The Children's Hospital of Philadelphia Research Institute

The Children's Hospital of Philadelphia Research Institute CHOP Research advances the health of children by turning scientific discovery into medical innovation
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Applications are now open for the Summer 2026 Advancing Representation in Research Administration (ARRA) Program at Chil...
12/04/2025

Applications are now open for the Summer 2026 Advancing Representation in Research Administration (ARRA) Program at Children's Hospital of Philadelphia Research Institute!

Undergraduate students from a wide variety of majors are invited to apply to gain practical training and a glimpse into what a career in research administration could look like.

Applications and references are due Jan. 25, 2026! Visit our website to learn about the program and register for our upcoming virtual information session. http://ms.spr.ly/6187td2SN

The inaugural RNA Day at CHOP alongside the University of Pennsylvania’s Institute of RNA Innovation was a success 🧬! CH...
12/03/2025

The inaugural RNA Day at CHOP alongside the University of Pennsylvania’s Institute of RNA Innovation was a success 🧬! CHOP and Penn researchers shared their RNA research findings, from biology to therapeutics, and celebrated the advances made possible by the ever-growing collaboration between the two institutions. In this new Cornerstone Q&A, Dr. Stefano Rivella, leader of the Rivella Lab at CHOP and RNA Gene Therapeutics at the Penn Institute for RNA Innovation, explains how RNA Day came to fruition and what comes next.

http://ms.spr.ly/6180tjtJ6

Researchers in Children's Hospital of Philadelphia’s Craniofacial Frontier Program are building an evidence base for the...
12/01/2025

Researchers in Children's Hospital of Philadelphia’s Craniofacial Frontier Program are building an evidence base for the most effective treatment approaches to craniosynostosis, a rare congenital condition in which skull bones fuse too early, leading to potential lifelong challenges in appearance, brain function, and vision.

Currently, there are no prospective studies to inform craniosynostosis treatment, so procedures, timing, and approaches vary widely across centers in the United States and around the world. Now, Dr. Eric Liao and his team will lead the first comprehensive, multi-site effort to study how craniosynostosis problems evolve over time and compare outcomes from the three most common surgical methods.

“It will establish the best practices for our field, and it will save lives,” Dr. Liao said. Read more on Cornerstone: http://ms.spr.ly/6182tXiUg

Congratulations to Dr. Gerd Blobel, a Children's Hospital of Philadelphia investigator and Frank E. Weise III Chair in H...
11/28/2025

Congratulations to Dr. Gerd Blobel, a Children's Hospital of Philadelphia investigator and Frank E. Weise III Chair in Hematology, for his election to the prestigious National Academy of Medicine! Dr. Blobel’s storied research career has advanced what we know about the factors driving spatial organization of the genome in the cell’s nucleus, the mechanisms of globin gene regulation, and how epigenetic information is passed through the cell division cycle.

“My election to the National Academy of Medicine reflects the fantastic team members and collaborators I’ve worked with over the years,” Dr. Blobel said.

Read more about how Dr. Blobel’s work has advanced children’s health on Cornerstone: http://ms.spr.ly/6189tXiwd

Children's Hospital of Philadelphia and University of Pennsylvania researchers are identifying and describing the viruse...
11/26/2025

Children's Hospital of Philadelphia and University of Pennsylvania researchers are identifying and describing the viruses that live among us, by participating in a national, pioneering initiative called the Human Virome Program. The CHOP-Penn team will sequence samples from hundreds of pediatric and adult patients to learn more about the role viruses play as potential partners in our bodies. Learn more in a new Cornerstone story: http://ms.spr.ly/6188tX9AA

When you support research at Children's Hospital of Philadelphia, you become part of every life that research touches, w...
11/26/2025

When you support research at Children's Hospital of Philadelphia, you become part of every life that research touches, whether it's a child receiving a revolutionary gene therapy, a family finally getting a rare disease diagnosis, or an adolescent enrolling in a life-changing mental health intervention. This holiday season, join us in shaping the future of children's health by making an investment in an area of high-impact science that matters most to you.

