

A partnership between the American College of Physicians and the American Heart Association, AIMCC i

$Online now: Elevated Activated Partial Thromboplastin Time in the Setting of Prophylactic Unfractionated Subcutaneous He...$

11/13/2025

Online now: Elevated Activated Partial Thromboplastin Time in the Setting of Prophylactic Unfractionated Subcutaneous Heparin Administration

Read the full text for free: https://f.mtr.cool/hpxxnkfmkk

11/12/2025

Researchers present a case of ocular Lyme borreliosis, a rare complication of late-stage Lyme disease, that was successfully treated with a combination of high-dose steroids in conjunction with IV antibiotics. https://f.mtr.cool/wtdfdvkhza

11/11/2025

The case of an 84-year-old woman who took hydroxychloroquine (HCQ) for several years for cutaneous lupus and later developed HCQ-induced cardiomyopathy highlights a rare side effect of prolonged HCQ use. https://f.mtr.cool/zxrhjidwtu

11/10/2025

A new case teaches two important lessons. First, it shows a very large pericardial effusion with clear echo findings and the unusual symptom of dysphagia from a common disease. Second, it highlights the challenges of diagnosing patients with developmental delay, where communication can be difficult. Read the full text and see the video: https://f.mtr.cool/tankcozngy

11/07/2025

A case report describes a patient with a paradoxical increase in low-density lipoprotein cholesterol (LDL-C) following proprotein convertase subtilisin/kexin type 9 inhibitor (PCSK9i) therapy with evolocumab. This case highlights an unusual response to PCSK9i use that warrants further investigation. https://f.mtr.cool/wfmvsvqdsp

11/06/2025

NEW: A case of thrombotic cutaneous gangrene in a patient with ulcerative colitis (UC) reiterates a rare but significant complication of UC. The authors say that patients with UC presenting with rapidly progressing skin lesions should be evaluated quickly with a hypercoagulation panel and skin biopsy. https://f.mtr.cool/jrlhfmjyxb

11/05/2025

A 20-year-old woman presented to the ER a few times with severe abdominal pain, nausea, and vomiting coinciding with her menstrual period. She was found to have developed posterior reversible encephalopathy syndrome (PRES) and was later diagnosed with acute intermittent porphyria (AIP), a rare heme synthesis disorder that is often misdiagnosed.

This case underscores the importance of considering AIP as a potential diagnosis in patients with recurrent, unexplained abdominal pain. https://f.mtr.cool/lafqvzaxfg

11/04/2025

Online now: Authors present an atypical case of Whipple disease, rare infection primarily reported in White men, with mesenteric lymphadenopathy and an exudative pleural effusion. The case highlights how Whipple disease should be considered in patients with unexplained weight loss, abdominal pain, and mesenteric lymphadenopathy after malignancy and common infections have been excluded. https://www.acpjournals.org/doi/10.7326/aimcc.2025.0337?utm_source=facebook&utm_medium=social&utm_campaign=aimcc&utm_term=cr&utm_content=scard

11/03/2025

A cerebrospinal fluid (CSF) analysis was used to diagnose a 33-year-old man with posterior reversible encephalopathy syndrome (PRES) after clonidine withdrawal. The case underscores the diagnostic value of CSF analysis in rapidly evolving neurologic conditions when MRI is delayed or unavailable and highlights the risk for PRES as a complication of clonidine withdrawal. https://www.acpjournals.org/doi/10.7326/aimcc.2025.0168?utm_source=facebook&utm_medium=social&utm_campaign=aimcc&utm_term=cr&utm_content=scard

10/31/2025

Online now: A 40-year-old man with metastatic castration-resistant prostate adenocarcinoma presented with worsening left lower extremity edema. He was diagnosed with ectopic adrenocorticotropic hormone, a rare condition seen in 10% of all Cushing syndrome cases. https://www.acpjournals.org/doi/10.7326/aimcc.2025.0356?utm_source=facebook&utm_medium=social&utm_campaign=aimcc&utm_term=cr&utm_content=scard

10/30/2025

A case report details a 15-year-old boy with obesity and mild asthma presented to the ED with progressive respiratory distress despite treatment for suspected pneumonia. Testing revealed he had antisynthetase polymyositis, and 15 months later, he was found to have Klinefelter syndrome, the most common s*x chromosomal disorder. The case highlights the s*x bias of autoimmune disease. https://www.acpjournals.org/doi/10.7326/aimcc.2025.0583?utm_source=facebook&utm_medium=social&utm_campaign=aimcc&utm_term=cr&utm_content=scard

10/29/2025

Prolonged and progressive lower back pain in a 50-year-old man was found to be caused by a rare giant lumbar schwannoma, a benign nerve sheath tumor. Authors say lumbar schwannoma must be included among differential diagnoses for radicular low back pain. https://www.acpjournals.org/doi/10.7326/aimcc.2025.0353?utm_source=facebook&utm_medium=social&utm_campaign=aimcc&utm_term=cr&utm_content=scard

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