The Children's Hospital of Philadelphia Research Institute

The Children's Hospital of Philadelphia Research Institute CHOP Research advances the health of children by turning scientific discovery into medical innovation
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02/09/2026

In this short video, Children's Hospital of Philadelphia psychologist Dr. Benjamin Yerys talks about how the Armellino Center of Excellence for Williams Syndrome (WS), a collaboration between CHOP and the University of Pennsylvania's Perelman School of Medicine that opened its new state-of-the-art facility in June 2025, supports his work improving the transition to adulthood for individuals with WS.

WS is a genetic neurodevelopmental disorder that affects approximately 1 in every 7,500 individuals. Learn more in our 2025 Research Annual Report: http://ms.spr.ly/6188QP3EO

02/03/2026

Join Dr. Stephan Kadauke, Associate Director of Children's Hospital of Philadelphia's Cell Based Therapy Laboratory, in this brief video as he explains how working together with Brazil is the start of a bigger global initiative to bring cell and gene therapy at an affordable price point to low-and-middle-income countries. Read the full story in our 2025 Research Annual Report: http://ms.spr.ly/6186QKTYk

Meet Dr. Camila Polanco, an investigator in the Supporting Promising Academic Researchers (SPAR) fellowship at CHOP and ...
02/02/2026

Meet Dr. Camila Polanco, an investigator in the Supporting Promising Academic Researchers (SPAR) fellowship at CHOP and the University of Pennsylvania. Under the mentorship of Dr. Tracy Waasdorp, Director of Research for School-Based Bullying and Social Emotional Learning at CHOP, Dr. Polanco wants to bring programs to academic spaces that help children cultivate a sense of belonging among peers. Learn more about Dr. Polanco’s work and how the SPAR program supports researchers and educators, in a new Q&A: http://ms.spr.ly/6189QKRRD

CHOP investigators studied how rare inherited genetic variants contribute to the development of brain and spinal cord tu...
01/30/2026

CHOP investigators studied how rare inherited genetic variants contribute to the development of brain and spinal cord tumors. The findings, summarized in a new Snapshot Science blog, reveal insights into how hereditary genetic changes influence cancer risk and outcomes. Learn more about our research conducted with researchers at Children’s National Hospital: http://ms.spr.ly/6189QyB6b

This week in our research news roundup at Children's Hospital of Philadelphia, celebrate early-career scientists honored...
01/27/2026

This week in our research news roundup at Children's Hospital of Philadelphia, celebrate early-career scientists honored by a historic medical society, learn about research to help prevent newborn sepsis, and read about an evaluation of a health partnership in Botswana. Our latest In the News is up on the Cornerstone blog now: http://ms.spr.ly/6182Q1LhM

01/27/2026

For genomics researchers, identifying disease-causing variants can be like following "footprints" to learn more about the mechanisms underlying disease. Watch Dr. Struan Grant, Director of the Center for Spatial and Functional Genomics at Children's Hospital of Philadelphia, talk about how his team successfully utilized an algorithm to identify potential mutations in noncoding regions of our DNA that could increase disease risk. As these regions make up more than 98% of our DNA, the findings lay the foundation for clinicians to detect disease-associated variants in a range of common diseases. To read the full story, visit our 2025 Research Annual Report online: http://ms.spr.ly/6181Q1q8Z

01/21/2026

Watch Dr. Beverly Davidson, Director of the Raymond G. Perelman Center for Cellular and Molecular Therapeutics at Children's Hospital of Philadelphia, talk about her team's identification of two novel adeno-associated virus (AAV) capsid variants that could improve the cost, dosage, and precision of gene therapy to the brain. "Imagine looking at the night sky in New York City, where you'll see only the moon and a handful of stars," Dr. Davidson said. "That is the current state of gene therapy. What we've created here is like looking at the night sky over the Sahara Desert."

To learn more about our development of unique, leading-edge technologies at CHOP, check out our 2025 Annual Report: http://ms.spr.ly/6189QBeYt

01/12/2026

In this video, Dr. Rebecca Ahrens-Nicklas, Assistant Professor of Pediatrics at Children's Hospital of Philadelphia, talks about one of our biggest breakthroughs of 2025: the treatment of Baby KJ Muldoon with the first-ever personalized gene-editing drug. You can read about Baby KJ's full story, beginning with his diagnosis at CHOP via the Baby Eagle Initiative, in our 2025 Research Annual Report: http://ms.spr.ly/6188tfiWe

🏥 2025 was a big year for breakthroughs that brought years of scientific research to the bedside. In the gallery below, ...
01/02/2026

🏥 2025 was a big year for breakthroughs that brought years of scientific research to the bedside. In the gallery below, read about some of these discoveries from our investigators at Children's Hospital of Philadelphia Research Institute, including the first-ever personalized gene therapy for a rare disease, a novel vaccine to prevent and treat the bacterial infection Clostridioides difficile, and more. You also can read each full story in our 2025 Research Annual Report, now live! http://ms.spr.ly/6181tINlx

Our annual round-up of the most popular stories of #2025 is here! We tallied up the Cornerstone blog posts that receive...
12/31/2025

Our annual round-up of the most popular stories of #2025 is here! We tallied up the Cornerstone blog posts that received the most engagements on our social media platforms to see what research stories resonated the most with you, our community, in 2025. Check out the full list now: http://ms.spr.ly/6184taRNk

12/30/2025

Our 2025 Research Annual Report is live! Click the link in our bio to dive into this celebration of our advances and accomplishments, from cultivating a world-class academic medical research community to developing transformative technologies and treatments, and so much more. From our community to yours, CHOP Research Institute wishes you happy holidays ⭐

12/29/2025

2025 was a transformative year at Children's Hospital of Philadelphia Research Institute!

Our scientists shared their thought leadership through global collaborations and personalized approaches to pediatric care.

We expanded our physical footprint with the launch of new institutes and our scientific imprint by establishing innovative research programs and centers of emphasis.

Several groundbreaking therapies—like a first-in-kind gene-editing treatment for a newborn and expanded access to CAR-T therapy—demonstrated our continued leadership in advancing rare disease care.

And our researchers developed novel scientific tools and techniques, including a wearable neuroimaging device, deep learning genomic models, and next-generation gene therapy delivery platforms.

We invite you to watch this video with Executive Vice President and Chief Scientific Officer Dr. Susan Furth, or take a moment to read our 2025 Research Annual Report, now available to view online: http://ms.spr.ly/6181taRvv

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