Visit our Research Giving Page to explore unique ways to donate, and learn how your generosity can bring hope and healing to families around the world: http://ms.spr.ly/6182tXR8y

New research findings from Children's Hospital of Philadelphia researchers suggests that mitochondrial dysfunction in th...
11/26/2025

New research findings from Children's Hospital of Philadelphia researchers suggests that mitochondrial dysfunction in the blood-brain barrier may underlie neuropsychiatric symptoms in some patients with 22q11.2 deletion syndrome. In our latest Snapshot Science, learn how researchers used a clinically approved, lipid-lowering drug in a preclinical model to treat the mitochondrial dysfunction. http://ms.spr.ly/6180tXR6o

11/21/2025

At last Wednesday’s annual Discovery Day, two high school students Brooklyn Jackson of Penn Treaty () and Mahjeer Marshall of Mastery Charter Hardy Williams High () shared their experiences at the day-long event ⭐ Since 2016, Discovery Day has encouraged local high school students from all backgrounds to explore careers in and apply for our summer research internship programs. Thank you to Michelle Marshall and our Office of Academic Training and Research Programs for leading this unique and exciting event! Read more about Discovery Day at the link in our bio 🔗

11/19/2025

Inside the newest addition to our Children's Hospital of Philadelphia research campus, the Morgan Center for Research and Innovation, you will find the IDEA Lab -- a place where our researchers can work with on-site engineers to create the prototypes that will power their research.

Learn more about the Innovate, Design, Engineer, and Accelerate (IDEA) Lab in a brand-new episode of our Bench to Bedside podcast featuring special guest Dr. Elizabeth Silvestro and podcast host Dr. Susan Furth. Listen to the full episode on Spotify now: http://ms.spr.ly/6183trcNU

Today is   💚 We are proud to highlight the remarkable work of our Center for Injury Research and Prevention (CIRP) at Ch...
11/18/2025

Today is 💚 We are proud to highlight the remarkable work of our Center for Injury Research and Prevention (CIRP) at Children's Hospital of Philadelphia, who investigate safety measures to save lives all year round. From preventing concussions to driving safety and so much more, learn more about CIRP: http://ms.spr.ly/6183trJj7

Center for Injury Research and Prevention at CHOP

November marks  . Members of Children's Hospital of Philadelphia's newly established Indigenous Health Unit (IHU) visite...
11/14/2025

November marks . Members of Children's Hospital of Philadelphia's newly established Indigenous Health Unit (IHU) visited the historic site of the Carlisle Indian Industrial School, in late October. Dr. Lou Bell, Professor of Pediatrics and The Patrick S. Pasquariello Jr. Endowed Chair in Pediatric Medicine at CHOP, joined the group and shared these words about the outing and its importance for :

“Founded in 1879, Carlisle was the first federal off-reservation boarding school for Native American children. Its stated purpose was to “assimilate” Indigenous youth, through the erasure of their language, culture, and identity. A total of 7,800 students attended the school from 1879 to 1918. Although the school closed over 100 years ago, the impact on the Native peoples’ descendants reverberates strongly today. Our group felt the impact while reading and listening to the stories of the Peoples during our tour.

For CHOP’s IHU, the visit was more than a reflection on history — it was a commitment to doing better in the present. Standing on those grounds reminded our team that true health equity must include respect for history, culture, and self-determination. The IHU’s mission is to advance research and care that includes, supports, and empowers American Indian and Alaska Native communities, not by studying them as subjects, but by partnering with them as equal leaders and knowledge holders.

The visit to Carlisle reaffirmed CHOP’s dedication to building relationships rooted in trust and reciprocity. As we move forward, the IHU will continue to collaborate with tribal nations, Native scholars, and community organizations to ensure that our research, education, and clinical programs honor Indigenous voices and strengthen community wellness.

Our time at Carlisle was a powerful reminder: Healing begins with truth, and progress grows from partnership."

Learn more about the IHU at CHOP: http://ms.spr.ly/6189tOFH9

Join us in congratulating two leaders of our Minds Matter Concussion Program, Co-Director Dr. Kristy Arbogast and Co-Cli...
11/10/2025

Join us in congratulating two leaders of our Minds Matter Concussion Program, Co-Director Dr. Kristy Arbogast and Co-Clinical Director Dr. Matthew Grady, for their induction as Fellows of the College of Physicians!

Drs. Arbogast and Grady are pictured here with Minds Matter Co-Director and Fellow Dr. Christina Master and join a prestigious list of medical professionals in the Philadelphia-based organization seeking to improve medical education, scientific medicine, and public health. Learn more about Minds Matter, a leading concussion care center with a robust translational research program: http://ms.spr.ly/6181tzUsX

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